ID D8TTF2_VOLCA Unreviewed; 780 AA.
AC D8TTF2;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPD {ECO:0000256|ARBA:ARBA00014344};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=VOLCADRAFT_59582 {ECO:0000313|EMBL:EFJ49189.1};
OS Volvox carteri f. nagariensis.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Volvocaceae; Volvox.
OX NCBI_TaxID=3068 {ECO:0000313|Proteomes:UP000001058};
RN [1] {ECO:0000313|EMBL:EFJ49189.1, ECO:0000313|Proteomes:UP000001058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=f. Nagariensis / Eve {ECO:0000313|Proteomes:UP000001058};
RX PubMed=20616280; DOI=10.1126/science.1188800;
RA Prochnik S.E., Umen J., Nedelcu A.M., Hallmann A., Miller S.M., Nishii I.,
RA Ferris P., Kuo A., Mitros T., Fritz-Laylin L.K., Hellsten U., Chapman J.,
RA Simakov O., Rensing S.A., Terry A., Pangilinan J., Kapitonov V., Jurka J.,
RA Salamov A., Shapiro H., Schmutz J., Grimwood J., Lindquist E., Lucas S.,
RA Grigoriev I.V., Schmitt R., Kirk D., Rokhsar D.S.;
RT "Genomic analysis of organismal complexity in the multicellular green alga
RT Volvox carteri.";
RL Science 329:223-226(2010).
CC -!- FUNCTION: Protein transport. Probably involved in vesicular traffic.
CC {ECO:0000256|ARBA:ARBA00025673}.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000256|ARBA:ARBA00009146}.
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DR EMBL; GL378336; EFJ49189.1; -; Genomic_DNA.
DR RefSeq; XP_002949637.1; XM_002949591.1.
DR AlphaFoldDB; D8TTF2; -.
DR STRING; 3068.D8TTF2; -.
DR GeneID; 9618915; -.
DR KEGG; vcn:VOLCADRAFT_59582; -.
DR eggNOG; KOG1131; Eukaryota.
DR InParanoid; D8TTF2; -.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000001058; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR010643; HBB.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR001945; RAD3/XPD.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF1; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF06777; HBB; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR PRINTS; PR00852; XRODRMPGMNTD.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001058}.
FT DOMAIN 7..305
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
SQ SEQUENCE 780 AA; 87544 MW; 5666B471324ABEEA CRC64;
MKFNLEGLTV YFPYEYIYPE QYRYMLELKR ALDARGHCLL EMPTGTGKTI TLLSLITSYQ
LAHKEVGKLI YCTRTVPEME KVLAELAELI DYRAKYLGRG PGSNEILALG LSSRKNLCIH
PRVAEEGSRE SVDAGCRRLT ASWVRERAAE RGARGGEGGA EEGGSGGSVA DIELCDFFEG
HERAGVEALL PPGVYTLSDL RDFGRKRGWC PYFLARHMMA FANVVVYNYQ YMIDPKVSQM
VSRELEKECV VVFDEAHNID NVCIEALSVN LRKQTLEAAG RNLGKLSNSI RRAREADAAR
LQGEYNRLVA GLVAQGALRG GEDWLANPAL PEDVVQETVP GNIRRAEHFM GFLNRFLAFL
REKMASPVVT SQTPQVFLQE LQERVQVDAK TLKFCYDRLS SLLKTLEITN TDEFTPIQLV
ADFATLVGTY AKGFAIIMEP YDERLPQVPD PVLQLSCLDA SLAMKPVFSK FQSVVITSGT
LSPIDLYPRI LNFNPVAIQS FQMTLTRDCL CPVVVTRGAD QMPMSTKFEM RGDPGVMRNY
GRLLVELSAV VPDGIVAFFV SYRYMDQIIS KWHDMGILQE IMQHKLIFIE TQDVVETTLA
LDNFRRACDS GRGAVFLSVA RGKVAEGIDF DRHYGRAVVM FGVPYQYTLS RILRARLEYL
RETFQIKEND YLAFDAVRQA AQCVGRVIRS KADYGMMIFA DKRYQRHDKR DKLPQWITRH
LKEAHMNLST DMMVHVAREF LRAMAQPYDR GAVGKSLLSE AALAALDATG GLDGAIASGA
//
