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Database: UniProt
Entry: D9RUT9_PREMB
LinkDB: D9RUT9_PREMB
Original site: D9RUT9_PREMB 
ID   D9RUT9_PREMB            Unreviewed;       468 AA.
AC   D9RUT9;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   25-OCT-2017, entry version 53.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:ADK96742.1};
GN   OrderedLocusNames=HMPREF0659_A6416 {ECO:0000313|EMBL:ADK96742.1};
OS   Prevotella melaninogenica (strain ATCC 25845 / DSM 7089 / JCM 6325 /
OS   VPI 2381 / B282) (Bacteroides melaninogenicus).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=553174 {ECO:0000313|EMBL:ADK96742.1, ECO:0000313|Proteomes:UP000001498};
RN   [1] {ECO:0000313|Proteomes:UP000001498}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25845 / DSM 7089 / JCM 6325 / VPI 2381 / B282
RC   {ECO:0000313|Proteomes:UP000001498};
RA   Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B.,
RA   Sutton G.G., Nelson K.E.;
RT   "Genome sequence of Prevotella melaninogenica strain ATCC 25845.";
RL   Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP002123; ADK96742.1; -; Genomic_DNA.
DR   RefSeq; WP_013265222.1; NC_014371.1.
DR   STRING; 553174.HMPREF0659_A6416; -.
DR   PRIDE; D9RUT9; -.
DR   EnsemblBacteria; ADK96742; ADK96742; HMPREF0659_A6416.
DR   GeneID; 9498194; -.
DR   KEGG; pmz:HMPREF0659_A6416; -.
DR   PATRIC; fig|553174.6.peg.1396; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; VENWVKD; -.
DR   Proteomes; UP000001498; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001498};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001498}.
FT   DOMAIN      163    295       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      374    443       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     171    178       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   468 AA;  53375 MW;  63FAA612399DFB4D CRC64;
     MNVSPKNLWD SCLQLIKENV TEQQFDTWFR PIVLQSYKPA SKTLLVQVPS QFVYEYLEGH
     YVDLLRKVLT RVFGQGVQLT YRVMVDQENH LSQDLEQDTV EDISSQRPTA RANQSPTVLD
     TVPQDLDSQL DPHKSFSNYV EGDSNKLPRS IGLSIAEHPN TTQFNPMFIY GPSGCGKTHL
     VNAIGLKAKQ LYPQKRVLYV SARLFQVQYT DSVRQNTTND FINFYQTIDI LIVDDIQEWV
     TATKTQDTFF HIFNHLFRNG KRIILASDRP PVDLKGMNDR LLTRFSCGLI AELEKPNVQL
     CVDILHSKIK RDGLNIPEDV VRFIAETANG SVRDLQGVIN SLLAYSVVYN SNIDMRLAER
     VIKRAVKIDD EPLTIDDILD KVCTHYNVTM SAVNSRSRKK DIVMARQVSM YMAQKYTKMP
     ASRIGKLVGN RDHSTVIHSC SKIEDRLKVD KGFHAEIASI ENSFKLKA
//
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