ID D8TQT5_VOLCA Unreviewed; 3435 AA.
AC D8TQT5;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=PAS domain-containing protein {ECO:0000259|PROSITE:PS50112};
GN ORFNames=VOLCADRAFT_104036 {ECO:0000313|EMBL:EFJ50088.1};
OS Volvox carteri f. nagariensis.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Volvocaceae; Volvox.
OX NCBI_TaxID=3068 {ECO:0000313|Proteomes:UP000001058};
RN [1] {ECO:0000313|EMBL:EFJ50088.1, ECO:0000313|Proteomes:UP000001058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=f. Nagariensis / Eve {ECO:0000313|Proteomes:UP000001058};
RX PubMed=20616280; DOI=10.1126/science.1188800;
RA Prochnik S.E., Umen J., Nedelcu A.M., Hallmann A., Miller S.M., Nishii I.,
RA Ferris P., Kuo A., Mitros T., Fritz-Laylin L.K., Hellsten U., Chapman J.,
RA Simakov O., Rensing S.A., Terry A., Pangilinan J., Kapitonov V., Jurka J.,
RA Salamov A., Shapiro H., Schmutz J., Grimwood J., Lindquist E., Lucas S.,
RA Grigoriev I.V., Schmitt R., Kirk D., Rokhsar D.S.;
RT "Genomic analysis of organismal complexity in the multicellular green alga
RT Volvox carteri.";
RL Science 329:223-226(2010).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR EMBL; GL378332; EFJ50088.1; -; Genomic_DNA.
DR RefSeq; XP_002948708.1; XM_002948662.1.
DR GeneID; 9623413; -.
DR KEGG; vcn:VOLCADRAFT_104036; -.
DR eggNOG; KOG1153; Eukaryota.
DR InParanoid; D8TQT5; -.
DR OrthoDB; 316474at2759; -.
DR Proteomes; UP000001058; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR CDD; cd00130; PAS; 1.
DR CDD; cd04077; Peptidases_S8_PCSK9_ProteinaseK_like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 2.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR31600; TINY MACROCYSTS PROTEIN B-RELATED; 1.
DR PANTHER; PTHR31600:SF2; TINY MACROCYSTS PROTEIN B-RELATED; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS50112; PAS; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Chromophore {ECO:0000256|ARBA:ARBA00022543};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Photoreceptor protein {ECO:0000256|ARBA:ARBA00022543};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Receptor {ECO:0000256|ARBA:ARBA00022543};
KW Reference proteome {ECO:0000313|Proteomes:UP000001058};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..3435
FT /note="PAS domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003123773"
FT TRANSMEM 821..840
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 879..904
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 932..954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 966..986
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 998..1015
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1144..1166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1178..1203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2600..2621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3097..3117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3332..3353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1450..1503
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 1790..1831
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1860..1882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2149..2256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2369..2419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2465..2565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2873..2991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3013..3077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3391..3413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2213..2256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2541..2565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2877..2892
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 189
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 249
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 464
