ID D9I3F4_9BETR Unreviewed; 874 AA.
AC D9I3F4;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Gag-pro-pol protein {ECO:0000313|EMBL:ADI50273.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ADI50273.1};
OS Enzootic nasal tumour virus of goats.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Betaretrovirus.
OX NCBI_TaxID=239365 {ECO:0000313|EMBL:ADI50273.1};
RN [1] {ECO:0000313|EMBL:ADI50273.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ENTV-SC {ECO:0000313|EMBL:ADI50273.1};
RA Feng Y.C., Yan Q.G., Zhang G.J., Chen Y.;
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; HM104174; ADI50273.1; -; Genomic_RNA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd09273; RNase_HI_RT_Bel; 1.
DR CDD; cd01645; RT_Rtv; 1.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 2.30.30.10; Integrase, C-terminal domain superfamily, retroviral; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
DR InterPro; IPR001037; Integrase_C_retrovir.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR010661; RVT_thumb.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00552; IN_DBD_C; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF06817; RVT_thumb; 1.
DR SUPFAM; SSF50122; DNA-binding domain of retroviral integrase; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS51027; INTEGRASE_DBD; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 4: Predicted;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00450}.
FT DOMAIN 55..243
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 457..588
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT DOMAIN 590..631
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 644..803
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 809..858
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS51027"
FT DNA_BIND 809..858
FT /note="Integrase-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00506"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADI50273.1"
SQ SEQUENCE 874 AA; 99688 MW; 876DDC9E0881FB38 CRC64;
SKSKGLGVFS LGTSDSPVTH ADPIDWKSEE PVWVDQWPLT QEKLSAAQQL VQEQLRLGHI
EPSTSAWNSP IFVIKKKSGK WRLLQDLRKV NETMMHMGAL QPGLPTPSAI PDKSYIIIID
LKDCFYTIPL APQDCKRFAF SLPSVNFKEP MQRYQWRVLP QGMTNSPTLC QKFVATALAP
VRQRFPQLYL VHYMDDILLA HADEHLLYQA FSILKKHLSL NGLVIADEKI QTHFPYNYLG
FSLYPRVYNT QLVKLQTDHL KTLNDFQKLL GDINWIRPYL KLPTYTLQPL FDILKGDSDP
ASPRTLSSEG RSALQSIEEA IRQQQITYCD YQRPWGLYIL PTPRAPTGVL YQDKPLRWIY
LSATPTKHPL PYYELVAKTV AKGHHEAIQY FGIEPPFICI PYALEQQDWL FQFSDNWSIA
FANYPGRITH HYPSDKLLQF ASFHAFIFPK IVRRQPIPEA TLIFTDGSSN GTAALIINHQ
TYYAHTSFSS AQVVELFAVR QVLLTVSTSF NVFTESSYVV GALQMIETVP IIGTTSPEVL
NLFKLIQQAL HRRQYPCFFG HIRAHSTLPG ALVQGNHTAD VLTKQVFFQS AINAAKKSHN
LHHQNSHSLR LQFKISREAA RQIVKSCSTC PQFFVLPQYG INPRGLRPNH LWQTDVTHIP
QFGRLKYVHV SIDTFSHFLM ASLHTGESTR HCIQHLLFCF SISGIPQTLK TDNGPGYTGR
SFQRFCLSFQ IQHKTGIPYN PQGQGIVERA HQRLKHQLLK QKKGNDLYSP SPHNALNHAL
YVLNFLTLDA EGNSAAQRFW GERSSCKKPL VQWKDPLTNL WHGPDPVLIW GRGHVCVFPQ
DAEAPRWIPE RLVRAAEELP NASNASHDIE RAYE
//
