ID   D8LQF8_ECTSI            Unreviewed;      1197 AA.
AC   D8LQF8;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=AMP-dependent synthetase/ligase domain-containing protein {ECO:0000259|Pfam:PF00501};
GN   ORFNames=Esi_0006_0085 {ECO:0000313|EMBL:CBN78722.1};
OS   Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC   Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC   Ectocarpales; Ectocarpaceae; Ectocarpus.
OX   NCBI_TaxID=2880 {ECO:0000313|EMBL:CBN78722.1, ECO:0000313|Proteomes:UP000002630};
RN   [1] {ECO:0000313|EMBL:CBN78722.1, ECO:0000313|Proteomes:UP000002630}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX   PubMed=20520714; DOI=10.1038/nature09016;
RA   Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA   Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA   Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA   Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA   Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA   Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA   Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA   Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA   Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA   Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA   Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA   Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA   Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA   Yamagishi T., Van de Peer Y., Wincker P.;
RT   "The Ectocarpus genome and the independent evolution of multicellularity in
RT   brown algae.";
RL   Nature 465:617-621(2010).
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DR   EMBL; FN648818; CBN78722.1; -; Genomic_DNA.
DR   AlphaFoldDB; D8LQF8; -.
DR   STRING; 2880.D8LQF8; -.
DR   EnsemblProtists; CBN78722; CBN78722; Esi_0006_0085.
DR   eggNOG; KOG1178; Eukaryota.
DR   eggNOG; KOG4649; Eukaryota.
DR   InParanoid; D8LQF8; -.
DR   OMA; HECAAGE; -.
DR   OrthoDB; 76882at2759; -.
DR   Proteomes; UP000002630; Chromosome LG04.
DR   Gene3D; 2.40.10.480; -; 2.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR   InterPro; IPR002372; PQQ_repeat.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR44394; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR   PANTHER; PTHR44394:SF1; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13360; PQQ_2; 1.
DR   Pfam; PF13570; PQQ_3; 2.
DR   SMART; SM00564; PQQ; 7.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..1197
FT                   /note="AMP-dependent synthetase/ligase domain-containing
FT                   protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003117413"
FT   DOMAIN          20..377
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   REGION          137..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          643..666
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..173
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1197 AA;  124783 MW;  BC3B6B7219EC2DE2 CRC64;
     MVSYVSLLLL LSPPSFLPQP ISFVQLHSRA VAIADALTGA EGLGSQRPAT PTFTVAILCG
     KSDIAEICAV LAVILAGGCF VPIDDKLPLP RLSEVFRDAQ PDAIVTTRSF LAGERAAGGS
     GIPAVIEQQG CQILHLEDSG KPSESRETVD TFRESKAHDE NGESEESIGK HSCGKRVPRS
     SACTASTAAR HANVVPDDEG PVADKGNSSL AGQACPGPLE NDTRPGAASE SKGLADSGLY
     DRKELHPCPV PCDEEDLLYI LYTSGTTGPQ KGVRGTRSGA VNRILFGWSL CPFRGDGELV
     CRRTPSCFVD FVAEVFCPLL AGVPLFLPTP GAHADPLLLV PALAEVKATR ITLTPSLLAS
     MLRTTSSDTE TLLPDVHVKV RGVRVSPEAV EVVACRASGL PVGAFAVVYD HGMDTDGSAG
     GDSSAVTKAA IATRSPDRGR LWGFFEPNGV QVNNEGLAKL RLQLAAVLTT AQLPAVLVPV
     VGRFPLTTSG KVDKRALLRE HWKQVEALGG RPVASAEGVD AYLPFPTDVT TQKVGTLAAA
     REAVARAIVS VLPDARASIA SWLINLEESA PGSSNCSNMT FASTLHDILE KERHAEETKN
     SSGTAIGLAA AGLAATGAGQ RKPPVPPACP GLLSPAVADA SAAGFQSTSS PGRKRQRLDF
     EKRDQTTHSR SFLALGRAAS GLPKTVACLG EVGDRVGDGS GLKGAKADLE VRWSSCLTKC
     IDATPLVFLP KSEREIVGRS RTGGVDNAGG MVAEAPSQFA SPESVGPSSY CPSVVGTQRL
     GGRVKEAGKS TTCGDARIST SHVSSGTVYI GSHSGEFQAL DLETGDREWL FTAGGRIESG
     AACSCDGSTI FVGCHDGRLY AIDRRMGVLS WSFETGDAIK CTPICMPEAP SSDLTNRGAR
     KEGELVDWGT VVFGSHDGVL RSLWEADGVL RWNFDCGGAL FASPAHDAEA RVVYAATTKG
     RVVALDNSAL VAFAGTEAAG SVDHNRKLTG SSTTQPTLLW DTYLPAPVFS SPAVCSASGT
     VVLGCVDGGL YCVSSVGEQV WVCRRGDKPV FSSPCILPPP CKEMGGDVNN ASGTRVIWGC
     HDGVVRCRSG VDLAWETDVR RGQPVFSSPC FAAVACEGCA LLCPLVLACS VPGLISALSL
     ADGEVLGEIQ LPGEIFSSAV VAGPSVVVGC RDNRVYVLDI LMTCPKCVQT KAVATVC
//