ID D8QED1_SCHCM Unreviewed; 325 AA.
AC D8QED1;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=SAM-dependent methyltransferase Erg6/SMT-type domain-containing protein {ECO:0000259|PROSITE:PS51685};
GN ORFNames=SCHCODRAFT_258271 {ECO:0000313|EMBL:EFI93830.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFI93830.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Erg6/SMT family. {ECO:0000256|ARBA:ARBA00038188,
CC ECO:0000256|PROSITE-ProRule:PRU01022}.
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DR EMBL; GL377310; EFI93830.1; -; Genomic_DNA.
DR RefSeq; XP_003028733.1; XM_003028687.1.
DR AlphaFoldDB; D8QED1; -.
DR STRING; 578458.D8QED1; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_02680330; -.
DR eggNOG; KOG1269; Eukaryota.
DR HOGENOM; CLU_039068_5_0_1; -.
DR InParanoid; D8QED1; -.
DR OMA; AFNKAMH; -.
DR OrthoDB; 275921at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901617; P:organic hydroxy compound biosynthetic process; IEA:UniProt.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR030384; MeTrfase_SMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR013705; Sterol_MeTrfase_C.
DR PANTHER; PTHR44068:SF1; HYPOTHETICAL LOC100005854; 1.
DR PANTHER; PTHR44068; ZGC:194242; 1.
DR Pfam; PF13847; Methyltransf_31; 1.
DR Pfam; PF08498; Sterol_MT_C; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51685; SAM_MT_ERG6_SMT; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01022};
KW Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01022};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01022}.
FT DOMAIN 26..323
FT /note="SAM-dependent methyltransferase Erg6/SMT-type"
FT /evidence="ECO:0000259|PROSITE:PS51685"
SQ SEQUENCE 325 AA; 36499 MW; 36ED3E9E04A56EE3 CRC64;
MAVNWIGETA DHETGETGRT WGWRRALRLC PPLYEYGWGR SFHFSRFYKG ESIAASLARH
EHYLAAQMNL RPKMRVLDIG CGVGGPAREI ARFADVEIIG LNNNDFQVAR ARQYTKEAGL
ENQVKFVKGD FMKLAEQFGE NAFDAVYAVE ATCHAPSFAG VYGEVFKVLK PGGVFGCYEW
VMTDAWDASN PAHKALAHQV ELGNGIPEMR PLHMARDAVK EVGFELEHEE DLAERDDPVP
WYYPLEGDIS KAQTLWDLFV VWRISPTGKF VTHYGLKIIE MLGMVPKGTH DVGEQLKVAQ
DALVKGGQTK LFTPMYLMIA RKPSA
//
