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Database: UniProt
Entry: D8LD25_ECTSI
LinkDB: D8LD25_ECTSI
Original site: D8LD25_ECTSI 
ID   D8LD25_ECTSI            Unreviewed;       333 AA.
AC   D8LD25;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   22-NOV-2017, entry version 41.
DE   SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:CBN78392.1};
DE            EC=1.1.1.31 {ECO:0000313|EMBL:CBN78392.1};
GN   Name=3HIDH {ECO:0000313|EMBL:CBN78392.1};
GN   ORFNames=Esi_0113_0006 {ECO:0000313|EMBL:CBN78392.1};
OS   Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC   Eukaryota; Stramenopiles; PX clade; Phaeophyceae; Ectocarpales;
OC   Ectocarpaceae; Ectocarpus.
OX   NCBI_TaxID=2880 {ECO:0000313|EMBL:CBN78392.1, ECO:0000313|Proteomes:UP000002630};
RN   [1] {ECO:0000313|EMBL:CBN78392.1, ECO:0000313|Proteomes:UP000002630}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX   PubMed=20520714; DOI=10.1038/nature09016;
RA   Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA   Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA   Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C.,
RA   Brownlee C., Carrano C.J., Charrier B., Cho G.Y., Coelho S.M.,
RA   Collen J., Corre E., Da Silva C., Delage L., Delaroque N.,
RA   Dittami S.M., Doulbeau S., Elias M., Farnham G., Gachon C.M.,
RA   Gschloessl B., Heesch S., Jabbari K., Jubin C., Kawai H., Kimura K.,
RA   Kloareg B., Kupper F.C., Lang D., Le Bail A., Leblanc C., Lerouge P.,
RA   Lohr M., Lopez P.J., Martens C., Maumus F., Michel G.,
RA   Miranda-Saavedra D., Morales J., Moreau H., Motomura T., Nagasato C.,
RA   Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F., Pommier C.,
RA   Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA   Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C.,
RA   Segurens B., Strittmatter M., Tonon T., Tregear J.W., Valentin K.,
RA   von Dassow P., Yamagishi T., Van de Peer Y., Wincker P.;
RT   "The Ectocarpus genome and the independent evolution of
RT   multicellularity in brown algae.";
RL   Nature 465:617-621(2010).
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DR   EMBL; FN647822; CBN78392.1; -; Genomic_DNA.
DR   ProteinModelPortal; D8LD25; -.
DR   HOGENOM; HOG000219610; -.
DR   InParanoid; D8LD25; -.
DR   OMA; MILGVTM; -.
DR   Proteomes; UP000002630; Chromosome LG23.
DR   GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR029154; NADP-bd.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 2.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002630};
KW   Oxidoreductase {ECO:0000313|EMBL:CBN78392.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002630}.
FT   DOMAIN        1    186       NAD_binding_2. {ECO:0000259|Pfam:
FT                                PF03446}.
FT   DOMAIN      189    303       NAD_binding_11. {ECO:0000259|Pfam:
FT                                PF14833}.
FT   ACT_SITE    195    195       {ECO:0000256|PIRSR:PIRSR000103-1}.
SQ   SEQUENCE   333 AA;  34637 MW;  DFE5F12729234A35 CRC64;
     MGSCMATSLV RAGHDVLLFD VDARKAKAVA ADTGATAASS LKEVAQASLF IVTMLPNTSN
     VEKVYLGGTS HHRREGATTD GPSLSPEKQR VRQAGNGDTE TEQGLLDWVR SGTLVVDSST
     IDPLASRRVN AIAEIKGVTM VDAPVSGGVP AAANATLTFM VGGTDEGLEL ARPLLMAMGS
     KAVHCGDAGA GCIAKVCNNL SLAISMIGVA EAMSLGSKMG MDAKVLASVL NSSTARCWSS
     EAYNPFPGVM ENVPSSRGFQ GGFAASLMEK DLHLALQAAS ESSQSLPMGA HAHQLYSQLC
     NEGWVVSSNN TCWTCVKPLS TFNGRVCVVF DNH
//
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