ID D8P6B5_RALSL Unreviewed; 649 AA.
AC D8P6B5;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Sensor protein {ECO:0000256|PIRNR:PIRNR003167};
DE EC=2.7.13.3 {ECO:0000256|PIRNR:PIRNR003167};
GN ORFNames=RCFBP_mp30368 {ECO:0000313|EMBL:CBJ54451.1};
OS Ralstonia solanacearum CFBP2957.
OG Plasmid RCFBPv3_mp {ECO:0000313|EMBL:CBJ54451.1}.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Ralstonia.
OX NCBI_TaxID=859656 {ECO:0000313|EMBL:CBJ54451.1};
RN [1] {ECO:0000313|EMBL:CBJ54451.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFBP2957 {ECO:0000313|EMBL:CBJ54451.1};
RC PLASMID=RCFBPv3_mp {ECO:0000313|EMBL:CBJ54451.1};
RX PubMed=20550686; DOI=10.1186/1471-2164-11-379;
RA Remenant B., Coupat-Goutaland B., Guidot A., Cellier G., Wicker E.,
RA Allen C., Fegan M., Pruvost O., Elbaz M., Calteau A., Salvignol G.,
RA Mornico D., Mangenot S., Barbe V., Medigue C., Prior P.;
RT "Genomes of three tomato pathogens within the Ralstonia solanacearum
RT species complex reveal significant evolutionary divergence.";
RL BMC Genomics 11:379-379(2010).
RN [2] {ECO:0000313|EMBL:CBJ54451.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CFBP2957 {ECO:0000313|EMBL:CBJ54451.1};
RC PLASMID=RCFBPv3_mp {ECO:0000313|EMBL:CBJ54451.1};
RA Genoscope - CEA;
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085,
CC ECO:0000256|PIRNR:PIRNR003167};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FP885907; CBJ54451.1; -; Genomic_DNA.
DR RefSeq; WP_013208915.1; NZ_CP115953.1.
DR AlphaFoldDB; D8P6B5; -.
DR PATRIC; fig|859656.5.peg.4790; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046983; F:protein dimerization activity; IEA:UniProtKB-UniRule.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.8.500; HAMP domain in histidine kinase; 1.
DR Gene3D; 1.20.120.960; Histidine kinase NarX, sensor domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR029095; NarX-like_N.
DR InterPro; IPR042295; NarX-like_N_sf.
DR InterPro; IPR016380; Sig_transdc_His_kin_NarX/NarQ.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF66; NITRATE_NITRITE SENSOR PROTEIN NARQ; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR Pfam; PF13675; PilJ; 1.
DR PIRSF; PIRSF003167; STHK_NarX/NarQ; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR003167};
KW Cell inner membrane {ECO:0000256|PIRNR:PIRNR003167};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR003167};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR003167};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR003167};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR003167};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Plasmid {ECO:0000313|EMBL:CBJ54451.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR003167};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012,
KW ECO:0000256|PIRNR:PIRNR003167}.
FT TRANSMEM 23..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 200..252
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 451..645
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 649 AA; 72345 MW; 5C2FF5FC689DA565 CRC64;
MIALSDTFPT RLPPFWRRLS TRIVTVSLDA ATLVLIVIAG TLWLSWQLEG AGAAINDTGS
LRMRASQIGI AVLEARNGRG NTLDTQIAQL DATLAALRHG DAQRPLFLPN DPDIRRQFDV
VMAYWTTQLK PRASTERAQQ TGMPSAYLVY LPGFIKEADQ LVRMIERSNA RKTTLLRSSQ
FVLAAMACIG TLLMIYLLYL WIILPVLRLQ DGLRRMAAHD FATRLNVQTH DEIGQLTQGF
NRMAQELQSL YVDLESRVTQ KTEQLGVHNR ELSALYDITA FLNMAGDIDS MCRGFIQRVT
AQFRAAGGSI RVMDPDGQRL HLVASEGLPA ELADAEHCMP ADACLCGMAM RQDVVLLHDF
RPMPPPVQPE PAYRCERAGY TGVAVFQIKT QQAMLGTFAL HFRSEQQLPA SDVRLLETLG
QHLGIAIDHL RLSAKATQLA VIEERNLFAQ GLHDSIAQGL NFLNLQVQLL DGAVQRQDLN
EAREIVPLLR FGVEESYQDV RELLLNFRTK LEQGTLRPAV EQTLARFARQ TGITPDLRYE
ENGGAPLPAA QQLQVLFILQ EALSNVRKHA VASRVAVSVI NGRDFELHVE DDGRGYDERE
VAERAQAHVG LSIMRERAAY LSAQLRLEGR PGKGTTVILQ LQEQQRQAA
//
