ID D8U2I3_VOLCA Unreviewed; 784 AA.
AC D8U2I3;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=6-phosphofructo-2-kinase domain-containing protein {ECO:0000259|Pfam:PF01591};
GN ORFNames=VOLCADRAFT_105711 {ECO:0000313|EMBL:EFJ46141.1};
OS Volvox carteri f. nagariensis.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Volvocaceae; Volvox.
OX NCBI_TaxID=3068 {ECO:0000313|Proteomes:UP000001058};
RN [1] {ECO:0000313|EMBL:EFJ46141.1, ECO:0000313|Proteomes:UP000001058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=f. Nagariensis / Eve {ECO:0000313|Proteomes:UP000001058};
RX PubMed=20616280; DOI=10.1126/science.1188800;
RA Prochnik S.E., Umen J., Nedelcu A.M., Hallmann A., Miller S.M., Nishii I.,
RA Ferris P., Kuo A., Mitros T., Fritz-Laylin L.K., Hellsten U., Chapman J.,
RA Simakov O., Rensing S.A., Terry A., Pangilinan J., Kapitonov V., Jurka J.,
RA Salamov A., Shapiro H., Schmutz J., Grimwood J., Lindquist E., Lucas S.,
RA Grigoriev I.V., Schmitt R., Kirk D., Rokhsar D.S.;
RT "Genomic analysis of organismal complexity in the multicellular green alga
RT Volvox carteri.";
RL Science 329:223-226(2010).
CC -!- FUNCTION: Protein transport. Probably involved in vesicular traffic.
CC {ECO:0000256|ARBA:ARBA00025673}.
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DR EMBL; GL378353; EFJ46141.1; -; Genomic_DNA.
DR RefSeq; XP_002952891.1; XM_002952845.1.
DR AlphaFoldDB; D8U2I3; -.
DR STRING; 3068.D8U2I3; -.
DR GeneID; 9627701; -.
DR KEGG; vcn:VOLCADRAFT_105711; -.
DR eggNOG; KOG0234; Eukaryota.
DR InParanoid; D8U2I3; -.
DR OrthoDB; 2013830at2759; -.
DR Proteomes; UP000001058; Unassembled WGS sequence.
DR GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR GO; GO:0006000; P:fructose metabolic process; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR003094; 6Pfruct_kin.
DR InterPro; IPR013079; 6Phosfructo_kin.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001345; PG/BPGM_mutase_AS.
DR PANTHER; PTHR10606:SF44; 6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM; 1.
DR PANTHER; PTHR10606; 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE; 1.
DR Pfam; PF01591; 6PF2K; 2.
DR Pfam; PF00300; His_Phos_1; 1.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00175; PG_MUTASE; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001058}.
FT DOMAIN 314..372
FT /note="6-phosphofructo-2-kinase"
FT /evidence="ECO:0000259|Pfam:PF01591"
FT DOMAIN 373..431
FT /note="6-phosphofructo-2-kinase"
FT /evidence="ECO:0000259|Pfam:PF01591"
FT REGION 1..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..754
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 447
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT ACT_SITE 536
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT BINDING 446..453
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
FT BINDING 500
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
FT BINDING 547
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 784 AA; 80218 MW; EEF216B8F2FB9816 CRC64;
MLQVLSPSPL GLATPLPNPS SSTHPATTPL GCQPESQPQP ESQNSALLPS LASRSAPISA
SNPAHSLEAQ QSTSYNQLTP GGGGGGPLHV ASSSSFHPGG GSGAAGTTRG SASVSLNGIN
GGVSLRGNSG SSLGRSMLLF PSTAELARRL RGLVTNAAVN FRDVELMPKP QPPEGDMEGL
MEGLMDQQGE EPDADAATGS TAASASLAAA AAEVIGRNGS GGGGGGGAAA AAAAAGGVGA
GSDGDGSGDD GGHGAADGAA AAAAAAVAAA GGLPLPPMPL AAGVVAGVSA GCSRVRTSGA
VVRKNKLVII MRHADQMQDA EFFDHTNEAG LEARHRALNA ALDDLTAWLR SDQGQVAVFD
ATNTTESRRN LLAVADFLAR ISKYEEVYEP INDRNLHYIK LIDMVTGRGH MDINRISGYL
PGKIVFFLMQ ICKAGMTSVR KIWLSRHGES EYNQKGLIGG NSSLSERGER YSRALPGALI
ARLPQEQPVS VAVWTSTLKR TIETARFLPF PKLRWKALDE IDAGICDGMT YEQIAERYPQ
EYEARKKDKL RYRYPSGESY MDVIQRVEPV IIELERERES VLVVAHQAVL RAVYAYFMNV
PPEDIPRLSM PLHTLIELTP MPDGTMSEQR FPLDIDIGVG VGVGIDVEVV QEPAVGGPSA
VGPSGPAAKG VVDGDGAARG AAECFAAAAE EVATEMAAAA AAAAAEAAGS GSPLSSVNSG
GSCMAMMMSM QEGGGSLVLP ASPASSSPGS ATTGRDDEAV TDVVEAMGLA AGPAAAAAAV
ATAQ
//
