ID D9J0C4_HUMAN Unreviewed; 198 AA.
AC D9J0C4;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE RecName: Full=Sex-determining region Y protein {ECO:0000256|ARBA:ARBA00019052};
DE AltName: Full=Testis-determining factor {ECO:0000256|ARBA:ARBA00032498};
DE Flags: Fragment;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ADJ00514.1};
RN [1] {ECO:0000313|EMBL:ADJ00514.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Az6 {ECO:0000313|EMBL:ADJ00514.1};
RA Khan F.H., Ganesan P., Reza M.J., Anirudh A., Somvanshi P., Kumar S.;
RT "Sequence variability and phylogenetic relationship of SRY gene in
RT infertile men from general population of Lucknow, India.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the SRY family. {ECO:0000256|ARBA:ARBA00005998}.
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DR EMBL; HM241140; ADJ00514.1; -; Genomic_DNA.
DR AlphaFoldDB; D9J0C4; -.
DR SMR; D9J0C4; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0030238; P:male sex determination; IEA:InterPro.
DR GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR CDD; cd22034; HMG-box_SoxA_SRY; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR017253; SRY.
DR PANTHER; PTHR10270:SF199; SEX-DETERMINING REGION Y PROTEIN; 1.
DR PANTHER; PTHR10270; SOX TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PIRSF; PIRSF037653; SRY; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Sexual differentiation {ECO:0000256|ARBA:ARBA00022928};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 60..128
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 60..128
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 175..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 198
FT /evidence="ECO:0000313|EMBL:ADJ00514.1"
SQ SEQUENCE 198 AA; 23155 MW; 7025C71190305475 CRC64;
MQSYASAMLS VFNSDDYSPA VQENIPAHRR SSSFLCTESC NSKYQCETGE NSKGNVQDRV
KRPMNAFIVW SRDQRRKMAL ENPRMRNSEI SKQLGYQWKM LTEAEKWPFF QEAQKLQAMH
REKYPNYKYR PRRKAKMLPK NCSLLPADPA SVLCSEVQLD NRLYRDDCTK ATHSRMEHQL
GHLPPINAAS SPQQRDRY
//
