ID   D8M0N2_BLAHO            Unreviewed;       500 AA.
AC   D8M0N2;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN   ORFNames=GSBLH_T00001760001 {ECO:0000313|EMBL:CBK21621.2};
OS   Blastocystis hominis.
OC   Eukaryota; Sar; Stramenopiles; Bigyra; Opalozoa; Opalinata; Blastocystidae;
OC   Blastocystis.
OX   NCBI_TaxID=12968 {ECO:0000313|EMBL:CBK21621.2};
RN   [1] {ECO:0000313|EMBL:CBK21621.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Singapore isolate B {ECO:0000313|EMBL:CBK21621.2};
RA   Wincker P.;
RT   "Sequencing and annotation of the Blastocystis hominis genome.";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FN668643; CBK21621.2; -; Genomic_DNA.
DR   RefSeq; XP_012895669.1; XM_013040215.1.
DR   AlphaFoldDB; D8M0N2; -.
DR   EnsemblProtists; CBK21621; CBK21621; GSBLH_T00001760001.
DR   GeneID; 24918989; -.
DR   InParanoid; D8M0N2; -.
DR   OrthoDB; 2880475at2759; -.
DR   Proteomes; UP000008312; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR   Gene3D; 1.10.150.80; HRDC domain; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR045092; Rrp6-like.
DR   PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR   PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SUPFAM; SSF47819; HRDC-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008312}.
FT   DOMAIN          417..497
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
SQ   SEQUENCE   500 AA;  57662 MW;  AC0A3ED4310BBD3D CRC64;
     MCNMIKTTCI QSYQELFDLY EPNNGLSLLE IPALESGDEF EVIRQLEDYM FALTDACLNK
     ADSTPASSSD VDNLIKDVQE AIQTPLINYT ITEKPQDRFG DRVDALDLNF APKLREKHNA
     RKEWVYEDIS RIPGIFFQDD YQRELGIDPR TQLISIYRNP YSYEIHNLEF PDWEVRGDLG
     VPPSCSLDDT VVEFIDTEEK IMDLIARLKS FRCISVSVIQ HSYRSYLGYC SMIMISSGEI
     DYAIDAIATH NSCWKLNDLF TNPSIVKVMF NAGDQLLWLQ RDFGVFMVNL FDVQMALKLL
     DEKQTSFSDV LMNRMNEYIN MRFRRADWRT RPLTAGMLRF ARQTAHSTLY LSSMVIEQLQ
     NESEKHINRV GDGRVGDGQI VETLAACNEL CLETYHKPVQ TYETGESTIA ELGQIFQPVQ
     KMLFLSLYYW RDVVARELDE SVQYVLPLLP LLKVAHAVPK TKEELRRLLS PLSATAEQRL
     DRLFSIVESC RSEKLVEKNA
//