ID D9MNM2_9VIRU Unreviewed; 516 AA.
AC D9MNM2;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 03-MAY-2023, entry version 41.
DE RecName: Full=Non-structural polyprotein 1AB {ECO:0000256|ARBA:ARBA00019743};
DE Flags: Fragment;
GN Name=ORF1b {ECO:0000313|EMBL:ADJ38390.1};
OS Astrovirus rat/RS118/HKG/2007.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC Stellavirales; Astroviridae.
OX NCBI_TaxID=858506 {ECO:0000313|EMBL:ADJ38390.1};
RN [1] {ECO:0000313|EMBL:ADJ38390.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RS118 {ECO:0000313|EMBL:ADJ38390.1};
RX PubMed=20554799; DOI=10.1099/vir.0.022764-0;
RA Chu D.K., Chin A.W., Smith G.J., Chan K.H., Guan Y., Peiris J.S.,
RA Poon L.L.;
RT "Detection of novel astroviruses in urban brown rats and previously known
RT astroviruses in humans.";
RL J. Gen. Virol. 91:2457-2462(2010).
RN [2] {ECO:0000313|EMBL:ADJ38390.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RS118 {ECO:0000313|EMBL:ADJ38390.1};
RA Chu D.K.W., Chin A.W.H., Smith G.J., Chan K.H., Guan Y., Peiris J.S.,
RA Poon L.L.M.;
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Contains the viral protease participating in the cleavage of
CC the polyprotein into functional products. It contains also the
CC activities necessary for replication of genomic RNA, as well as
CC transcription of subgenomic mRNA. {ECO:0000256|ARBA:ARBA00029407}.
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000256|ARBA:ARBA00004301};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004301}.
CC -!- SIMILARITY: Belongs to the astroviridae polyprotein 1AB family.
CC {ECO:0000256|ARBA:ARBA00005873}.
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DR EMBL; HM450381; ADJ38390.1; -; Genomic_RNA.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23172; ps-ssRNAv_Astroviridae_RdRp; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00680; RdRP_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 261..387
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADJ38390.1"
SQ SEQUENCE 516 AA; 60673 MW; 08194A47014A431F CRC64;
KKREKGPQAG PKEWYQLDYW RLLVTPGVRR RLVPDDYPLV GVVPMNRPIC DFDEPVDPHL
GVLPPPPKVQ QLEDYGPTIW DESAYLKSFE KFYYAEPSDF FQDYPELCAF ADAAFRKHFS
FLQDTRVVHI TATEKNLDSS PAYPKLCWYS TERDFLEEQM WAPYIKEFAR VDRLTKDGKG
PRVLWYCFLK KEILKAQKIK DGDIRQILCA DPIYSRMGAC FEQHQNQLMK EMADVSSGQC
GWTPFEGGFR AVCERLQEKN GVFIEFDWTR FDGTIPTCLF LHIKKLRWSF MEKTHQERYG
KMYRWYCKNL VDRYVVMPSG EVTKQKRGNP SGQISTTMDN NMVNYWLQAF EWAWFNGPDF
EKFNEFETVV YGDDRLSTWS RVPDDFSTLA SDMYRRVFGM WVKPEKVKVS SQLEGLSFCG
FTIGPGFNPR PAEPFKLMAS LLKPSKKLPD YLALHGKLLC YQILMHFVED EHPFKRYVLR
CLDVTWRLSG KKLLRRFTEQ QLNALWWGGP KKCDGR
//
