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Database: UniProt
Entry: D9V382_9ACTN
LinkDB: D9V382_9ACTN
Original site: D9V382_9ACTN 
ID   D9V382_9ACTN            Unreviewed;       464 AA.
AC   D9V382;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   28-FEB-2018, entry version 37.
DE   SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:EFL11285.1};
GN   ORFNames=SSMG_06956 {ECO:0000313|EMBL:EFL11285.1};
OS   Streptomyces sp. AA4.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=591158 {ECO:0000313|EMBL:EFL11285.1, ECO:0000313|Proteomes:UP000003970};
RN   [1] {ECO:0000313|EMBL:EFL11285.1, ECO:0000313|Proteomes:UP000003970}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AA4 {ECO:0000313|EMBL:EFL11285.1,
RC   ECO:0000313|Proteomes:UP000003970};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C.,
RA   Sykes S.N., Thomson T., Walk T., White J., Yandava C., Straight P.,
RA   Clardy J., Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T.,
RA   Wieland-Brown L.C., Haas B., Nusbaum C., Birren B.;
RT   "Annotation of Streptomyces sp. strain AA4.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
CC       {ECO:0000256|RuleBase:RU003427}.
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DR   EMBL; GG657746; EFL11285.1; -; Genomic_DNA.
DR   RefSeq; WP_009083946.1; NZ_GG657746.1.
DR   ProteinModelPortal; D9V382; -.
DR   STRING; 591158.SSMG_06956; -.
DR   EnsemblBacteria; EFL11285; EFL11285; SSMG_06956.
DR   eggNOG; ENOG4105C6K; Bacteria.
DR   eggNOG; COG0281; LUCA.
DR   OrthoDB; POG091H02AU; -.
DR   Proteomes; UP000003970; Unassembled WGS sequence.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000003970};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3,
KW   ECO:0000256|RuleBase:RU003427};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003970}.
FT   DOMAIN       92    225       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      237    459       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   ACT_SITE    113    113       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE    168    168       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       210    210       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       211    211       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       236    236       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   464 AA;  48654 MW;  FADEF7B7BA40A1ED CRC64;
     MPVPGPGYSI TVRVEAPASS TAAGDLTTAV GRVGGVLTAF DVVESHADMI VVDISANALS
     ENHAQDITQA LDSLPGVQVR KVSDRTFLIH LGGKIEVSPK VALRNRDDLS RAYTPGVARV
     CQAIAANPED ARRLTIKRNT VAVLTDGSAV LGLGNIGPAA ALPVMEGKAA LFKKFAGVDA
     WPVCLDTQDT EEIIMIAKAL APVYAGINLE DIAAPRCFEI EKRLREQLDI PVFHDDQHGT
     AIVVVAALRN ALRVVGKNIE DCKIVVSGVG AAGSAIIRLL LRKNPGDIVA ADIDGIVYPE
     RGNLDDNLTW IAEHTNKDGK SGTLHDALVG ADVFIGVSAP NLFGAEQVAK MNDDAVVFAL
     ANPDPEIDPL EAQKHAAVVA TGRSDFPNQI NNVLAFPGVF RGLLDAAAHN IDDNMLLAAS
     DAIADVVDNG KLNASFIVPS VFDSAVAPAV AEAVRNAVRA ERAS
//
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