ID   D8GSY2_CLOLD            Unreviewed;       826 AA.
AC   D8GSY2;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 72.
DE   SubName: Full=Putative transport/signal transduction system protein {ECO:0000313|EMBL:ADK14552.1};
GN   OrderedLocusNames=CLJU_c14840 {ECO:0000313|EMBL:ADK14552.1};
OS   Clostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=748727 {ECO:0000313|EMBL:ADK14552.1, ECO:0000313|Proteomes:UP000001656};
RN   [1] {ECO:0000313|EMBL:ADK14552.1, ECO:0000313|Proteomes:UP000001656}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 55383 / DSM 13528 / PETC
RC   {ECO:0000313|Proteomes:UP000001656};
RX   PubMed=20616070; DOI=10.1073/pnas.1004716107;
RA   Kopke M., Held C., Hujer S., Liesegang H., Wiezer A., Wollherr A.,
RA   Ehrenreich A., Liebl W., Gottschalk G., Durre P.;
RT   "Clostridium ljungdahlii represents a microbial production platform based
RT   on syngas.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:13087-13092(2010).
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 3 family.
CC       {ECO:0000256|ARBA:ARBA00010333}.
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DR   EMBL; CP001666; ADK14552.1; -; Genomic_DNA.
DR   RefSeq; WP_013238149.1; NZ_LITS01000006.1.
DR   AlphaFoldDB; D8GSY2; -.
DR   STRING; 748727.CLJU_c14840; -.
DR   KEGG; clj:CLJU_c14840; -.
DR   PATRIC; fig|748727.19.peg.2940; -.
DR   eggNOG; COG0834; Bacteria.
DR   eggNOG; COG3437; Bacteria.
DR   HOGENOM; CLU_000445_92_5_9; -.
DR   OrthoDB; 9804747at2; -.
DR   Proteomes; UP000001656; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd13704; PBP2_HisK; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013656; PAS_4.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR018313; SBP_3_CS.
DR   InterPro; IPR001638; Solute-binding_3/MltF_N.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR43155:SF2; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108; 1.
DR   PANTHER; PTHR43155; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108-RELATED; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF13487; HD_5; 1.
DR   Pfam; PF08448; PAS_4; 1.
DR   Pfam; PF00497; SBP_bac_3; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00062; PBPb; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS51832; HD_GYP; 1.
DR   PROSITE; PS01039; SBP_BACTERIAL_3; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          521..656
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          642..826
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
SQ   SEQUENCE   826 AA;  93842 MW;  A122155B49345063 CRC64;
     MIEIKHKVFI IVFIAIVTCL LGNNFGKAVF ADNKESVNSN KETIYKVLGN DEKKADRTII
     IGDDKDYPPY SFIDQNGNPT GFDVELAKAA AEAMGFKVKI KLSVWSEAMD ELENGKIDVI
     AGMFYSKDRE KFYSFTTKTA ITGADVFTRK GESIKNINQL RGKTVVVESD EISGEYLKKQ
     NLGINFVKVH SSEEALKLIS MNKYDYAVVS TIIGHYFMKK DKISNIKGNG LVINPDDYCI
     AVKKGNEDLL FALNGGLQIL KATGKYDEIY NKWLGVYEEK TFYQTVIEYR SLIMASVASI
     LLLLLWNRTL KKRVVVRTKE LLEANDALNK SKQELLVSNE EIEASYNELA AIEEELRSQY
     YRLMKSEENL KKSEERNRAI VTAIPDIIFV VDGNAVFKDC QIKDASVLIM PENEFIGKTL
     WNVLPSKIAE TGFEKIKAAL KNNSLESFQY EIDTPVGKKY YELRIVKCRE NEVIVISRDI
     TDERKNQKKI EFLSYNDQLT GLYNRRFFEE EIERLNSKEN LPLTIVMADV NGLKLINDSF
     GHAAGDELLK KVSAVMLNVC SDKGIISRIG GDEFVILLPK TNELEAGKIL KRISELASKE
     KVESINLSIS FGFDTKHYDD ENVFEVLKKA EDFMYKKKLF ESPSMRGKTI GAIINTLHEK
     NKREEQHSHR VSEYCNLLGK AMNLPEGEIQ ELKTVGFLHD IGKVAIDENI LNKPGKLIDE
     EWEKIKRHPE IGYRILSSVN DMAEMSEYVL AHHERWDGKG YPKGLKGEEI PLKSRIIAIA
     DAFDAMTSER AYRSALSKEI AVEELIKNAG IQFDPELVKI FVEKVV
//