ID   D8G250_9CYAN            Unreviewed;       620 AA.
AC   D8G250;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   SubName: Full=2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase {ECO:0000313|EMBL:CBN56690.1};
DE            EC=2.7.7.60 {ECO:0000313|EMBL:CBN56690.1};
GN   Name=ispD {ECO:0000313|EMBL:CBN56690.1};
GN   ORFNames=OSCI_3130017 {ECO:0000313|EMBL:CBN56690.1};
OS   Kamptonema sp. PCC 6506.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC   Oscillatoriales; Microcoleaceae; Kamptonema.
OX   NCBI_TaxID=272129 {ECO:0000313|EMBL:CBN56690.1, ECO:0000313|Proteomes:UP000004532};
RN   [1] {ECO:0000313|Proteomes:UP000004532}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6506 {ECO:0000313|Proteomes:UP000004532};
RX   PubMed=20675499; DOI=10.1128/JB.00704-10;
RA   Mejean A., Mazmouz R., Mann S., Calteau A., Medigue C., Ploux O.;
RT   "The genome sequence of the cyanobacterium Oscillatoria sp. PCC 6506
RT   reveals several gene clusters responsible for the biosynthesis of toxins
RT   and secondary metabolites.";
RL   J. Bacteriol. 192:5264-5265(2010).
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DR   EMBL; CACA01000278; CBN56690.1; -; Genomic_DNA.
DR   RefSeq; WP_007355901.1; NZ_CACA01000278.1.
DR   AlphaFoldDB; D8G250; -.
DR   OrthoDB; 475586at2; -.
DR   Proteomes; UP000004532; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050518; F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR010297; DUF900_hydrolase.
DR   Pfam; PF05990; DUF900; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotidyltransferase {ECO:0000313|EMBL:CBN56690.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004532};
KW   Transferase {ECO:0000313|EMBL:CBN56690.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        223..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        276..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   620 AA;  71481 MW;  9E1DA9F063753C8C CRC64;
     MDDNTWKNDC NWLESIIRNS APFSDGWTKA RIVQLAYPDP SGTASPTTEE IVTRLRSLCD
     LKQYPMFAEK VNVDYVINTL NRWHNRQFTQ AFSRNFEIYA DCEHPNIFLV TSTASTSLNI
     DRELPPKRFR PLFNVDELAQ IVLSSGCERL TMRIHGYATP GSIFYNNFIN EAESLTLKDP
     IKNIATLEEN HFYIGYHWPS EKPLVSPGLW ADYRYNWGII LKFLIVLGVL TFISGSLLYF
     LLKLLVVPLL LSFGYFPELA NFWQWLKFRE TAELAVQWHW IIVTVFMLSL LVVQMMRIIV
     YQRDRYRAIH YGAPDFSEFF WRLDRALGID ENQSVKAKFS NRSGKVEAES EDKKEAKAAK
     SNSRIAVNLM GHSLGALVVV NSLRILSDRF GKDDIDVDDK REIGDYLILD KLIMSAPDIP
     LEFLREGRNN YVRSAILRCQ KIYLFSSDRD IVLRYLSTLA NWWVEPSLEM SGLRLGNIYL
     KEVNEGSKPV NKSEDTTKSY APYIRIMVRS QLAANPTSAY ELFEKFNYID CSEMRGVNSV
     KLPLNKFTSL AIDLINIVSF LFGKIDAHGG YFWTETPSFA VVKFLLTNQH ISEEEMEAGI
     NSLIDNSIRF WPSQPLLCKK
//