ID D8L203_HUMAN Unreviewed; 139 AA.
AC D8L203;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Trim5alpha {ECO:0000313|EMBL:ACY29371.1};
DE Flags: Fragment;
GN Name=TRIM5 {ECO:0000313|EMBL:ACY29371.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ACY29371.1};
RN [1] {ECO:0000313|EMBL:ACY29371.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ml2139 {ECO:0000313|EMBL:ACY29371.1}, and Ml2178
RC {ECO:0000313|EMBL:ACY29373.1};
RX PubMed=20588169; DOI=10.1097/QAD.0b013e32833b5256;
RA Price H., Lacap P., Tuff J., Wachihi C., Kimani J., Ball T.B., Luo M.,
RA Plummer F.A.;
RT "A TRIM5alpha exon 2 polymorphism is associated with protection from HIV-1
RT infection in the Pumwani sex worker cohort.";
RL AIDS 24:1813-1821(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family.
CC {ECO:0000256|ARBA:ARBA00008518}.
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DR EMBL; FJ561493; ACY29371.1; -; Genomic_DNA.
DR EMBL; FJ561495; ACY29373.1; -; Genomic_DNA.
DR AlphaFoldDB; D8L203; -.
DR PeptideAtlas; D8L203; -.
DR ChiTaRS; TRIM5; human.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19761; Bbox2_TRIM5-like; 1.
DR CDD; cd16591; RING-HC_TRIM5-like_C-IV; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF416; TRIPARTITE MOTIF-CONTAINING PROTEIN 5; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 15..59
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 90..132
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT NON_TER 139
FT /evidence="ECO:0000313|EMBL:ACY29371.1"
SQ SEQUENCE 139 AA; 15825 MW; 06262DCB7420A22A CRC64;
MASGILVNVK EEVTCPICLE LLTQPLSLDC GHSFCQACLT ANYKKSMLDK GESSCPVCRI
SYQPENIRPN RHVANIVEKL REVKLSPEGQ KVDHCARHGE KLLLFCQEDG KVICWLCERS
QEHRGHHTFL TEEVAREYQ
//
