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Database: UniProt
Entry: D8LY89_BLAHO
LinkDB: D8LY89_BLAHO
Original site: D8LY89_BLAHO 
ID   D8LY89_BLAHO            Unreviewed;       338 AA.
AC   D8LY89;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=Malate dehydrogenase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=GSBLH_T00000858001 {ECO:0000313|EMBL:CBK20544.2};
OS   Blastocystis hominis.
OC   Eukaryota; Sar; Stramenopiles; Bigyra; Opalozoa; Opalinata; Blastocystidae;
OC   Blastocystis.
OX   NCBI_TaxID=12968 {ECO:0000313|EMBL:CBK20544.2};
RN   [1] {ECO:0000313|EMBL:CBK20544.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Singapore isolate B {ECO:0000313|EMBL:CBK20544.2};
RA   Wincker P.;
RT   "Sequencing and annotation of the Blastocystis hominis genome.";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC       {ECO:0000256|ARBA:ARBA00009613}.
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DR   EMBL; FN668639; CBK20544.2; -; Genomic_DNA.
DR   RefSeq; XP_012894592.1; XM_013039138.1.
DR   AlphaFoldDB; D8LY89; -.
DR   EnsemblProtists; CBK20544; CBK20544; GSBLH_T00000858001.
DR   GeneID; 24918146; -.
DR   InParanoid; D8LY89; -.
DR   OMA; CATLANQ; -.
DR   OrthoDB; 501358at2759; -.
DR   Proteomes; UP000008312; Unassembled WGS sequence.
DR   GO; GO:0016615; F:malate dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR   Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR010945; Malate_DH_type2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23382; MALATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR23382:SF3; MALATE DEHYDROGENASE, CYTOPLASMIC; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR   SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|PIRSR:PIRSR000102-3};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003369};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008312}.
FT   DOMAIN          5..150
FT                   /note="Lactate/malate dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00056"
FT   DOMAIN          183..326
FT                   /note="Lactate/malate dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02866"
FT   ACT_SITE        191
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
FT   BINDING         10..16
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT   BINDING         41
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT   BINDING         103
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT   BINDING         127..129
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
SQ   SEQUENCE   338 AA;  37196 MW;  E6A20C71D6491696 CRC64;
     MKCLRVVVSG AAGLIGYSLS GLLGDGTVFG TDRLVELVLH DIPRCEQKLV ALKAELEDCA
     FPYVSSIEFF TDPLNAFRDA DIVFFLASLP LTGPDRASLL EKNINIYIEF GKALEQVASR
     TCKSIVVANP ANTLAYVLMQ TAPSIPRSNF AALNRTDHNR TRSLTLDACR KAYDASLQLS
     DLSDTFVWGN HGNTMFADLT HAKIRGIPLM EAIPDRELWE KTLPEQVERR GWVLMELRGG
     VSSVLSVARA SVDVARDWCL GTNGKRITMA VCSDGNCYGV EEGLIFGMPV VCENGEWKCV
     EGLKIAENVR KHIEITTQDL KKEVEIADAA IERAKNNN
//
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