ID D9W5N9_9ACTN Unreviewed; 1248 AA.
AC D9W5N9;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Lasalocid modular polyketide synthase {ECO:0000313|EMBL:EFL20217.1};
GN ORFNames=SSNG_07469 {ECO:0000313|EMBL:EFL20217.1};
OS Streptomyces sp. C.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=253839 {ECO:0000313|EMBL:EFL20217.1, ECO:0000313|Proteomes:UP000005763};
RN [1] {ECO:0000313|EMBL:EFL20217.1, ECO:0000313|Proteomes:UP000005763}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C {ECO:0000313|EMBL:EFL20217.1,
RC ECO:0000313|Proteomes:UP000005763};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "Annotation of Streptomyces sp. strain C.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; GG657752; EFL20217.1; -; Genomic_DNA.
DR AlphaFoldDB; D9W5N9; -.
DR STRING; 253839.SSNG_07469; -.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_35_2_11; -.
DR Proteomes; UP000005763; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1088..1168
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1248 AA; 131045 MW; FBBEBC7AFA268954 CRC64;
MLPKTLHADE PSPHIDWSSG GVRLLNESRD WTRRGEEPRR AGVSSFGVSG TNAHVILEEA
APADLPAAPS PEDGGAPVPW ILSGRTRAAL REQAARLLDH VRDGAAPAST GFSLATTRTA
HPVRGAVVAA KHEEFLAGLA ELAEGDTTGV TAAAGADRPV FVFPGQGSQW AGMAVELYDS
SPVFAARLEE CAQALAPHTD WSLLDVLRQK DGAPGFDRVD VVQPALWAVM VSLAELWRFH
GVRPAAVLGH SQGEIAAAAV SGALSLQDAA KVSALRAKAI VALAGKGGMV SVADVADAVA
ERISAWGDRL ALASVNGPRS TVVSGDPEAL DELLAACEAD GVRARRINVD YASHSAQVES
IRDEVIGLLT GIEPRTAEVP FFSTVTGEWA DGSELDAEYW YTNLRTTVRF EDGVRSLLAS
GHGLFVEASA HPVLTIGVQE TIDAADAPAA ASAVTLATLR RDEGGPQRFL TSLAEAWTRG
ATVAWPTVFP EGAQRVDLPT YAFQHRPYWL DAAPADPAAP APAAHGGDET DAAFWAAVDS
GDLAPLGVGA DQPLGEALPA LAAWRRTRRE KSAIDSWRYR TVWTVAETAA PQLTGTWLIV
ESEGGDDALA AAAADRLAAQ GARTVRIPVD VWAADRYTLA QQLHQELTAE GEDRVTGILS
LLSLDERPHP DHPELPLGLA GTVTLVQAVL QVRELAEFDA PLWALTQGAV SVGDSDPLTS
PVQATVWGLA RVLVQEHPRL WGGIVDLPQQ PDEEAWKRLA GILTEPGDED QLAVRSWNVL
VRRLVRAPLG DTEPARTWQP TGTALITGGT GGLGAQTARW LARAGAEHLL LISRSGPDAP
GADALHAELT ALGARVTIAA ADVSDATALA AAIDALPADA PLTSVFHTAA VLDDGMVDSL
TPDRMERVLA VKARGALNLQ ELTRDKELTA FVLFSSFGAA YGSAGLGNYT PGNTFLDALA
EQRRALGLPA TAVVWGTWEG SGMADNGVGE RARLQGVWEL PPELATAALQ QSLDHEETSP
VIIDIRWDSF SLGTNTERDS PLFEMVPEAA KLLAQAEATA AAEAEAADGA ADALLHRLTG
LPPAEQDRVL LDLVRKQAAS VLGHGTAGPE ALAAVGPQRA FRELGFDSLS AVELRNRLGT
ATGLSLPSTL VFDHPTPVEL AALLRTELLG DTDGVDPLLD EIDRLGGALA AAAQAGPEDR
GRISGRLHAL LAAWNATGAD AAPAPDADLD AASDSELFDL LDDELETQ
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