ID D8Q2A4_SCHCM Unreviewed; 1433 AA.
AC D8Q2A4;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=VPS10 domain-containing protein {ECO:0000259|SMART:SM00602};
GN ORFNames=SCHCODRAFT_76333 {ECO:0000313|EMBL:EFI98648.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFI98648.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
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DR EMBL; GL377305; EFI98648.1; -; Genomic_DNA.
DR RefSeq; XP_003033551.1; XM_003033505.1.
DR STRING; 578458.D8Q2A4; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_02620327; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR InParanoid; D8Q2A4; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1433
FT /note="VPS10 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003120515"
FT TRANSMEM 1324..1346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..673
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 699..1321
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 1433 AA; 160302 MW; 7DC8471ED2B21E6C CRC64;
MLWTWLLLAG LAAAAGLPSS QLTSFPNLPS NIFFFDDSTD AVFVDSVDGT VFVSSDEGKT
WADAGIEGVQ TVVEHPFDRN YAFAIGRGTT HYRTADRGRS WQRFSSPAAP ALISKPLAFH
VDQPGHVLFQ VTHCEPRKIG WGVVCRDETY YTTDAFSTEM RFMRADTSRC AFAHSTKEFK
HDAHRDLVFC VAFDADAVAG AHAIESSRLF ASTDFFENDV RIEDLGIGKA AKGVLALAIV
SKFAVVALRD ITHADTRLYV STDAQNWAHA EFPQSSSALL KENAYTIVES TLHSLAVDVV
RGDNDGATGT LFVSNSNGTY FVESLADTNR NSAGYVDYEH IYGVDGVGLA NVVANADQAG
TPGVTKRLRT MITFDDGRRW SPIRAPEGSN CDTRDIENCA LHLHSVTTPH NFGRVFSSPA
PGYVMAVGSV GPALAPYEDS DTYLSSDAGL TWTRIAEGAH KYEFGDAGSL LVLIDDEEAT
SEVKWSGDGG RTWETYDFGQ RLRARALVTV PDSTSRKFLV LGEDQSDKKV GPYVVQWLDF
ADTRDRKCGD NDFEKWYARS GETECLLGHK QWYRRRKPNA DCYVGEKFNE PVEHDEPCEC
GESDYECDYN FVRQGADCVP VGPEPVPAGT CTTGRPDETY RGSSGYRKIP GDICEGGIAK
DAPVEKQCSQ AEPAEGAVVH QTFEFPAVVA QHAYFKDSPT ILVRLTDHTI WQSANEGYTW
TQLFPEERFL GFYHHKYTGD RAYLVTPNAR FYYTTDAGRN WYPQEAPNPP NTFRAQVLRF
HPTSDYLIWV GNKDCEGQGE KCRAVASYSR DNGRRWTTID EYVQNCAWAR DARLAADPNE
ILCESFRDKK GSQRMFGGEN PLELVVGGNY YTKKRRMFEH VVGFAKFSEY LVVAAMDPKS
RSLQLQVSLD GANFAEGRFP PSMHPETHAY TVLESSTNSL FLHMTMSEPP SPYWGNILKS
NSNGTYFGVS AEHVNRDERG YVDFEKASCR RTLRAVLTGH KALQSRITHN DGGTWKPLNP
PPVDSFGNKY ECQSTNCALH IHGYTERLDP RATYSSPSIV GLLMAVGNVG EHLLPYTESD
TFLSRDAGFT WEEVHKDAHL WEFGDSGSVL VMANDEEPTD HVLFSTNEGK SWREYKFVEG
GKLRVRQIVT VPSDTSRRFI LIAHGPRETN SYAIHLDFSA LTKKQCVLSI EDPGHDDFEL
WSPSEERTER CLFGRQTLYH RRVRDTNCVV GKQPKAEERV QKNCLCTASD FECEFNYMRN
DAGECVLVPG TQPLPDDDSV CRAGDEYWYE RTAYRKIPYS SCEGGERPDR GLRHICPGFR
AHGALFWMSI IVLPFAFTAL IAYWFYKRSG MMRGTIRLPG DGRGLSAPSF GNDSSVLDTL
ASVPWFIIGI TGIAYEWAAS RVEGFFDGYR SRRGYRNVPI DEDAQILRFE DED
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