ID D8VEL4_ANODA Unreviewed; 117 AA.
AC D8VEL4;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000256|ARBA:ARBA00021007, ECO:0000256|RuleBase:RU003640};
DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003640};
GN Name=ND3 {ECO:0000313|EMBL:ACX49704.1};
OS Anopheles darlingi (Mosquito).
OG Mitochondrion {ECO:0000313|EMBL:ACX49704.1}.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151;
RN [1] {ECO:0000313|EMBL:ACX49704.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Northern {ECO:0000313|EMBL:ACX49704.1};
RX PubMed=20470395; DOI=10.1186/1475-2875-9-127;
RA Moreno M., Marinotti O., Krzywinski J., Tadei W.P., James A.A., Achee N.L.,
RA Conn J.E.;
RT "Complete mtDNA genomes of Anopheles darlingi and an approach to anopheline
RT divergence time.";
RL Malar. J. 9:127-127(2010).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity of complex I.
CC {ECO:0000256|RuleBase:RU003640}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000766,
CC ECO:0000256|RuleBase:RU003640};
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000256|RuleBase:RU003640}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU003640}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family.
CC {ECO:0000256|ARBA:ARBA00008472, ECO:0000256|RuleBase:RU003640}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GQ918272; ACX49704.1; -; Genomic_DNA.
DR RefSeq; YP_003734747.1; NC_014275.1.
DR AlphaFoldDB; D8VEL4; -.
DR STRING; 43151.D8VEL4; -.
DR VEuPathDB; VectorBase:ADAC010716; -.
DR eggNOG; KOG4662; Eukaryota.
DR InParanoid; D8VEL4; -.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.58.1610; NADH:ubiquinone/plastoquinone oxidoreductase, chain 3; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1.
DR PANTHER; PTHR11058:SF9; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|RuleBase:RU003640};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003640};
KW Mitochondrion {ECO:0000256|RuleBase:RU003640, ECO:0000313|EMBL:ACX49704.1};
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003640};
KW Respiratory chain {ECO:0000256|RuleBase:RU003640};
KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU003640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003640};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003640};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003640};
KW Ubiquinone {ECO:0000256|RuleBase:RU003640}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003640"
FT TRANSMEM 57..80
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003640"
FT TRANSMEM 86..105
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003640"
SQ SEQUENCE 117 AA; 13586 MW; 2E617B6B4F9DCE7A CRC64;
MLMLSMMTLI IMIITIVVMM LATLLSKKTL TDREKCSPFE CGFDPMNSSR LPFSLRFFLI
AIIFLIFDVE IALLLPMIMI IKSSNLINWT ITSLFFIFIL IVGLYHEWNQ GALEWNE
//
