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Database: UniProt
Entry: D9WG11_9ACTN
LinkDB: D9WG11_9ACTN
Original site: D9WG11_9ACTN 
ID   D9WG11_9ACTN            Unreviewed;       880 AA.
AC   D9WG11;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   SubName: Full=Modular polyketide synthase {ECO:0000313|EMBL:EFL23227.1};
DE   Flags: Fragment;
GN   ORFNames=SSOG_02941 {ECO:0000313|EMBL:EFL23227.1};
OS   Streptomyces himastatinicus ATCC 53653.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
OX   NCBI_TaxID=457427 {ECO:0000313|EMBL:EFL23227.1, ECO:0000313|Proteomes:UP000003963};
RN   [1] {ECO:0000313|EMBL:EFL23227.1, ECO:0000313|Proteomes:UP000003963}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 53653 {ECO:0000313|EMBL:EFL23227.1,
RC   ECO:0000313|Proteomes:UP000003963};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA   Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA   Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA   Haas B., Nusbaum C., Birren B.;
RT   "Annotation of Streptomyces hygroscopicus strain ATCC 53653.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GG657754; EFL23227.1; -; Genomic_DNA.
DR   AlphaFoldDB; D9WG11; -.
DR   STRING; 457427.SSOG_02941; -.
DR   HOGENOM; CLU_000022_16_6_11; -.
DR   OrthoDB; 9778690at2; -.
DR   Proteomes; UP000003963; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR036299; Polyketide_synth_docking_sf.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF101173; Docking domain B of the erythromycin polyketide synthase (DEBS); 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW   Transferase {ECO:0000256|ARBA:ARBA00023315}.
FT   DOMAIN          33..462
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   NON_TER         880
FT                   /evidence="ECO:0000313|EMBL:EFL23227.1"
SQ   SEQUENCE   880 AA;  91820 MW;  874B4BCA67C1E3E9 CRC64;
     MANEEKLRAY LKRVTGDLHQ ARQRLQQLED GSAEPIAITA MSCRYPGGVE SPAELWNLVA
     SGVDAVSGFP TNRGWDLDDL FDSDPDAKGK SYAREGGFLR DADQFDPAFF GISPREAMTM
     DPQQRLLLET AWEALERAGI EPDSLRGSRT GVFAGVMYDD YGAARIYGGS ADEFEGYLVN
     GSAGSIASGR VAYTLGLEGP AVTVDTACSS SLVSLHLAVQ ALRAGECSMA LAGGVTVLAT
     PSLFVEFSRQ RGLSPDGRCR SFSDDADGTG WSEGAGMLLL ERLSDAQANG HPVLAVVRGS
     AVNQDGASNG LTAPNGPSQQ RVIRAALANA RMSEAEVDAV EAHGTGTTLG DPIEAQALIA
     TYGQGRAEGQ PLWLGSLKSN IGHAQAAAGV AGVIKMVEAM RHGVLPQTLH VGEPSSKVDW
     DAGAVELLSE ARAWPEAEGR PRRAGVSAFG ASGTNAHVIL EQAPAVEPTS DAGDAVAAGV
     VPWVVSGRGA DALRGQAARL LSRAEGDGGL APVDVGWSLA SGRAALEDRA VVVAPDREGL
     IAGLGGLARG ESVPGLVTGS VVEGRVAFLF TGQGSQRLGM GRALYDAHPV FADALDEVCA
     ELDRHLERPL KGVLFGEDAS VLDRTGFTQP ALFAVEVALF RLVQAWGVRP DFLSGHSIGE
     LAAAHVAGVL SLADACTLVA ARGRLMQELP AGGAMVAVQA SEFEVAPLLT ERVSIAAVND
     PTSVVISGDE DAVLELASGF AAQGRKTKRL AVSHAFHSPR MDGMLDAFRE VAEGLTYEAP
     RIPIVSNLTG ELVSAEEIAT PGFWVRHARE AVRFLDGVRA LEAQGVTTYV ELGPDGVLTA
     MAQECVTGDD AAFVPVLRAD RAEEQAFVEG VARAWTVGVA
//
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