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Database: UniProt
Entry: D8Q7Q5
LinkDB: D8Q7Q5
Original site: D8Q7Q5 
ID   SEC11_SCHCM             Reviewed;         193 AA.
AC   D8Q7Q5;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   01-OCT-2014, entry version 23.
DE   RecName: Full=Signal peptidase complex catalytic subunit SEC11;
DE            EC=3.4.21.89;
DE   AltName: Full=Signal peptidase I;
GN   Name=SEC11; ORFNames=SCHCODRAFT_56459;
OS   Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Agaricomycetes; Agaricomycetidae; Agaricales; Schizophyllaceae;
OC   Schizophyllum.
OX   NCBI_TaxID=578458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H4-8 / FGSC 9210;
RX   PubMed=20622885; DOI=10.1038/nbt.1643;
RA   Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E.,
RA   Stajich J.E., de Vries R.P., Record E., Levasseur A., Baker S.E.,
RA   Bartholomew K.A., Coutinho P.M., Erdmann S., Fowler T.J.,
RA   Gathman A.C., Lombard V., Henrissat B., Knabe N., Kuees U.,
RA   Lilly W.W., Lindquist E., Lucas S., Magnuson J.K., Piumi F.,
RA   Raudaskoski M., Salamov A., Schmutz J., Schwarze F.W.M.R.,
RA   vanKuyk P.A., Horton J.S., Grigoriev I.V., Woesten H.A.B.;
RT   "Genome sequence of the model mushroom Schizophyllum commune.";
RL   Nat. Biotechnol. 28:957-963(2010).
CC   -!- FUNCTION: Catalytic component of the signal peptidase complex
CC       (SPC), which catalyzes the cleavage of N-terminal signal sequences
CC       of proteins targeted to the endoplasmic reticulum. Signal peptide
CC       cleavage occurs during the translocation (cotranslationally or
CC       post-translationally) through the translocon pore into the
CC       endoplasmic reticulum (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: Cleavage of hydrophobic, N-terminal signal or
CC       leader sequences from secreted and periplasmic proteins.
CC   -!- SUBUNIT: Component of the signal peptidase complex (SPC).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S26B family. {ECO:0000305}.
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DR   EMBL; GL377307; EFI96467.1; -; Genomic_DNA.
DR   RefSeq; XP_003031370.1; XM_003031324.1.
DR   MEROPS; S26.010; -.
DR   GeneID; 9586711; -.
DR   KEGG; scm:SCHCODRAFT_56459; -.
DR   KO; K13280; -.
DR   OrthoDB; EOG7BCNQ4; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR   InterPro; IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
DR   InterPro; IPR019759; Peptidase_S24_S26.
DR   InterPro; IPR015927; Peptidase_S24_S26A/B/C.
DR   InterPro; IPR001733; Peptidase_S26B.
DR   PANTHER; PTHR10806; PTHR10806; 1.
DR   Pfam; PF00717; Peptidase_S24; 1.
DR   PRINTS; PR00728; SIGNALPTASE.
DR   SUPFAM; SSF51306; SSF51306; 1.
DR   TIGRFAMs; TIGR02228; sigpep_I_arch; 1.
DR   PROSITE; PS00501; SPASE_I_1; 1.
DR   PROSITE; PS00761; SPASE_I_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Endoplasmic reticulum; Glycoprotein; Hydrolase;
KW   Membrane; Protease; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    193       Signal peptidase complex catalytic
FT                                subunit SEC11.
FT                                /FTId=PRO_0000412364.
FT   TOPO_DOM      1     16       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     17     41       Helical; Signal-anchor for type II
FT                                membrane protein. {ECO:0000255}.
FT   TOPO_DOM     42    193       Lumenal. {ECO:0000255}.
FT   ACT_SITE     55     55       {ECO:0000250}.
FT   CARBOHYD    106    106       N-linked (GlcNAc...). {ECO:0000255}.
SQ   SEQUENCE   193 AA;  21588 MW;  886B716D535F6BCB CRC64;
     MFSEELKAFR RLGIRHLLLQ ALNFASVIAS GLMMWKGLGV ITNTESPIVV VLSGSMEPAF
     YRGDLLFLTN PSGVRFHTGD ITVYKVPNGD IPIVHRVLET HEIAPNATFV PHKYNRAYTP
     EDQLLLTKGD NNPIDDTGLY TQGMDWLERK HIVGKVRGFV PYVGYATIAM NDFPQLKYGL
     LGILGLMALI QRE
//
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