ID D8TYB1_VOLCA Unreviewed; 2553 AA.
AC D8TYB1;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Topoisomerase 6 subunit A/Spo11 TOPRIM domain-containing protein {ECO:0000259|Pfam:PF21180};
GN ORFNames=VOLCADRAFT_105081 {ECO:0000313|EMBL:EFJ47521.1};
OS Volvox carteri f. nagariensis.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Volvocaceae; Volvox.
OX NCBI_TaxID=3068 {ECO:0000313|Proteomes:UP000001058};
RN [1] {ECO:0000313|EMBL:EFJ47521.1, ECO:0000313|Proteomes:UP000001058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=f. Nagariensis / Eve {ECO:0000313|Proteomes:UP000001058};
RX PubMed=20616280; DOI=10.1126/science.1188800;
RA Prochnik S.E., Umen J., Nedelcu A.M., Hallmann A., Miller S.M., Nishii I.,
RA Ferris P., Kuo A., Mitros T., Fritz-Laylin L.K., Hellsten U., Chapman J.,
RA Simakov O., Rensing S.A., Terry A., Pangilinan J., Kapitonov V., Jurka J.,
RA Salamov A., Shapiro H., Schmutz J., Grimwood J., Lindquist E., Lucas S.,
RA Grigoriev I.V., Schmitt R., Kirk D., Rokhsar D.S.;
RT "Genomic analysis of organismal complexity in the multicellular green alga
RT Volvox carteri.";
RL Science 329:223-226(2010).
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DR EMBL; GL378344; EFJ47521.1; -; Genomic_DNA.
DR RefSeq; XP_002951345.1; XM_002951299.1.
DR STRING; 3068.D8TYB1; -.
DR GeneID; 9615505; -.
DR KEGG; vcn:VOLCADRAFT_105081; -.
DR eggNOG; KOG2795; Eukaryota.
DR InParanoid; D8TYB1; -.
DR OrthoDB; 169019at2759; -.
DR Proteomes; UP000001058; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:InterPro.
DR GO; GO:0022414; P:reproductive process; IEA:UniProt.
DR GO; GO:0019953; P:sexual reproduction; IEA:UniProt.
DR CDD; cd00223; TOPRIM_TopoIIB_SPO; 1.
DR Gene3D; 3.40.1360.10; -; 1.
DR InterPro; IPR002815; Spo11/TopoVI_A.
DR InterPro; IPR036078; Spo11/TopoVI_A_sf.
DR InterPro; IPR034136; TOPRIM_Topo6A/Spo11.
DR PANTHER; PTHR10848; MEIOTIC RECOMBINATION PROTEIN SPO11; 1.
DR PANTHER; PTHR10848:SF0; MEIOTIC RECOMBINATION PROTEIN SPO11; 1.
DR Pfam; PF21180; TOP6A-Spo11_Toprim; 1.
DR PRINTS; PR01550; TOP6AFAMILY.
DR SUPFAM; SSF56726; DNA topoisomerase IV, alpha subunit; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001058}.
FT DOMAIN 132..279
FT /note="Topoisomerase 6 subunit A/Spo11 TOPRIM"
FT /evidence="ECO:0000259|Pfam:PF21180"
FT REGION 292..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1042..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1187..1232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1245..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1544..1570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1587..1622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1655..1676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1779..1807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1943..2018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2053..2159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2224..2292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2478..2502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 963..990
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 294..309
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1191..1212
