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Database: UniProt
Entry: D8J841_HALJB
LinkDB: D8J841_HALJB
Original site: D8J841_HALJB 
ID   D8J841_HALJB            Unreviewed;       322 AA.
AC   D8J841;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   24-JAN-2024, entry version 68.
DE   SubName: Full=D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein {ECO:0000313|EMBL:ADJ14154.1};
GN   OrderedLocusNames=HacjB3_03815 {ECO:0000313|EMBL:ADJ14154.1};
GN   ORFNames=C497_15478 {ECO:0000313|EMBL:ELY34664.1};
OS   Halalkalicoccus jeotgali (strain DSM 18796 / CECT 7217 / JCM 14584 / KCTC
OS   4019 / B3).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halococcaceae; Halalkalicoccus.
OX   NCBI_TaxID=795797 {ECO:0000313|EMBL:ADJ14154.1, ECO:0000313|Proteomes:UP000000390};
RN   [1] {ECO:0000313|EMBL:ADJ14154.1, ECO:0000313|Proteomes:UP000000390}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B3 {ECO:0000313|EMBL:ADJ14154.1}, and DSM 18796 / CECT 7217 /
RC   JCM 14584 / KCTC 4019 / B3 {ECO:0000313|Proteomes:UP000000390};
RX   PubMed=20601480; DOI=10.1128/JB.00663-10;
RA   Roh S.W., Nam Y.D., Nam S.H., Choi S.H., Park H.S., Bae J.W.;
RT   "Complete genome sequence of Halalkalicoccus jeotgali B3(T), an extremely
RT   halophilic archaeon.";
RL   J. Bacteriol. 192:4528-4529(2010).
RN   [2] {ECO:0000313|Proteomes:UP000011645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B3 {ECO:0000313|Proteomes:UP000011645};
RA   Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A.,
RA   Eisen J.A., Facciotti M.T.;
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ELY34664.1, ECO:0000313|Proteomes:UP000011645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B3 {ECO:0000313|EMBL:ELY34664.1,
RC   ECO:0000313|Proteomes:UP000011645};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR   EMBL; CP002062; ADJ14154.1; -; Genomic_DNA.
DR   EMBL; AOHV01000040; ELY34664.1; -; Genomic_DNA.
DR   RefSeq; WP_008417874.1; NZ_AXZD01000005.1.
DR   AlphaFoldDB; D8J841; -.
DR   STRING; 795797.HacjB3_03815; -.
DR   GeneID; 9418561; -.
DR   KEGG; hje:HacjB3_03815; -.
DR   PATRIC; fig|795797.18.peg.767; -.
DR   eggNOG; arCOG01757; Archaea.
DR   HOGENOM; CLU_019796_1_0_2; -.
DR   OMA; HVAGWSP; -.
DR   OrthoDB; 168224at2157; -.
DR   Proteomes; UP000000390; Chromosome.
DR   Proteomes; UP000011645; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd05300; 2-Hacid_dh_1; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR   PANTHER; PTHR10996:SF275; DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003719}.
FT   DOMAIN          26..318
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          113..287
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   322 AA;  34952 MW;  45A4C08173820073 CRC64;
     MTEERPDVVV LREGTEGLST EPYAEELRER LPEYEVRRAR TPSEERDLIE GARVATGVRI
     DEELLSHATD LELFACAFAG TEHLPTEALR ERGIALTNAG GIHAPGLAEG VLGNMLVFAR
     RLHEGWRRKE NREWRHFQSG ELTGSTVTIV GLGSIGEALT QRLEGMEVET IGVRYSPEKG
     GPTDEVIGFD EAALHDALAR TDYLVIACPL TDTTRGLIGE DEFATLPPEA VLINTARGPI
     VETDALVGAI QTNSIRGAAL DVTDPEPLPP DHVLWGFENV LITPHTGGHT PKHWDRLAEI
     VAGNVAALDS GGDLENLVFA PE
//
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