ID D9MN98_PTEQU Unreviewed; 237 AA.
AC D9MN98;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Taste receptor type 1 member 2 {ECO:0000256|ARBA:ARBA00040704};
DE AltName: Full=Sweet taste receptor T1R2 {ECO:0000256|ARBA:ARBA00042616};
DE Flags: Fragment;
GN Name=Tas1r2 {ECO:0000313|EMBL:ADJ37103.1};
OS Pteronotus quadridens (Sooty mustached bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Mormoopidae;
OC Pteronotus.
OX NCBI_TaxID=118854 {ECO:0000313|EMBL:ADJ37103.1};
RN [1] {ECO:0000313|EMBL:ADJ37103.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20558596; DOI=10.1093/molbev/msq152;
RA Zhao H., Zhou Y., Pinto C.M., Charles-Dominique P., Galindo-Gonzalez J.,
RA Zhang S., Zhang J.;
RT "Evolution of the sweet taste receptor gene Tas1r2 in bats.";
RL Mol. Biol. Evol. 0:0-0(2010).
CC -!- FUNCTION: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse
CC natural and synthetic sweeteners. {ECO:0000256|ARBA:ARBA00037659}.
CC -!- SUBUNIT: Forms heterodimers with TAS1R3.
CC {ECO:0000256|ARBA:ARBA00038699}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000256|ARBA:ARBA00038492}.
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DR EMBL; HM437938; ADJ37103.1; -; Genomic_DNA.
DR AlphaFoldDB; D9MN98; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF517; TASTE RECEPTOR TYPE 1 MEMBER 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ADJ37103.1};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Taste {ECO:0000256|ARBA:ARBA00022480};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..228
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADJ37103.1"
FT NON_TER 237
FT /evidence="ECO:0000313|EMBL:ADJ37103.1"
SQ SEQUENCE 237 AA; 26473 MW; 8E2C58FDC0EE9A36 CRC64;
LAFLQWHEAP TIAVAMLAAL GFLSTLAILV ILWKHFQTPM VRSAGGPMCF LMLVPLLVAY
MMVPTYVGPP TVSTCLCRQT FFTLCFTICI SCIAVRSFQI ICIFKMASRL PRAYGYWVRY
HGSYIFVALM TAVKVVIVVG SLLLTTTRPT AYPDPDDPKI MILSCNPNYR KVLLVNTSLD
LLLSVMGFSF AYVGKELPTN YNEAKFITFC MTFYFTSSVS LCTFMSAYKG VLVTILD
//
