ID D8GNX4_CLOLD Unreviewed; 267 AA.
AC D8GNX4;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Methionine synthase {ECO:0000313|EMBL:ADK13820.1};
DE EC=2.1.1.13 {ECO:0000313|EMBL:ADK13820.1};
GN Name=metH2 {ECO:0000313|EMBL:ADK13820.1};
GN Synonyms=metH3 {ECO:0000313|EMBL:ADK13825.1};
GN OrderedLocusNames=CLJU_c07500 {ECO:0000313|EMBL:ADK13820.1},
GN CLJU_c07550 {ECO:0000313|EMBL:ADK13825.1};
OS Clostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=748727 {ECO:0000313|EMBL:ADK13820.1, ECO:0000313|Proteomes:UP000001656};
RN [1] {ECO:0000313|EMBL:ADK13820.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 13528 {ECO:0000313|EMBL:ADK13820.1};
RA Koepke M., Hujer S., Held C., Wiezer A., Liesegang H., Ehrenreich A.,
RA Gottschalk G., Duerre P.;
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADK13820.1, ECO:0000313|Proteomes:UP000001656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 55383 / DSM 13528 / PETC
RC {ECO:0000313|Proteomes:UP000001656}, and DSM 13528
RC {ECO:0000313|EMBL:ADK13820.1};
RX PubMed=20616070; DOI=10.1073/pnas.1004716107;
RA Kopke M., Held C., Hujer S., Liesegang H., Wiezer A., Wollherr A.,
RA Ehrenreich A., Liebl W., Gottschalk G., Durre P.;
RT "Clostridium ljungdahlii represents a microbial production platform based
RT on syngas.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:13087-13092(2010).
CC -!- SIMILARITY: Belongs to the vitamin-B12 dependent methionine synthase
CC family. {ECO:0000256|ARBA:ARBA00010398}.
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DR EMBL; CP001666; ADK13820.1; -; Genomic_DNA.
DR EMBL; CP001666; ADK13825.1; -; Genomic_DNA.
DR RefSeq; WP_013237420.1; NZ_LITS01000041.1.
DR AlphaFoldDB; D8GNX4; -.
DR STRING; 748727.CLJU_c07500; -.
DR KEGG; clj:CLJU_c07500; -.
DR KEGG; clj:CLJU_c07550; -.
DR PATRIC; fig|748727.19.peg.1451; -.
DR eggNOG; COG1410; Bacteria.
DR HOGENOM; CLU_070996_0_0_9; -.
DR OrthoDB; 358252at2; -.
DR Proteomes; UP000001656; Chromosome.
DR GO; GO:0008705; F:methionine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0042558; P:pteridine-containing compound metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.20; Dihydropteroate synthase-like; 1.
DR InterPro; IPR011005; Dihydropteroate_synth-like_sf.
DR InterPro; IPR000489; Pterin-binding_dom.
DR PANTHER; PTHR45833; METHIONINE SYNTHASE; 1.
DR Pfam; PF00809; Pterin_bind; 1.
DR SUPFAM; SSF51717; Dihydropteroate synthetase-like; 1.
DR PROSITE; PS50972; PTERIN_BINDING; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ADK13820.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ADK13820.1}.
FT DOMAIN 1..256
FT /note="Pterin-binding"
FT /evidence="ECO:0000259|PROSITE:PS50972"
SQ SEQUENCE 267 AA; 29473 MW; 366668DCAEA4ABB3 CRC64;
MIIIGEKING AIPSTGKAIA AKDSEFIRNL AIKQTEAGAD FIDVCASVDD DIELETMKWL
IDIVQDATDV PIAVDSPNPH TCVEAMKYCK KPGLFNSVSM EGDKIDVAFP AIADTKWECV
ALLNSDKGIP KTAKDRLDVF AELMAKVKEY NIDPSRMHID PLIEMLCTSE EGINMVTEVM
KKIKELYPTI HVVGAVSNIS FNIPARKIVN QAFAVLAMNA GMDSFILDPL NQDLIGMLFA
TEALLGEDEY CMEYIRAYRE GIFGKKK
//
