ID D8SPP7_SELML Unreviewed; 3461 AA.
AC D8SPP7;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Dynein heavy chain {ECO:0000313|EMBL:EFJ13707.1};
DE Flags: Fragment;
GN Name=DHC2-2 {ECO:0000313|EMBL:EFJ13707.1};
GN ORFNames=SELMODRAFT_449697 {ECO:0000313|EMBL:EFJ13707.1};
OS Selaginella moellendorffii (Spikemoss).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Lycopodiopsida; Selaginellales; Selaginellaceae; Selaginella.
OX NCBI_TaxID=88036 {ECO:0000313|Proteomes:UP000001514};
RN [1] {ECO:0000313|EMBL:EFJ13707.1, ECO:0000313|Proteomes:UP000001514}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551031; DOI=10.1126/science.1203810;
RA Banks J.A., Nishiyama T., Hasebe M., Bowman J.L., Gribskov M.,
RA dePamphilis C., Albert V.A., Aono N., Aoyama T., Ambrose B.A., Ashton N.W.,
RA Axtell M.J., Barker E., Barker M.S., Bennetzen J.L., Bonawitz N.D.,
RA Chapple C., Cheng C., Correa L.G., Dacre M., DeBarry J., Dreyer I.,
RA Elias M., Engstrom E.M., Estelle M., Feng L., Finet C., Floyd S.K.,
RA Frommer W.B., Fujita T., Gramzow L., Gutensohn M., Harholt J., Hattori M.,
RA Heyl A., Hirai T., Hiwatashi Y., Ishikawa M., Iwata M., Karol K.G.,
RA Koehler B., Kolukisaoglu U., Kubo M., Kurata T., Lalonde S., Li K., Li Y.,
RA Litt A., Lyons E., Manning G., Maruyama T., Michael T.P., Mikami K.,
RA Miyazaki S., Morinaga S., Murata T., Mueller-Roeber B., Nelson D.R.,
RA Obara M., Oguri Y., Olmstead R.G., Onodera N., Petersen B.L., Pils B.,
RA Prigge M., Rensing S.A., Riano-Pachon D.M., Roberts A.W., Sato Y.,
RA Scheller H.V., Schulz B., Schulz C., Shakirov E.V., Shibagaki N.,
RA Shinohara N., Shippen D.E., Soerensen I., Sotooka R., Sugimoto N.,
RA Sugita M., Sumikawa N., Tanurdzic M., Theissen G., Ulvskov P., Wakazuki S.,
RA Weng J.K., Willats W.W., Wipf D., Wolf P.G., Yang L., Zimmer A.D., Zhu Q.,
RA Mitros T., Hellsten U., Loque D., Otillar R., Salamov A., Schmutz J.,
RA Shapiro H., Lindquist E., Lucas S., Rokhsar D., Grigoriev I.V.;
RT "The Selaginella genome identifies genetic changes associated with the
RT evolution of vascular plants.";
RL Science 332:960-963(2011).
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000256|ARBA:ARBA00004611}.
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DR EMBL; GL377631; EFJ13707.1; -; Genomic_DNA.
DR RefSeq; XP_002985213.1; XM_002985167.1.
DR STRING; 88036.D8SPP7; -.
DR EnsemblPlants; EFJ13707; EFJ13707; SELMODRAFT_449697.
DR Gramene; EFJ13707; EFJ13707; SELMODRAFT_449697.
DR KEGG; smo:SELMODRAFT_449697; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_0_0_1; -.
DR InParanoid; D8SPP7; -.
DR OMA; GRDIPCS; -.
DR Proteomes; UP000001514; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001514}.
