ID D8LI89_ECTSI Unreviewed; 1411 AA.
AC D8LI89;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Tubulin binding {ECO:0000313|EMBL:CBN75911.1};
GN ORFNames=Esi_0206_0038 {ECO:0000313|EMBL:CBN75911.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBN75911.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBN75911.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
CC -!- SIMILARITY: Belongs to the TUBGCP family.
CC {ECO:0000256|ARBA:ARBA00010337}.
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DR EMBL; FN648383; CBN75911.1; -; Genomic_DNA.
DR STRING; 2880.D8LI89; -.
DR EnsemblProtists; CBN75911; CBN75911; Esi_0206_0038.
DR eggNOG; KOG2000; Eukaryota.
DR InParanoid; D8LI89; -.
DR OrthoDB; 1222752at2759; -.
DR Proteomes; UP000002630; Chromosome LG17.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005815; C:microtubule organizing center; IEA:InterPro.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR InterPro; IPR041470; GCP_N.
DR PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR PANTHER; PTHR19302:SF70; GAMMA-TUBULIN COMPLEX COMPONENT 6; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
DR Pfam; PF17681; GCP_N_terminal; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630}.
FT DOMAIN 290..617
FT /note="Gamma tubulin complex component protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17681"
FT DOMAIN 1105..1377
FT /note="Gamma tubulin complex component C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04130"
FT REGION 623..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..643
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..848
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..983
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1190..1204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1411 AA; 147718 MW; CEAB1DD450F6A404 CRC64;
MNKGPSLDEG LELMATAPLS PANWTRLCES SATAGDDTVV AHGSGGAPAA PVMAVEHVEG
NGVRRLNLSM PVVAASQVNG GAPLVHGGLD LCGALSQANI DARSPAVREL RLALSFPDLE
EGLPTDLLEA AKLHKPPRRP ADHPVGDGYQ HGLPERTIGK EANVLWQSPR GVLRSPKGKC
GRMLPIDEFA PPWGSENGGH LSGVIHDAAN HEVAALELEP VGWERTEADW NDPSFPKWAL
ACAPLVTGEG GGPSSKRAFE LCYREHFEWA GLGGSLGEAD TTAKAEVEVV RRALAALQGV
PSGYFWYDET HAQMRVCGHV GQDGAVEEAP LMPPRVAGLS PGALSSLLEE FAMAGTWYRR
VQEFVRCLVN TPSSNGQVAR AFGIELRRQL TEVQSALLGV TMELEGLGWN DSDSACLHGT
QDTPLNEQRC CSLAGILAHT TQLRRAVGAL AEICGLSEDD LRSAGGVRAV FNAFPRGSSL
LTYLYKAAEV RVASKPGGES TCFFERVMAE GDSALALLSS AATPYLSMLG RWIWSGEMWA
EDDPCEEFPL RCRERLTGSD TSKATKEPWT EDGGGSFMSL AFCENGAAGV PCFLAGGVLH
AAARTGKLLR MLKAAASSGG AVSRARDSST RCGKRDEDGN DTWGWERTVT GGREVGSREA
PAEKRPPAAV YGGQGVLSFL DPPTSEAEAF AAAAITERYR VLGKEADARA ARARWKRQRS
ARVVAARASL KMLYEEEMHR WEGMAAGAGP GTESHSTTAG HEAGVSDADN ADNTLHGVEA
SSADAVGGGP DSSDGTGGGQ MGHVVEQAVA EGELNADSDG SRVEVRAEEE VGTIKRGRDS
EGSGAPDKRP GGDDANISPV GILDAPSGHM AGVAEAVGSE GNEAQGMKFS HVTIVQEPGG
KSHGVSGAFA ANIDGGGDDA TTSGPLPGRS GVRRIVQEPG GSSSAVSRIL SHDSADGVDK
APRAGRIAEG EDSRERDNDN NDGETVRWTW GRMGMLPFRW RSSCADAVDW RRSSNLDAAF
AASALATGLD SVPLAETFRY EVDPTCGGIL GSGPATGSLD LGRRAESSGM TGGAVHSATA
TITTTTTRAE LSLSSSLSVQ EEELYSPVAL SFVSPVLEVK WPVGVLLPTG VLHTYGSIHR
SLIRHQLALH RLRRLRLVLR ELDACLDAAS GGGIGGVGGG GRRSGRGGGS GGGDSSSGSS
RRQRGGARVS WDRGRLHWLH LFRHEMQHMA DSLQSYFAEQ AEADWPDLRR SLAVAGGGAA
RGGGGGLAAL VAAHSRYITK MQRYMFLGTD RQGAVARGSI GEFYAVICTV GRITDGLLSS
KPSRSPPASV ADLSNGTCTG SAVGEMVLPD EAFAELAAVR EKFDAARRGL CAALSEICAA
GGGTRARPLL SVIGYGGYGG DDFVVAADLS R
//
