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Database: UniProt
Entry: D9T2Y7_MICAI
LinkDB: D9T2Y7_MICAI
Original site: D9T2Y7_MICAI 
ID   D9T2Y7_MICAI            Unreviewed;       607 AA.
AC   D9T2Y7;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   05-JUL-2017, entry version 52.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Micau_0001 {ECO:0000313|EMBL:ADL43570.1};
OS   Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / BCRC 12538
OS   / CBS 129.76 / JCM 10878 / NBRC 16125 / NRRL B-16091 / INA 9442).
OC   Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC   Micromonospora.
OX   NCBI_TaxID=644283 {ECO:0000313|EMBL:ADL43570.1, ECO:0000313|Proteomes:UP000001908};
RN   [1] {ECO:0000313|EMBL:ADL43570.1, ECO:0000313|Proteomes:UP000001908}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442
RC   {ECO:0000313|Proteomes:UP000001908};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N.,
RA   Ovchinnikova G., Hirsch A.M., Woyke T.;
RT   "Complete sequence of Micromonospora aurantiaca ATCC 27029.";
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP002162; ADL43570.1; -; Genomic_DNA.
DR   RefSeq; WP_013283211.1; NC_014391.1.
DR   ProteinModelPortal; D9T2Y7; -.
DR   STRING; 644283.Micau_0001; -.
DR   EnsemblBacteria; ADL43570; ADL43570; Micau_0001.
DR   GeneID; 32160650; -.
DR   KEGG; mau:Micau_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; ATHIERN; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000001908; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001908};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001908}.
FT   DOMAIN      301    429       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      513    582       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     309    316       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   607 AA;  66993 MW;  43F8359F989EB0CE CRC64;
     MTGATDLAAV WTATTDELAD EIISAQQRAY LRLTRLRAIV EDTALLSVPD AFTRDVIESR
     LRPAITEALS RRLGRPIQVA VTVRVSDDPS ARPAGTVYRS GPEPLPEHDA AAPLPGFDQP
     ASAFPSPRPE PGYAEAGYAE PRPEQPLDEP APRQRTADGG GRPHLIPAGR DAQDTLFSAA
     FAEPVRTAPE RRAFDERTRI EPPVPDAGGY EPRYRESPPA DPAPMRGLPR DGATDNGPGR
     GGADHHRPGG GGQADRRLPG GTESGGNRLN PKYMFETFVI GSSNRFAHAA SVAVAESPAK
     AYNPLFIYGS SGLGKTHLLH AIGHYATTLG NARSVRYVST EEFTNDFINS LRDDKTSAFQ
     RRYRDVDILL IDDIQFLENR ERTQEEFFHT FNTLHNANKQ IVITSDRSPK QLATLEDRLR
     TRFEWGLLAD IQPPDLETRI AILQKKAAQE RLFAPPDVLE FIASRVSNSI RELEGALIRV
     TAFASLTRSS VELSLAEEVL RDFIPDGAGP EITADQIMVS TADYFGVSLE DLRGHSRSRV
     LVNARQVAMY LCRELTDLSL PRIGQAFGGR DHTTVMHADR KIRQQMAERR SLYNQIAELT
     NRIKQNT
//
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