ID SEC11_SCHCM Reviewed; 193 AA.
AC D8Q7Q5;
DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 06-MAR-2013, entry version 18.
DE RecName: Full=Signal peptidase complex catalytic subunit SEC11;
DE EC=3.4.21.89;
DE AltName: Full=Signal peptidase I;
GN Name=SEC11; ORFNames=SCHCODRAFT_56459;
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC Agaricomycetes; Agaricomycetidae; Agaricales; Schizophyllaceae;
OC Schizophyllum.
OX NCBI_TaxID=578458;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210;
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E.,
RA Stajich J.E., de Vries R.P., Record E., Levasseur A., Baker S.E.,
RA Bartholomew K.A., Coutinho P.M., Erdmann S., Fowler T.J.,
RA Gathman A.C., Lombard V., Henrissat B., Knabe N., Kuees U.,
RA Lilly W.W., Lindquist E., Lucas S., Magnuson J.K., Piumi F.,
RA Raudaskoski M., Salamov A., Schmutz J., Schwarze F.W.M.R.,
RA vanKuyk P.A., Horton J.S., Grigoriev I.V., Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
CC -!- FUNCTION: Catalytic component of the signal peptidase complex
CC (SPC), which catalyzes the cleavage of N-terminal signal sequences
CC of proteins targeted to the endoplasmic reticulum. Signal peptide
CC cleavage occurs during the translocation (cotranslationally or
CC post-translationally) through the translocon pore into the
CC endoplasmic reticulum (By similarity).
CC -!- CATALYTIC ACTIVITY: Cleavage of hydrophobic, N-terminal signal or
CC leader sequences from secreted and periplasmic proteins.
CC -!- SUBUNIT: Component of the signal peptidase complex (SPC) (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC type II membrane protein (By similarity).
CC -!- SIMILARITY: Belongs to the peptidase S26B family.
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DR EMBL; GL377307; EFI96467.1; -; Genomic_DNA.
DR RefSeq; XP_003031370.1; XM_003031324.1.
DR MEROPS; S26.010; -.
DR GeneID; 9586711; -.
DR KEGG; scm:SCHCODRAFT_56459; -.
DR KO; K13280; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR InterPro; IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
DR InterPro; IPR019759; Peptidase_S24_S26.
DR InterPro; IPR015927; Peptidase_S24_S26A/B/C.
DR InterPro; IPR001733; Peptidase_S26B.
DR PANTHER; PTHR10806; PTHR10806; 1.
DR Pfam; PF00717; Peptidase_S24; 1.
DR PRINTS; PR00728; SIGNALPTASE.
DR SUPFAM; SSF51306; Pept_S24_S26_C; 1.
DR TIGRFAMs; TIGR02228; sigpep_I_arch; 1.
DR PROSITE; PS00501; SPASE_I_1; 1.
DR PROSITE; PS00761; SPASE_I_3; 1.
PE 3: Inferred from homology;
KW Complete proteome; Endoplasmic reticulum; Glycoprotein; Hydrolase;
KW Membrane; Protease; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1 193 Signal peptidase complex catalytic
FT subunit SEC11.
FT /FTId=PRO_0000412364.
FT TOPO_DOM 1 16 Cytoplasmic (Potential).
FT TRANSMEM 17 41 Helical; Signal-anchor for type II
FT membrane protein; (Potential).
FT TOPO_DOM 42 193 Lumenal (Potential).
FT ACT_SITE 55 55 By similarity.
FT CARBOHYD 106 106 N-linked (GlcNAc...) (Potential).
SQ SEQUENCE 193 AA; 21588 MW; 886B716D535F6BCB CRC64;
MFSEELKAFR RLGIRHLLLQ ALNFASVIAS GLMMWKGLGV ITNTESPIVV VLSGSMEPAF
YRGDLLFLTN PSGVRFHTGD ITVYKVPNGD IPIVHRVLET HEIAPNATFV PHKYNRAYTP
EDQLLLTKGD NNPIDDTGLY TQGMDWLERK HIVGKVRGFV PYVGYATIAM NDFPQLKYGL
LGILGLMALI QRE
//
