ID   D8J305_HALJB            Unreviewed;       353 AA.
AC   D8J305;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Methionine synthase {ECO:0000313|EMBL:ADJ15112.1};
GN   OrderedLocusNames=HacjB3_08645 {ECO:0000313|EMBL:ADJ15112.1};
GN   ORFNames=C497_14052 {ECO:0000313|EMBL:ELY34868.1};
OS   Halalkalicoccus jeotgali (strain DSM 18796 / CECT 7217 / JCM 14584 / KCTC
OS   4019 / B3).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halococcaceae; Halalkalicoccus.
OX   NCBI_TaxID=795797 {ECO:0000313|EMBL:ADJ15112.1, ECO:0000313|Proteomes:UP000000390};
RN   [1] {ECO:0000313|EMBL:ADJ15112.1, ECO:0000313|Proteomes:UP000000390}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B3 {ECO:0000313|EMBL:ADJ15112.1}, and DSM 18796 / CECT 7217 /
RC   JCM 14584 / KCTC 4019 / B3 {ECO:0000313|Proteomes:UP000000390};
RX   PubMed=20601480; DOI=10.1128/JB.00663-10;
RA   Roh S.W., Nam Y.D., Nam S.H., Choi S.H., Park H.S., Bae J.W.;
RT   "Complete genome sequence of Halalkalicoccus jeotgali B3(T), an extremely
RT   halophilic archaeon.";
RL   J. Bacteriol. 192:4528-4529(2010).
RN   [2] {ECO:0000313|Proteomes:UP000011645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B3 {ECO:0000313|Proteomes:UP000011645};
RA   Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A.,
RA   Eisen J.A., Facciotti M.T.;
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ELY34868.1, ECO:0000313|Proteomes:UP000011645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B3 {ECO:0000313|EMBL:ELY34868.1,
RC   ECO:0000313|Proteomes:UP000011645};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP002062; ADJ15112.1; -; Genomic_DNA.
DR   EMBL; AOHV01000038; ELY34868.1; -; Genomic_DNA.
DR   RefSeq; WP_008417448.1; NZ_AXZD01000008.1.
DR   AlphaFoldDB; D8J305; -.
DR   STRING; 795797.HacjB3_08645; -.
DR   GeneID; 9419530; -.
DR   KEGG; hje:HacjB3_08645; -.
DR   PATRIC; fig|795797.18.peg.1721; -.
DR   eggNOG; arCOG01876; Archaea.
DR   HOGENOM; CLU_040013_3_2_2; -.
DR   OrthoDB; 17656at2157; -.
DR   Proteomes; UP000000390; Chromosome.
DR   Proteomes; UP000011645; Unassembled WGS sequence.
DR   GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR   CDD; cd03311; CIMS_C_terminal_like; 1.
DR   Gene3D; 3.20.20.210; -; 1.
DR   InterPro; IPR002629; Met_Synth_C/arc.
DR   InterPro; IPR038071; UROD/MetE-like_sf.
DR   PANTHER; PTHR30519; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR30519:SF0; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR   Pfam; PF01717; Meth_synt_2; 1.
DR   SUPFAM; SSF51726; UROD/MetE-like; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          19..332
FT                   /note="Cobalamin-independent methionine synthase MetE C-
FT                   terminal/archaeal"
FT                   /evidence="ECO:0000259|Pfam:PF01717"
SQ   SEQUENCE   353 AA;  40261 MW;  775F91B97A002763 CRC64;
     MNNREQFRRP DHDNETFILT TVVGSYPKPK WLHRVRDLWE DEEANFDDEN WAEATDDAAR
     VITDEHERAG LDVLVDGEVR RNEMVEFFAH RIEGYEFNGP VKVWGHNYFD KPSVTREVAY
     DESWLVEEYE FAADLTDRPV KVPITGPYTL ANWSFNEAYE TEEELVYDLA DLVNEEIEKL
     VEAGARYIQI DEPALATTPD DHAIVGKALE RIAEDIHEDV YLGLHVCYGD YSRIYPEILD
     YPVDEYDLEL ANGDYEQLDV FTDHEFTGNL ALGVTDVHVA EVESVAEIKE NILKGLEVVP
     ADRLTISPDC GLKLLPRDIA YGKMANMVQA AREVEAEIDN GEIEVARTPA SAD
//