ID D8LQB6_ECTSI Unreviewed; 3490 AA.
AC D8LQB6;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 08-NOV-2023, entry version 60.
DE SubName: Full=Dynein heavy chain {ECO:0000313|EMBL:CBN78680.1};
GN Name=DYHC2 {ECO:0000313|EMBL:CBN78680.1};
GN ORFNames=Esi_0006_0001 {ECO:0000313|EMBL:CBN78680.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBN78680.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBN78680.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
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DR EMBL; FN648818; CBN78680.1; -; Genomic_DNA.
DR STRING; 2880.D8LQB6; -.
DR EnsemblProtists; CBN78680; CBN78680; Esi_0006_0001.
DR eggNOG; KOG3595; Eukaryota.
DR InParanoid; D8LQB6; -.
DR OMA; MAPNAKL; -.
DR OrthoDB; 312149at2759; -.
DR Proteomes; UP000002630; Chromosome LG04.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630}.
FT DOMAIN 710..813
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 993..1123
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1355..1510
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 2008..2038
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2242..2307
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3490 AA; 392775 MW; 6EFB66D1FFBB8545 CRC64;
MSSQTGTGTQ HAGPTFLQEE IDQKSVIRLT WRKLLELCER VTDMLHSVQG KYKKQLVKNV
KELKEDVRKF RREWETSGPM VQGISPLEAV ERLRRFKEEM QLRERTAEMY TAGEELFALK
ITAHPDLIKI KKESSLLDQL YGLYMDVLQT LERYREVLWT SAGDELVAMS EMVASFDSRC
RKMPKKLREW EAFQVLLRKI TDFQEVLPII ENLRKPSIKP RHWQEVMDIT KTNFPYESEN
FSLSNIMDSP ILQFKDDIEE ICEGADKQLS IAEKLDDITD QWDHAAFEFT PWKSRGVPVL
KAYGVIIEEL EDAQLQLQTL LSMRHVTPFR EIVQNKLNDL SNATDSLELW VKVQLLWTSL
ESVFMGGDIA KQMPIEAKKF VKIDKDWAKT MIKAEETEKV IMCCASETLC TTLPVLFVEL
EKCQKSLEGY LEQKRSRFPR FYFVSNPVLL LVLSQGSDPV QMQPYYEKVF DSISQVVHDK
KEKSSIISMV NIAGSDEETI SFSKPVKATG NIEDWLGALE KGMQVSLKSL AELAAVQCTL
MPLRQFVDCS CGQFALLGLQ FSWTAQCQEA LDKCRTNKSI MSETNRGQLG VLQEMSSWCL
QDLGTKMNRT KIETLVTIQV HQRDVFMDLT RLYKERKIHN SMDFEWLKQA RFYWRPGEDD
AHGAGSCAIS ICDVDFKYRF EYLGCKERLV ITPLTDRCYI TLSQALGMFL GGAPAGPAGT
GKTETVKDLG RSLGNFVVVT NCTDQQRYTD MAKIFKGLCQ AGLWGCFDEF NRIELPVLSV
VAQQVLAITN AKRVGAKEFV FPGDSQVIGL KRDVAYFITM NPGYQGRQEL PENLKVLFRS
VAMMVPDREI IMKVKLCSVG YQGFSDLARK FNVLYALCEQ QLSKQKHYDF GLRNILSVLR
TAGKTKRDNL DENEDLLLMK TLRDMNLSKL IAQDVPLFLS LLGDLFPAVV AGASGDAHAE
VESAAKSFID KEGLIAHPSW CLKVIQLYET TLVRHGVMMV GPPGSGKSST ISTLQSALTK
TTGVQHKPIR MNPKAIRAEE MFGETNKASG EWVDGVFAAM WSKFNDRNRK DMQWIICDGP
VDAIWIENLN TVLDDNKILT LANGDRIPMT DNVKLIFEVE DLRNASPATV SRAGIIYVSD
SDLDWQPVME SRLKKLPPGR GDILREFFRK YVGECLGPKE PGHLFDFITR TCRPVMNCTR