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 3435 AA; 367351 MW; BB2A1209E6BAAFD4 CRC64;
MGASRCPAQG FSLGSACLAS MLLALTALSS PSPSQPADAT APNENWILVL KSNVDPDAFT
ATLCAESNLL RKQHRYSCTD TFRTLIRGIS GRFSRAAIRD VQQLYKESVD HATRDRGFSI
GDQLLTACEE ADQQQGTSNS TARSTARRLP EQLDPVTWGL DRIDQSSLPL DSVYHYDSVG
TGVHVYVLDS GIRASHVQFR IMGPASAEQQ GKSNIIYHTP TINALNGTRV TSGFAAVGDS
LPTEDCFGHG THVAAIIGGL DNGVAKNVTL HPVKVLDCYG NANETSLLQG LEWVARNLEY
PAVVHMSLEG YYSSPVNAAI DALVRSRPFP LRELRVIQTP YVTHNAPINQ THVKRLYDRV
GAHGSPRSSA LITHPTLSRG AMAHPDGRMG VVVVASAGNG NVDACNVSPA SAQSAIAVGA
IDTDGRRWYK SNWGPCLDLF APGVNVISAV PWTDASEAPK TGTSMAAPFV TGVAALYLDN
HPGASPADVA QRLLRSSLAG VVTDDRLGSD TFTPSPSTSA WAPLDISSTP NRLLQSVLIV
PVRVSPGIVI VAPLSEPLPG STAIGNVDIE VSLQLQPTGQ VNMTASAPLA WNGEPLANVF
PSSLTFTLSN YNQSQRLLLQ PNAATAQGAY YVQLSMRSTD PRFDFAAQVL KVNDTREQVG
ETTAVPRLIR ALPFNDSGNT ILFRHDYTTS PGNSLDVSPD VAYAYTAPFA QTITVSTCGS
AYDTVLLLGQ RDDMQLESTL ANDDDPACGA ASRIDKDILA GVTYYIVVSG FNGDAGEFVL
SVRTTAAERE EGDLLEQKRS IQDGIFSCMY TLVRQAALSG WKFAVLKVVL EGLMGFIVVF
NPSITAWNID VNNPVWQLVR WAVWRSPIVR LYGYKTYIIV MYVMVAIVIM AVLGLVSFFD
YFVFAANCNF TKKEKNHVYF GSSVNCLAMP HIAHMTVALF TAAVFFGVTA LMVVASSDLN
PVSRAYLASP VAVARLQILA AKAAYVIVAN DFQSWPKPQA ICIVLCAGLI CWWNFRRPAA
IIHRPSGLGA AGGSQRVNSC RPPLCCARAV TPVSLDGIEI HRAQESGQSP LYSRPLPTVA
WAGACCRPVS PLLLGECCSR GWLGHQERFP FQGGLPDRLK GALLVARLRW LPVFKREFSR
KAAIAVWCSL WFGILYVAVL LAYLAFGDNH SAHHRRHVTL LVLYGIFPTV AVGWVACTVH
AWWAAWPARK FKGLAPGMRL AKVHKFHSVQ EVELLSRVMR RFTIDGTIDE GAAALGETII
KAGMQAFPNS PFLLILYANF LLEVRKDGPA SRTQLQQASR HTPTLVERYQ IFCTGEASKR
LKDSQDCGMD LQAYIEFRRN FRAVLRVHKE VLMLQAELWM LMLKTCLRVV EVDRALNALE
SGTERAHQVY RRVLERYPTN GKLLRCYGKF LEDVKHDPVA ASKAYNEASR NGGGDAILNL
DLSNIQGSSS KPEFLTSMSM EDDAVVVINA EGTIMMVSQA VQQVFGYPKS ELEGANVNLL
MPQPFSQRHS GYLARYSGGG EPHILDTERY VFPMALCVTR MSGAGADSIF LGVARPLPTN
SLTVRAWIAP NGVVLCGDQQ FASLCGISEG DLVGRPLSNL VCDDEGEVER LMARCKEAAP
EEFLARSITL KLLFKHRYLD PVPVDVTVGL AGTEAQRILV LNCNRTDGRE GTLIVVDSHM
RMRFASCGVS TLLGYPMRKL ATMRLDQLLP PPYNTLHSKF LRVGHGRVGV GVGDEVGEGQ
AVHMLNENGS LVAVRLKISV AMATDTASTL YVVQIEKRPA DEAMAEKQLV VTADFGGRVL
LVSQPSSELF GFRSADMIGC NLCDIIDIFQ EWRDQAGESQ MQLLMLALLD KEHEMPGTSW
RVRVHPPISE TTSHPLLQRN RSSIKRPSAL KGAAAPSAGS KSACLQVELH DELYEQEADG
GGGDEDAAVG KEGSATASRD VYGARIRVTL WRRDLLSGVV ELDDELVIRR ASPMTGLIVG
MPSTAMLRKP LQRFLDIPAD TSWQKLSDEH SKHKKQRSAL KSSGSCAVIS PVMTFIGPHP
DTGTMRIVVQ GVQVLAPGGR SKVVVTLHPD TTYAGAHADL MRVLHLDAAL FLAKSARQQI
SQQANRPGGG GGGGKVVALG ETGDDGGCGD GGKHVKVLLD AKAGSVARRG TAATGGQPPP
AAAMEGAARA DGGPERQLEA AEEGGAVAAQ SGVGEGEGLG DGEGEGEGND DGDGDGDRSN
GDGDGDGEGK TSSDSSSDSG GRRRRRSSDG SRDLDAEGQA KILSRAAAWR RNRLMGLMEL
EVLDVSSFQM LNLCQRPRLH QSIWLRLLPF SLKHSLASKS EFVAQWVRTI TRRRSGPHDA
QLPISERPST AAATAAATAA GSAAAAAVGG AGSHPAADNT SAAGAAAAGP FPAATSKTGS
GGGGGGGGFP SLGALLGPER KPSTMLASIP EHKSTTGGGG LLDTAQSRRR AAESFAFTRV
LSGRGGASTV DDLEPWSGGP ALVGSRQSFD GSPPGGLDGN AAGGDGGRID GGGGGGGGSE
DAGGGGGRGG GEKWEKGSEG GESSTEGSQA ASGITSSTDA QSANEPIIDS RRWKLLKALT
KQLAGPNLMT PMERLRLHSY ILLAVMLTTH IVAYIVVTLL IKEQHHDVNL VHRQALAMDR
SQLIAVRAMM GAYCERDNVT AKVSVCANRQ VGGVWEAVPG RKGKGLNFTL YKLRENVNLM
EKHHQFVFLG ESRTAVIKLM PEVYDIWTSQ QLEYHSYMDT ATPRILTGAT GAWVLGNRYI
AAAREALYWL RTIRDNYRLH RTYQFLVDNG LGPLFTVYAK SLDLLVDAAW KAVDQLRIAL
ITLLVVEPLL VQCCCLAYEW VLVQRLERAR LVGILAMVGL PGPVLRQLAT KEAKVLDDSD
DDDDDDSSDG GEEGGERDGG SGGGSAATSG NDKMLSIEAE GDGTRRGGDG GGGGDGGSSG
PEAAAVAPPS RPLKFLSVKK ADPSPPASDA SPARNVRHVR TPPDARDGGG SAVAAAAAGD
LVRVGSPVGA VQASGKKQGI RRASWSGDGI NTNQAVGGGG GGGLGGPGAS KGGDMQVMRG
VPDGGSSQPP SRGISRSRGI RINGKLLVPS AANITKFMLP FALWNVALII VYVVSLLDLN
GMQGPLASLN MASHVIYRYT RVRAVAFGLV SQDDAAARSL WRELLRTELR YFESEYDALM
YGGVPITQLH SVFQHAVPPS TFASTAFANE FFREKRCFQY DQSNCQQPGD EYYEVTHNGL
DVMVRRMLSE MNLLVADADE DVAYNGTRNM HLYPDLHTCT PTLTRGHTTT HSYMFIYKVA
ANDLYEGLQQ AAQLFVDYSI SQYNKVGTLH TILLAVTIAL IILYLMFVLW PHLARLRSDA
TRQSALLSHV PPEVDVRSHV RAVFRRAIGR KGRRGAAGRT GGPRTSGAGA GGSGGGGGLL
VAAGSPTAAM AATGV
//
