GenomeNet

Database: UniProt
Entry: D9TRH5_THETC
LinkDB: D9TRH5_THETC
Original site: D9TRH5_THETC 
ID   D9TRH5_THETC            Unreviewed;       273 AA.
AC   D9TRH5;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=Cyanophycinase {ECO:0000256|ARBA:ARBA00015719};
DE            EC=3.4.15.6 {ECO:0000256|ARBA:ARBA00013115};
GN   OrderedLocusNames=Tthe_2741 {ECO:0000313|EMBL:ADL70183.1};
OS   Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 /
OS   NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM 00135 / 2032) (Clostridium
OS   thermosaccharolyticum).
OC   Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Thermoanaerobacterium.
OX   NCBI_TaxID=580327 {ECO:0000313|EMBL:ADL70183.1, ECO:0000313|Proteomes:UP000001626};
RN   [1] {ECO:0000313|EMBL:ADL70183.1, ECO:0000313|Proteomes:UP000001626}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM
RC   00135 / 2032 {ECO:0000313|Proteomes:UP000001626};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA   Hemme C.L., Woyke T.;
RT   "Complete sequence of Thermoanaerobacterium thermosaccharolyticum DSM
RT   571.";
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exopeptidase that catalyzes the hydrolytic cleavage of multi-
CC       L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve
CC       polymer) into aspartate-arginine dipeptides.
CC       {ECO:0000256|ARBA:ARBA00002039}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-
CC         2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate;
CC         Xref=Rhea:RHEA:12845, Rhea:RHEA-COMP:13728, Rhea:RHEA-COMP:13734,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:137986, ChEBI:CHEBI:137991;
CC         EC=3.4.15.6; Evidence={ECO:0000256|ARBA:ARBA00001092};
CC   -!- SIMILARITY: Belongs to the peptidase S51 family.
CC       {ECO:0000256|ARBA:ARBA00006534}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP002171; ADL70183.1; -; Genomic_DNA.
DR   RefSeq; WP_013299137.1; NC_014410.1.
DR   AlphaFoldDB; D9TRH5; -.
DR   STRING; 580327.Tthe_2741; -.
DR   MEROPS; S51.003; -.
DR   KEGG; ttm:Tthe_2741; -.
DR   eggNOG; COG4242; Bacteria.
DR   HOGENOM; CLU_053928_0_0_9; -.
DR   OrthoDB; 9799980at2; -.
DR   Proteomes; UP000001626; Chromosome.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd03145; GAT1_cyanophycinase; 1.
DR   Gene3D; 3.40.50.880; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR005320; Peptidase_S51.
DR   InterPro; IPR011811; Peptidase_S51_cyanophycinase.
DR   NCBIfam; TIGR02069; cyanophycinase; 1.
DR   PANTHER; PTHR36175; CYANOPHYCINASE; 1.
DR   PANTHER; PTHR36175:SF1; CYANOPHYCINASE; 1.
DR   Pfam; PF03575; Peptidase_S51; 1.
DR   PIRSF; PIRSF032067; Cyanophycinase; 1.
DR   SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000313|EMBL:ADL70183.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ADL70183.1};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001626};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT   ACT_SITE        132
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR032067-1"
FT   ACT_SITE        174
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR032067-1"
FT   ACT_SITE        201
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR032067-1"
SQ   SEQUENCE   273 AA;  29779 MW;  E8EEBDA75E1E7E9D CRC64;
     MDEINRGKLL IIGGAEDKKD KCIILKEVIK LSGGENSRIV IMTTATEKPE EVGKNYVEIF
     KRLGAVTVET VNIDSRDDVK NEIVKERLRN STCIFFTGGD QLRITSILGG SGIDKLLNEL
     NKRKGILVVG TSAGASVMSR TMIIGGNDEE SPRKCTINMA PGLGLLNNVI IDQHFAQRGR
     IGRLLTAIAE NPENLGVGID EDTAIVVDGN KFRVIGSNAV TVVDGRTLKN TNVSESSPDE
     ILSLTHVTLH ILPSGYGFDI MLREPFKYNK EDK
//
DBGET integrated database retrieval system