ID D8IB29_BRAP9 Unreviewed; 448 AA.
AC D8IB29;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Peptidase U62, modulator of DNA gyrase {ECO:0000313|EMBL:ADK30352.1};
GN OrderedLocusNames=BP951000_0347 {ECO:0000313|EMBL:ADK30352.1};
OS Brachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000).
OC Bacteria; Spirochaetota; Spirochaetia; Brachyspirales; Brachyspiraceae;
OC Brachyspira.
OX NCBI_TaxID=759914 {ECO:0000313|EMBL:ADK30352.1, ECO:0000313|Proteomes:UP000000332};
RN [1] {ECO:0000313|EMBL:ADK30352.1, ECO:0000313|Proteomes:UP000000332}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1826 / 95/1000 {ECO:0000313|Proteomes:UP000000332};
RX PubMed=20625514; DOI=10.1371/journal.pone.0011455;
RA Wanchanthuek P., Bellgard M.I., La T., Ryan K., Moolhuijzen P., Chapman B.,
RA Black M., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.;
RT "The complete genome sequence of the pathogenic intestinal spirochete
RT Brachyspira pilosicoli and comparison with other Brachyspira genomes.";
RL PLoS ONE 5:E11455-E11455(2010).
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
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DR EMBL; CP002025; ADK30352.1; -; Genomic_DNA.
DR RefSeq; WP_013243307.1; NC_014330.1.
DR AlphaFoldDB; D8IB29; -.
DR STRING; 759914.BP951000_0347; -.
DR GeneID; 56438926; -.
DR KEGG; bpo:BP951000_0347; -.
DR eggNOG; COG0312; Bacteria.
DR HOGENOM; CLU_026425_4_0_12; -.
DR InParanoid; D8IB29; -.
DR Proteomes; UP000000332; Chromosome.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR047657; PmbA.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR43421; METALLOPROTEASE PMBA; 1.
DR PANTHER; PTHR43421:SF1; METALLOPROTEASE PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000332}.
FT DOMAIN 25..88
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 117..220
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 228..447
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 448 AA; 50137 MW; 65773D45DB166B7F CRC64;
MERENKIKEI FNIVKNKLDN DYKIEIYMSN SGEEEFTVRE RDLDKYTFAE SGGIGLRLIK
NGQVGVSFTE KIDFNDENIN NLINNAKNSL KYAASEPEFN TLIEESEEKA YNLINKDITN
LTNDELKKIS LSIEDKLYSL DKRIVNVPSC GLARYDFSKH IINSNGICKE EKKNSISYYA
EVIAKDSNAV KTFFDVYSSK DTKFDVDSFC KNIVDNVVSK LEAKEIKSGK YKTVFTSKAM
RTMLGAYLSL FSSEAVQKQL SLLQGKLNKK IASEIINIKD IPMFDNGLAN TNFDGEGSAT
KDLNIITNGV LNSYLYNNYT ARKEKRKTTS HASRGFKTSI GISCHNLILE NGINTQEELI
SQIKDGILVN SLTGTHAGVN SISGDFSLQA EGIKIENGKL SHTANPFIVS GNILDFLNNI
EMLANDTDYH HSSIYTPSAL IKELSFSS
//