FT DOMAIN 199..597
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 726..1052
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1218..1361
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 1582..1680
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 1744..2004
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2018..2361
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2391..2612
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 2857..2970
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3005..3145
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3152..3457
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 2261..2309
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFJ13707.1"
SQ SEQUENCE 3461 AA; 391489 MW; 56D1DD1EDBB5CCA2 CRC64;
IGVLHIDSKS LRNSLLPVTT RTLDAIKGLL LIAAREETIK VLAHFQEKVK ALEVRPTMEK
KKASLAEATI VDEMYSLLAG YEVKVPTDDQ IKLDDLHEIV QKYGDSIEAA TIYIEENRTD
MMADLDSKAN SLNEELVAIL GMLHQERFLR SESDPFEIVT EMEQIWDRMV EIRDTLEIYK
DYQKLFQMDM EDMSNFLMTE KEYNLRYGVW KALRDWLVMV KQWREGPVAS LKAPEVQGKT
DEYAKEAYKM GKANKEDTVV FRLKDAIDDF KQLLPLIEEL ANPALKDRHW TQIFKQVGQE
YKDGLVFSIN DMLDYKIMDK IEEVRVIGGV ASKEFSFQRT LDKMEKDWEG VEFIVLPYKD
SGTFILGGLD DIQTILDDQL VKIMSMCASP FIKIFEGRAV RWKTLMINMQ DLLDNWVECQ
ATWQYLGPIF GSKDIMRQMP EEGEKFQTVD ATWRDVMKRT VATPGCIETA VDVERLEKLK
EANRLLEIIN KGLASYLEVK RVAFPRFFFL SNDEMLEILS ETKDPLRVQP HLKKCFEGID
TLRFEHNMDV TGMISAEGEV VPLVEKFNPK AAQGAVEKWL LQVEEGMLQS LQEQCSSSVI
AYAETVREKW VLEWPGQIVL VVSAIYWTTM VTESILAGGN AVRECEKACT EQLGRIVNLV
RGNLTRLNRA TLSALVVMDV HARDVVTILA NAKVEKETDF LWQSQLRIYW EKDTCFVRMM
NAGVEYGYEY LGNSSRLVIT PLTDRCYRTL MGAIHLNMGG APEGPAGTGK TETTKDLAKA
LARQCVVFNC SDSLDYLAMA KFFKGLAAAG AWACFDEFNR IDLEVLSVVA QQVLEVQLAV
QNKVKTFVFE GTELTLKPTC NVFITMNPGY AGRSELPDNL KALFRTVAMM VPDYAMISEI
MLYSSGYLLA RDCARKIVAT YRLCSEQLSS QDHYDYGMRA VMAVLRAASN LKQRYPDEEE
FILMLRSIID VNLCKFLSQD VPLFNGIVSD LFPGVVLPEP DYTNLDKVIR DNCKKFNLQP
TPYFKIKIIQ LYEMIIVRHG LMLVGLSFSG KTCALRVLQA ALTDLAEQGL DNERRVQIAT
VNPKSVTMGQ LYGQADPMTQ EWLDGVLAVR FREQASDPSN DRKWLVLDGP VDAIWIENMN
TVLDDNKKLC LPNSEIIQMS SSMNMIFEVG DLAVASPATV SRCGMVYLEP HQMGWQPLML
SWLDTLPASL QGPLRTHLQG LFEWMVTACL RFVRKSVKEL SPTSDANIVV SLMRNFYGLI
DELKPEEAGK AFGKEKLGIW VDSIFLFSLV WSIGATGDNE ARQGFDAFLR HLAAGEVPEG
YELWVPSTHV DLFTKIMPDD DGATVYDFLF DKENAAWLLW TATIVPLEIP QGAIFSEIII