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1346..1360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1601..1622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2081..2110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2135..2155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2248..2262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2487..2501
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2553 AA; 261212 MW; 91C78E1C7E294E7F CRC64;
MYACVCEGAC VRLESVLAVL NAVHDLLRQG RQATQRDLYY TRPGGDVCGA WGGGGAAAAA
RRTRFTLGGL QYRRWEWVGP SGRALPGDMA TIARFGLQLM SPAAAAAAAA GGSAAAAAAA
GGSGGGSGGS CYLLVVEKDA VFQRLAEDRI WDHLPCVLLT ARGMPDLATR AFAARLAASF
PAPRLQPVGL VDYNPAGVVI LATYKYGSDR LGPEGRAHLL PGLRWLGLRS RQLADVEHHH
LQPLSERDRV MVRGLRERLG DMEPGWAGEL DVMEASGYKG GGKRDAQAKI KHQHTHSAAP
HRHRAPRRKG EQKMPWNVQS PDEPKAQRRH RGGVPGGCRN LGKIRTLVKS GLDPNGLVSN
TSCFDNTTWV LKDRKPLVPL LVFSCFNGVP AAVLDLLIRL GALPNAVTDC GLPAPLAVLC
AKITAEEHRA LFQVLRQHRC STFNSSVCSA RNDHPIHITC KVLDLSDWTS PRKVEGIELL
IKFGTFQLSD GGLDERAMYD FVATAVRHSC GHKLLDCLWR HFPQQLLPSL PASDCLLLRA
LADSWLEPFW RRSAERQHTV SMGLVLRALL EHPAMQPPQR EAVAYWLRTN MAVLLYRPEL
VALLLDRCRV CPAQSTSSRA ASGPGSPVSP RSAAATAAAV PLHFHPDDRD LVLPVGLLSG
PEAAQGDVPL APGMSLMLAY VVDPDEQLAR QGGIHAVPPQ PCPRERLLDL LDSNVLDYVD
NRNLDLVEVT LAELLPQLAS LSPSAAAAAD LDDDQGAAGG SGVTLSDGGI GDRGGGDGSR
SAACGGGRSD GKGAAANLAA QLSVVSERLE RAHACLDELY DSERSDAELA NDPEVWRAEA
AVEALAAVQR CLQRAATAAA GGDGDASARF RCELSTGVAF VDVVAARIVG QPEWGFSRGL
LLQLGLCQMR RALRSLQAAA GSGGAADRGA DGGVQGVEAQ MEVLRLYFEE LLADTSVSER
RLLEDLVSAL EAAERERDLE EAQVAEEVAA AAAAAAAAAV TTAAMETNTE ASHALQPPRA
TEYGSMAEIP YDANPSEALL RGMTKPLSPP PPQRQQQMHE VVGRCEQEEA QQETEGQNID
VALVPRAGVE GGDGGSDGCG GSAGQQLSAC SSRHPSSSSC RCDSSSSSGV SGSVGNIGGP
EAAAAATTLP VVADSTAATA AAMAAMRQAF LTPQARAAMH RAMLPGESMG EWTSDDEDGS
DGGDDDDDDD DIGVGGGRGG SSSSAESWRR QAKDVAVSAR GVGDAVADSG ASQGSNAGCS
RSIFAGRGGS GVKGKGSCST RRCALENGSD TLGAGPGRQC SQLSPNLAKP PPPPPQQQQQ
AQQMRQVQQR RRRLKLVGVV DGGAATGRRR RGRRLYGSES GAERPEGFST PTVDGWRDPD
LLLGGLNVMS LPPNIRHGSG GCGGSGSSSD SSGRELAPYE YLGAAVMFQD YEDSGSGGSS
DANAGFGVGV GVRCNGSAAS SAYDTPSEGS GGDAASLLEA QARGWSGGGA ADAVVAAAAA
PRRLSHSSDQ SSELSYGSAQ GGYGSVHGYG PEYGLESVGG DMGALDSGVA NRPTCGGSSN
SGGGGGGASR RDMHTIAAAA ALAMASATGG SGPAPLPAPQ GGGNITQQRR HRNGSGQQSK
HAAMRSLSCR AAYAAGPTVA VSYYERANGC DSVTSMEQSG DLRGLRTSVP DGSGTPSTAG
VNAMVLMAER PLACHVSSST SCPSASAASS SSPSGASCCS SLDSTRACIV HKPFVATAGA
TEARRWSRVP TKPHVQIRAL EPPAAVAAAA AAAAAVLQPP SERHTASIHT YSRPPEGGGG
GDSSGDEYVH TYDASNEYAA EGVCIMKPTG SSAAAKEDSA VNGRQRYDAN APAYGDLDDS
GVGLGRRGDV RSGGGGAAAA AIGATARAET AGGRRRAVVR RTRAKQTPLV VAEAASPLRQ
QAASSPPPLP ALLLPQSFGL RSCSDASAGN ETESSDSGGR RRRSTSKVSY GSDGSVVATV
APRRPAASSS GGGGAGEDVD ASDDASSTST QEWPPRRPPA IAKSITLAAG SFPDVSTATA
VAPIATAVAP IATDASSEND SDAPGSVGFS GRRPEHGSSE DFGSGSGSET EPGGSTEGRR
TTATRSSTVP QPAPPSLPLQ SGSNSEFRGN DKCRCRSASA TSSDSSVTSR PTPVGGNAVA
TRPESLVAAA GRRRCAAAAD GAIDAVAASE EISISRLCLA APFTAAAATA ATATAAPAVA
VLAEEKEDGS DGDSRGYGSV TEGVGADHNG VDGDDEDGSP DMSGRRQQQQ HCPVASAQPP
PEVAAPAPAT GPVSLSAHTA AAAADKTLAA LLSNLATSAN VLPRPAGAIP NRGSDPIGAA
SGGGGVKRPR SGACTWFGDG TAAAATAAAA AGGSMPSSCC YVLRLSGGGG AAAGECAGVP
PPDAVMRALS NGPCGPEALY SWAGELRTAL VTSSGCVHQR LLVVADSTTR APGPTWLTAL
RAAVAGAVLG PVLDGAGAGS GGGDARSGGG RRRDHPMGGG GRRRYCPDWL RQTVLLLPLS
HLIVPYGGSY LYQAASRAYQ GKTTFGRRFA HEM
//
