ID D9TGP6_CALOO Unreviewed; 454 AA.
AC D9TGP6;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|ARBA:ARBA00018893, ECO:0000256|HAMAP-Rule:MF_00377};
GN Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN ECO:0000313|EMBL:ADL41382.1};
GN OrderedLocusNames=COB47_0001 {ECO:0000313|EMBL:ADL41382.1};
OS Caldicellulosiruptor obsidiansis (strain ATCC BAA-2073 / strain OB47).
OC Bacteria; Bacillota; Clostridia; Caldicellulosiruptorales;
OC Caldicellulosiruptoraceae; Caldicellulosiruptor.
OX NCBI_TaxID=608506 {ECO:0000313|EMBL:ADL41382.1, ECO:0000313|Proteomes:UP000000347};
RN [1] {ECO:0000313|EMBL:ADL41382.1, ECO:0000313|Proteomes:UP000000347}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-2073 / strain OB47
RC {ECO:0000313|Proteomes:UP000000347};
RX PubMed=20851897; DOI=10.1128/JB.00950-10;
RA Elkins J.G., Lochner A., Hamilton-Brehm S.D., Davenport K.W., Podar M.,
RA Brown S.D., Land M.L., Hauser L.J., Klingeman D.M., Raman B., Goodwin L.A.,
RA Tapia R., Meincke L.J., Detter J.C., Bruce D.C., Han C.S., Palumbo A.V.,
RA Cottingham R.W., Keller M., Graham D.E.;
RT "Complete genome sequence of the cellulolytic thermophile
RT Caldicellulosiruptor obsidiansis OB47T.";
RL J. Bacteriol. 192:6099-6100(2010).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00377}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|ARBA:ARBA00006583,
CC ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU004227}.
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DR EMBL; CP002164; ADL41382.1; -; Genomic_DNA.
DR RefSeq; WP_013289389.1; NC_014392.1.
DR AlphaFoldDB; D9TGP6; -.
DR STRING; 608506.COB47_0001; -.
DR KEGG; cob:COB47_0001; -.
DR eggNOG; COG0593; Bacteria.
DR HOGENOM; CLU_026910_3_1_9; -.
DR OrthoDB; 9807019at2; -.
DR Proteomes; UP000000347; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd00009; AAA; 1.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR NCBIfam; TIGR00362; DnaA; 1.
DR PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR PANTHER; PTHR30050:SF2; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48295; TrpR-like; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00377};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00377};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_00377};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00377};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00377}.
FT DOMAIN 146..274
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 360..429
FT /note="Chromosomal replication initiator DnaA C-terminal"
FT /evidence="ECO:0000259|SMART:SM00760"
FT BINDING 154..161
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00377"
SQ SEQUENCE 454 AA; 52353 MW; C387E229CDCD88AD CRC64;
MVDYDVNEVW EKVKEAVKKE INPSPTDISY NTWFESLVPL CFDDNDTLIL KAFADFHRDI
VINRYSIVIL NALRQLFSPH LSIKVILPEE VEKYKKFLKS KQDEKLEIVT QLNPKYTFET
FVVGNNNRLA HAAALAVAET PPGERTYNPL FIYGGVGLGK THLMHAIGHH VLKLYPGTKV
MYVTSEIFTN ELIAAIRDEK TDEFRLKYRN VDVLLIDDIQ FLGGKERTQE EFFHTFNTLY
EANKKIILSS DRPPKEINTL EDRLRSRFEW GLITDIQPPD FETRIAILSK KCQLEGTPVP
QHILEFIASK IETNIRELEG ALNKILAYSK LMAPDKEITL ELAEKALKEF IDTNTKKELT
IEDIQAEVAS YFNIRLEDFK SSRRSRNVAF PRQIAMYLAR ELTNVSLPKI GEAFGGKDHT
TVLHACEKIK ELINKDTNTR NAVENIKKRL IHRE
//