VGQIEATIRL LSEMLESSDM SQSPEDAQGE LERLFLFSVS WALGGLLEPD ERVKFDQYLQ
QLCPENMPSS GGAAAAAAAA ANDGDSVSGN STISASSGLT VFDYSVNLDT MAWEPWVVPA
WEYPKVPAEV DFQRLLVPTV DSTRALAIIN HLQKQRHPVL MVGGSGTAKT TTALMYFDSL
TNDSMMVKRI NFSSATTAGM FQSTIEGELD KRGGKNFGPP SGCGMTVFLD DVSMPEVNEW
DDQPTLEVVR QLVETGGFCF LDKDKRGDLK VIEDLQYVGA MNHPGAGKND IPNRLKRHFF
IFNMIVPPEE SINAIYGQMV EGRFPAQERR STFHLFSERL PAATTALWRW MRAKMLPSPS
KFHYTFNMRE LSRVFQGLLR APKDSIPTEV CLMKLWRHEC CRVFADKLTT IEDKEAFQKE
LDHQTALLGR AVLETPEGRL LTYEMVTGES PGEDEVSPPT DEISLLKAIT QEAFFVDFLR
TDEYDEDGVL IQAAPKVYEE GPSLVNLRAI VQGFAEQYNL DFPANRMDLV LFDDALRHLI
TVSRILGMPR GNMLFVGVGG SGKQSLTRLA SYIAGNFTFQ ITITKAYNLN SFMDDMRCLY
KKCGQEGKNA TFVLTEAEMK DETFLEIMNS FLMTGEVPNL FPKDELHMMA AEIRPFAIST
RPDFVDTPEN LARCFVDRVR ANLHCVICMS PVSVKFPERA RKFPGLVNGC TINWFLSWPA
EALVAVSDGY IGNAPIECSA EVHKELVTHM GMVHRMVVES CADYFVQMRR RVYQTPRSFL
SFLGSYKDLY LTKKEQVDVK SKRVIVGLDK LKKGASDVEL MKVQLKEEEV KLKEADLATT
KMLSKLEVSS MAAKKEADAV AVIKEACMAD ARRIAGEKED AEEDLAQAKP FLEEAERAVE
SIKAGDLNEL KKLQKPSDII KLIFDCVGLL KMEKVQPVQV DEVTIGIGKE KQTLPFLKDS
FKYMQAGMLS DARFLQSIFA FSQNEKDFIN DETVELMAPY LELEGFNPAV ARNASKAAEG
LCTWCRAMTY YHEASKVVKP KLEALRIAEV KLQDAQKELE EAESKLQNCQ DVLTKLQTKF
EAQMAKKRAI EENAARTRSR MEQATALIVG LGGERTRWTE DSRKFADTKR RLVGDVALSC
AFVGYCGPFN QEFRDHLVKT RFSDDLVSRG IPLTKGLDLT SFLVDMGTIG DWNLDGLPTD
PLSIQNGILV TRSSRYPLLI DPQGQALNWI RRHEKDRLPA SGVTSFSSDK LRDTLEYCMM
EGKALIIAGV EEDIDPMLTP VLEKQIVVKA RSKYINVADK MCEFSDSFML YMTTRLPNPH
LSPENQAKTT VVDFTVTQKG LEEQLLGGVI QKEQKSLEEQ LKNVLEEVTN NTKALMALDQ
LLLERLSANT GNLLDDEELI GALAETKKKA VQVRDKLVAA GEMREGIDEK REQYRPVATR
GAVMYFTIVD LSLVNVMYQT SLDQFQTLFT RAMDVADKAS LASKRVWNII ETMTFNVYRY
ISRGLYEQDK LSFKLILALK ILLTARRLDQ SDVTLFIKGG AALDLNAVKP KPYLWLADPA
WLNAIQLSRD NVMFKSLPDE IIRNEAAWKL WYAENEPEEI PVPYFEGRLA ADPSVGAFYR
LLLVRSLRED RTLLCVNNFI RLTDTVEHAG SRLPAMGPRF AEPLTDTVES VYNEMDCSTP
VIYLLSAGAD PTDSIEGLAR KKKTDVACVS MGEGQSVVAS RAIAAATVNG SWVLLQNCHL
GLDYMETMED YLQTLPACHT DFRLFITSEP HPKFPIGLLQ MSIKVTNEPP KGLRAGLLRS
FTVIVDQDKL ERVDSSQWRA LLYSLCFLHS VVQERRKFGS LGWCIPYEFN DGDLNACATF
LEKHLYSGSV SWPTVQYMVG EVQYGGKITD DLDRRLFKAY TETWMGPPAL SASFCFNPGV
PMQGGPQFKY VIPDSQEVED YIAFIQTFPG IDGPEVFGLH PNADLTFRNK EGQQLLATLM
ETQPKQATGG TGRSREDMVL EKCTELLLAV PEGFTEASYL ECIAAQGGLG VPLNIFLMQE
VQRLQLVIIN VGGMLKTLLQ AIRGEVVVTE DLMSAINAVY DARVPRQWVF SYGGDEISWM
SASLGLWFSS FTARNEQLAT WLTGGRPPCF WLTGFFNPQG FVTAVQQEVT RAHKADRWSL
DGVVLHTEVT EFEKSEQVKA PPKEGVYIHG LYLDGAQWNR SENSLVESKP KELFSSVPVM
YVTAVTKAQR KALSGDYGPH GGFDCPVYKY SLRTDKYIIF LVTLAARSKH PSHWTLRGVA
LLCGSGDSVQ
//