PTKDMVRYTF LLDKGIQANY PVLLVGSTGT GKSVYINRHL SLGLPKEFFT TIFVCFSART
SANMTQNQID GQLDRRKRGI YGPVLGKRCI IFVDDLNMPQ PEVYGAQPPI ELLRQYMDHD
GWYGRDNVFK KIVDVLFVAG MGPPGGGRNF VTQRFLRHFN VVGVAQVAED SLRLIFNTIL
NWHLTINNEF PKDVIYLQPA VINATMDVFN ESKAQLLPTP TKSHYTFNLR DYAKVIQGMM
LQDSSKVPVG REGARQHVRL WVHEVLRVFY DRLVDDQDRD WLLKYLKELV QTRFKQQFDE
LFGHLLGENE LEIGQNEMRR CFFGVYMNED VESRVYEEIT DVPEIISLME NYLTDYNGVS
KRPMNLAIFL FAVEHVSRIC RVLRQPGGHM LLVGVGGSGR QSLTRLGASV SAMEVFQVEI
SKSYTKVEWR EDLISFLKKA GAAPGLPSVF LFSDTQITDE GFVEDLNNLL NSGEVPNMFP
SDEKAQVLEA TKEKAAKLGK ELDSPMEQWR YFVEQCRQKL HVIFCMSPVG QAFRDRLRQF
PSLVNCCTID WFQEWPVDAL EAVAYKFLKD MPLEDKARAS IVKICKAFHE NVREYSLQYK
LKQGRHNYVT PTSYLELIST FQTLLQTKQE EKLKQKRRYE VGLEKLQSSA EQVAVMQQEL
QDLMPKLIVT VKEVEKLMAK VEREKKEVVE PKKAIVMKDE AEASKQAAEA KGIKDECEAV
LAVAMPVLEE ALAALDTLSA NDINYVKKLS NPPAAVKLVM EAVCVILDVK PAKIPDGKGG
TLMDYWKPSV VLLNNKDFLQ NLKDYDKDNI EAKIIAKIRS QYTSNPEFTP AKAANASAAA
EGLCKWIIAM DKYDTVAKFV APKKAKLREA EGKYEVVMVG LRAKQTELKG LLDKLGQLEE
ELDANMLKKE NLQHEVKMCT VKLERAEQLI GGLGGEKTRW IAAAKQLGIE YVNLTGDVLV
ASGIIAYLGA FTAGYRIEIV DLWTKLVRSE NIPRSTSFSF FDILGNPVHV REWMIAGLPN
DSFSIENGII VANSRRWPLM IDPQGQANKW IRNMERERNL QIIKLLGGGD YMRILENAIQ
FGLPVLLENV GEELDPSLEP LLLRQIFKSG GMMCIKLGDT VIEYNNDFRF YITTKYRNPH
YLPETAVKVT LLNFMITKDG LSDQLLGVVV AKERPDLEQQ KNELVVQGAE NKRRLKELED
KILEVLSSSE GNILEDETAV KIISEAKVVG NDITVKQTLA EQTEKNIDEA RKGYQSCGEY
AAILFFCITD LANIDPMYQY SLPWFSSLFV ISIASSEKNP DLIKRLEIIQ DFFLYVLYNN
VCRSLFEKDK LLFSCLLASR ILEMKGEISV PEWMFFLTGG VASSPDRPNP APEWLLDKAW
GELCRVSKFP AFADLSDHVI ANTAAWKAMF SSPEPHMERI PGKYNDVTSF QKLLVLRCIR
PDKVIPGIQR FVTEKLGEEF VQPPQFNLAS CYKDSSATCP LIFVLSPGSD PTAALLKFAG
DMEMGDRLAP ISLGQGQGPK AATMITDAMA TAGSWVLLQN CHLAPSWMPE LERICENVPA
EVHQDFRLWM TSYPSPKFPI TVLQNGVKMT NEPPKGLRAN MRRSYGLDPI SNEEFFESSN
QPEVFKGLLF GLAFFHAVVQ ERRNFGPLGW NIPYGFDDGD LRISVRQLHM FINESTPGQL
PLEALRYVTG ECNYGGRVTD DKDRLLLNTI LRTVYCPEMP QPGYKLSESG IYQTPEPGNW
ESYAKTIDTF PIIPGPEVFG LHTNADITKD MNATALILSS LLATSAAMVS AGGGGGGGGG
GGGEGGVAVV VREILRILSP NFDIEACERK YPVLYEESMN TVLSQEMTRF NKLLDRIRGS
LINMEKAIRG VVVMSAELET AYKSMMINQV PALWQKVSYP SLKPLSSYIT DLMERLHYLQ
DWYDHGVPAV HWVSGFFFAQ SFLTAAMQNY ARKHRYAIDT LGFDYFVVDG EPTQAPREGV
YIKGLYLEGC AWDPVNKCLC ESQPKVIFVP APIIWLKPVL QSDMRDFNHY NCPVYRTMER
RGVLATTGHS TNFLMYLKMP SKEPADHWIR RGVAMLCSLS D
//
