ID D8LI41_ECTSI Unreviewed; 1371 AA.
AC D8LI41;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=BEACH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Esi_0201_0047 {ECO:0000313|EMBL:CBN79377.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBN79377.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBN79377.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
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DR EMBL; FN648378; CBN79377.1; -; Genomic_DNA.
DR STRING; 2880.D8LI41; -.
DR EnsemblProtists; CBN79377; CBN79377; Esi_0201_0047.
DR eggNOG; KOG1786; Eukaryota.
DR InParanoid; D8LI41; -.
DR OrthoDB; 5478899at2759; -.
DR Proteomes; UP000002630; Chromosome LG28.
DR CDD; cd06071; Beach; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 646..743
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 774..1073
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 1207..1248
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1263..1304
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1371 AA; 142867 MW; 340C0770401BBC04 CRC64;
MLEPPPPPLV DGGGAEGGGG GGGGSALYPA ADEEAAAEGT RAQAFALWLT GGGQEVAMKE
GFERATERSY TLIPHVSSVE GLTAALSRAE LAANGGGYGY GAAASGPGSS ALSRLGSGVG
GALGALAAGP NRKTITVDRA IQRADMIART YERVATSHGR WVWTGADDLA WASRRWRVQL
SGLRGKVSLW EGGLFGRLMC SPEAITALRP GTDGGQDGVD GERYKLDMDE GPERSRLQLR
PNRDFYDTYE VMAPALPAAS TAAPAAAGVA QEAAAAADTQ GAPSSSAAAM ATTDNEPSAS
VAAVAAAATA AAVVTSPIVP SVAAGAGNEV SPPAAGSAGA AAVAAAKSPD RPVPPPLSPS
TNVASVGKSV VRGGGQVADI AALVRSMSVS VGVGGKGGPK RKQQLTSVFD LDDTDCSALL
ELEELRLEVE DAPDGAEDES FRQPSDSTDA DLRSPVDNAD RLSPSLGSEG ARQVPPTPAS
QSEGGSIAEV GDGEIGAAAR RAGVEHGGRD RSPGRGFSLG ESDLMDGDTS EMSALDDDHT
VHGSEISGLD AQDMDEADEE SGEGGGGSGG VCPAGSSVAG RGRSPRRATA QKESGSAGEG
GVGGARAAEL KQGHGRDSME PPEASGDGLG GTTEAPTSSG VGSTTTATAM STATTPAAPA
GPGTLARKEG WSDRELLQGL MKPEDNPAIA AHDRFALDHV HAVYKRRYQL RDCGLEIFDV
LGRSILVSFA ARVQQEEVLT FLLARGLPAS IFAKGKHKLR LASGSSHAQA RAAYKKFMQA
ERISWTKKWQ SGRCTNFAYL MALNTLAGRS FNDLTQYPVF PWVLCDYVSE ELDLENPRVY
RDLSKPMGAI GETRARQFRE RYEAVIEAAE ETGQDPNPPP FHYGTHYSCA GYILHYLLRL
EPFTKLALAL QGGRFDKADR LFRDVRSSWE SASRENLQDV RELTPEFFNL PEFLVNSNEF
DFGFTQKGQG VHDVVLPPWA KGDPAEFIRL HRKALESPHV SKNLHSWIGL IFGCKQRGPE
AVEAQNVFVH LTYEGEVDID SIQDPLLRDA ALAQIHNFGQ TPSLVLKKAH PQRELPPVVR
ISGADGSRTA DPAAVEWHTT LTPPLCIVGA PDAVALRPVA LSNIGSSWQC NVGGAVGVAG
GAGVGDARII RDKIAGVGVG AIMLPKSPDK YLRFGGPSRG VSFFQTAGGG TASSSKATPD
RLLSSHESLH LTAVTAAACS VDGSLLLTGA LDGTCRLWSV VTLQSRSSGL GQVSRMLDLA
ASLGRHAGPV TCATVCMGSG SAVTGGADGK VLVWDIRRKN FVRELPGHRS GISSVEINKT
NGNVVTLSGS ELRVWNVNGR LLASCSVTAL RRGAPPTCAV STNCPDWQEI F
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