ID D8LKT2_ECTSI Unreviewed; 439 AA.
AC D8LKT2;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Signal peptidase I (SPase I) (Leader peptidase I) {ECO:0000313|EMBL:CBN80065.1};
GN ORFNames=Esi_0031_0025 {ECO:0000313|EMBL:CBN80065.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBN80065.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBN80065.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
CC -!- SIMILARITY: Belongs to the peptidase S26 family.
CC {ECO:0000256|ARBA:ARBA00009370}.
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DR EMBL; FN648498; CBN80065.1; -; Genomic_DNA.
DR AlphaFoldDB; D8LKT2; -.
DR STRING; 2880.D8LKT2; -.
DR EnsemblProtists; CBN80065; CBN80065; Esi_0031_0025.
DR eggNOG; ENOG502S8VM; Eukaryota.
DR InParanoid; D8LKT2; -.
DR OrthoDB; 5485568at2759; -.
DR Proteomes; UP000002630; Unplaced LGUn.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd06530; S26_SPase_I; 1.
DR Gene3D; 2.10.109.10; Umud Fragment, subunit A; 1.
DR InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR InterPro; IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
DR InterPro; IPR019533; Peptidase_S26.
DR PANTHER; PTHR43390:SF1; CHLOROPLAST PROCESSING PEPTIDASE; 1.
DR PANTHER; PTHR43390; SIGNAL PEPTIDASE I; 1.
DR Pfam; PF10502; Peptidase_S26; 1.
DR PRINTS; PR00727; LEADERPTASE.
DR SUPFAM; SSF51306; LexA/Signal peptidase; 1.
DR PROSITE; PS00501; SPASE_I_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..439
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003117286"
FT DOMAIN 215..429
FT /note="Peptidase S26"
FT /evidence="ECO:0000259|Pfam:PF10502"
FT REGION 315..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 237
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
FT ACT_SITE 292
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
SQ SEQUENCE 439 AA; 46271 MW; 34377FC72A5271A5 CRC64;
MYGACAKLVP AALMVLAHMH FARALISPRP TASLSWDQPV LRGRPSVWSE DGYGSSSWKH
QRMRRGRRCG NFHQRQRTRA PALAMLFEKR PEERALGDVL IPEDSSGGAG GGSGDDAIGV
SVEPPGFLKR VFSVPKNVRR TAAAGDVVVP VIGARDGWGG IRQRLADQGI YPGVEYRILE
RGDWPVRVPA REFPVMLTPF SYNAATAWAA FTTSLSLLSV GFVLSQALTL SVINSHSMEP
TLQVGDVVLV EKVSRSFLVK PNDIVYFRPP PVLQDIVSRA GGSLSPSDLF VKRVAALSGD
TVTVGADGRV DVRAAAGGGG GNTRLPKGTN RADNGGGAAG GDSDSILGDG VAGQEGSAAA
VAAAKGGALA EEKVALPDSV LQRIARLDEK VLPSGSVFVL GDNPAASMDS RVWGQLDKGE
IVGHALLRVF PPRSFGLLQ
//
