ID D8TK81_VOLCA Unreviewed; 657 AA.
AC D8TK81;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 13-SEP-2023, entry version 37.
DE RecName: Full=CNNM transmembrane domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=VOLCADRAFT_103216 {ECO:0000313|EMBL:EFJ52015.1};
OS Volvox carteri f. nagariensis.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Volvocaceae; Volvox.
OX NCBI_TaxID=3068 {ECO:0000313|Proteomes:UP000001058};
RN [1] {ECO:0000313|EMBL:EFJ52015.1, ECO:0000313|Proteomes:UP000001058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=f. Nagariensis / Eve {ECO:0000313|Proteomes:UP000001058};
RX PubMed=20616280; DOI=10.1126/science.1188800;
RA Prochnik S.E., Umen J., Nedelcu A.M., Hallmann A., Miller S.M., Nishii I.,
RA Ferris P., Kuo A., Mitros T., Fritz-Laylin L.K., Hellsten U., Chapman J.,
RA Simakov O., Rensing S.A., Terry A., Pangilinan J., Kapitonov V., Jurka J.,
RA Salamov A., Shapiro H., Schmutz J., Grimwood J., Lindquist E., Lucas S.,
RA Grigoriev I.V., Schmitt R., Kirk D., Rokhsar D.S.;
RT "Genomic analysis of organismal complexity in the multicellular green alga
RT Volvox carteri.";
RL Science 329:223-226(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GL378325; EFJ52015.1; -; Genomic_DNA.
DR RefSeq; XP_002946789.1; XM_002946743.1.
DR AlphaFoldDB; D8TK81; -.
DR STRING; 3068.D8TK81; -.
DR GeneID; 9624672; -.
DR KEGG; vcn:VOLCADRAFT_103216; -.
DR eggNOG; KOG2118; Eukaryota.
DR InParanoid; D8TK81; -.
DR OrthoDB; 248389at2759; -.
DR Proteomes; UP000001058; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF97; METAL TRANSPORTER CNNM-5; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000001058};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 57..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..235
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 254..316
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 421..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 657 AA; 71277 MW; 09CE4C821C176CEB CRC64;
MWKAGNQKML CNSADLQHCG HGIQGFTQLR SAPLYETVVQ INRRLLGWSD NEAYVDWLYV
VICLLLTCMA GLMSGLTLGL LSLDTVDLEV LLRSGTAREK RCARKIMPII SNNHLLLVTL
LMCNAVAMEA LPLFLDKLAD PVTAVIVSVT AVLFFGEIIP QSVCSRYGLA IGASLAPLVR
LLMWVCSPVA WPMGKLLDLL IGPDHHTLFR RRQLKELVSM HAEDAGMGGA LGRDEIKVIT
GALDLTSKVA FRAMTPLDKV FMLSHVDLLD EVTLRSILRS GHSRIPVHRA GDRREVVGLV
LVKELLQYRL GSSTDVPVAM LRIRSIPRLP ATTRMYDMLR LFQTGRSHMA VLTQPPRGEL
QRLLQLDPSL GKGDVDGFLP YSLYDTAGGN IENSYPPSAL DTQESFDFGV GAVPYDAPTA
SFRHWGTPLE TPRGEYDEAN SSNRMASPAS TTGEAAELSP QQPRQPQPSQ RMNSLFAAAP
AAAVIVAEAA EAEASARTLE AATLTGGTTP GACAATVSSA AVACWPSDSG RLPADHKGTA
SCDAGGGERQ CTTGRDGADA DAEYDMDEVE EGRPIGIITI EDVIEELIRA EIVDETDRYI
DNNRLIRANQ AQLAQSLPEH LAKVPHLLKP NYPNREKYDN TSITTTNTNG NGTSCLL
//
