ID D8IFL8_BRAP9 Unreviewed; 326 AA.
AC D8IFL8;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Cobalamin biosynthesis protein, CobD {ECO:0000313|EMBL:ADK31941.1};
GN Name=cobD {ECO:0000313|EMBL:ADK31941.1};
GN OrderedLocusNames=BP951000_1963 {ECO:0000313|EMBL:ADK31941.1};
OS Brachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000).
OC Bacteria; Spirochaetota; Spirochaetia; Brachyspirales; Brachyspiraceae;
OC Brachyspira.
OX NCBI_TaxID=759914 {ECO:0000313|EMBL:ADK31941.1, ECO:0000313|Proteomes:UP000000332};
RN [1] {ECO:0000313|EMBL:ADK31941.1, ECO:0000313|Proteomes:UP000000332}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1826 / 95/1000 {ECO:0000313|Proteomes:UP000000332};
RX PubMed=20625514; DOI=10.1371/journal.pone.0011455;
RA Wanchanthuek P., Bellgard M.I., La T., Ryan K., Moolhuijzen P., Chapman B.,
RA Black M., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.;
RT "The complete genome sequence of the pathogenic intestinal spirochete
RT Brachyspira pilosicoli and comparison with other Brachyspira genomes.";
RL PLoS ONE 5:E11455-E11455(2010).
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CobD/CbiB family.
CC {ECO:0000256|ARBA:ARBA00006263}.
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DR EMBL; CP002025; ADK31941.1; -; Genomic_DNA.
DR RefSeq; WP_013244890.1; NC_014330.1.
DR AlphaFoldDB; D8IFL8; -.
DR STRING; 759914.BP951000_1963; -.
DR GeneID; 56440519; -.
DR KEGG; bpo:BP951000_1963; -.
DR eggNOG; COG1270; Bacteria.
DR HOGENOM; CLU_854363_0_0_12; -.
DR InParanoid; D8IFL8; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000000332; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048472; F:threonine-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR004485; Cobalamin_biosynth_CobD/CbiB.
DR PANTHER; PTHR34308; COBALAMIN BIOSYNTHESIS PROTEIN CBIB; 1.
DR PANTHER; PTHR34308:SF1; COBALAMIN BIOSYNTHESIS PROTEIN CBIB; 1.
DR Pfam; PF03186; CobD_Cbib; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000332};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 49..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 326 AA; 37365 MW; 5306EB0D8CD0B1B3 CRC64;
MQTLLILPIS FLLNIFVYRF KIDIFQYIRI PIEKLQYLLK DKVYKNNEIL ELILGIVISL
IILSISFIAP YFLFYFLYKV HFLLGIIIEL IAAYIIIGIR KPFEVSSSIY SSIKYTNLNA
AKETLKENTN IDVNDINREN IIKKTIEYSS ISVGEDYIYT SIFFLLGGLP LCFMYKVLCM
LSDISSDNNI AIDENRVKDK YGMFNINFAY YINMIPSIFA FLSYAVGSFL LGYDIKKAFR
VFKRDGNDNK ARLECAVAGA LDIELGGEYF KDSEIYDRIL VGDAINKLDS SYIVASNKIL
IMGAIIALFV LIVLKLLFML LGIIIF
//
