ID D9WJP1_9ACTN Unreviewed; 524 AA.
AC D9WJP1;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 {ECO:0000256|ARBA:ARBA00040298};
GN ORFNames=SSOG_01181 {ECO:0000313|EMBL:EFL21469.1};
OS Streptomyces himastatinicus ATCC 53653.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
OX NCBI_TaxID=457427 {ECO:0000313|EMBL:EFL21469.1, ECO:0000313|Proteomes:UP000003963};
RN [1] {ECO:0000313|EMBL:EFL21469.1, ECO:0000313|Proteomes:UP000003963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53653 {ECO:0000313|EMBL:EFL21469.1,
RC ECO:0000313|Proteomes:UP000003963};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "Annotation of Streptomyces hygroscopicus strain ATCC 53653.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable oxidoreductase that may play a role as regulator of
CC mitochondrial function. {ECO:0000256|ARBA:ARBA00037217}.
CC -!- SUBUNIT: Interacts with COX5B; this interaction may contribute to
CC localize PYROXD2 to the inner face of the inner mitochondrial membrane.
CC {ECO:0000256|ARBA:ARBA00038825}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|ARBA:ARBA00004305}.
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DR EMBL; GG657754; EFL21469.1; -; Genomic_DNA.
DR RefSeq; WP_009713291.1; NZ_GG657754.1.
DR AlphaFoldDB; D9WJP1; -.
DR STRING; 457427.SSOG_01181; -.
DR HOGENOM; CLU_019327_0_1_11; -.
DR OrthoDB; 9774675at2; -.
DR Proteomes; UP000003963; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR PANTHER; PTHR10668; PHYTOENE DEHYDROGENASE; 1.
DR PANTHER; PTHR10668:SF103; PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
FT DOMAIN 25..312
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 524 AA; 55383 MW; B8ADEA45C09B750A CRC64;
MPHSDASDAS DAYDVVIVGG GHNALVAAAY LGRAGRSVRV LERLGHTGGA AVSTRPFAGV
DARLSRYSYL VSLLPGRIVD DLGLRFAVRK RSVSSYTPTV RGGRPTGLLV ETGGGARTRE
AFARLTGGER EYAAWERFYA MTGRVAERVF PTLTEPLPDR AALRARIGDD VAWETLFERP
LGEAVEAAFE DDLVRGVVLT DALIGTFASA HDPSLAQNRC FLYHVIGGGT GDWDVPVGGM
GAFTDALAHA ASLAGARIAT GCEVTGIVTD GTSAEVAYVD QDGEHVVGAR HVLVGAAPRE
LARLLGEEPP APPAEGAQLK VNMLLRRLPA LRDPGADPRE AFAGTFHIAE GYGDLEAAYR
QAAAGELPRR PPSEIYCHSL TDPSILGPDL AARGYQTLTL FGLHTPARLF ADDPEGTREA
LLRDTLAQLD AHLAEPIADC LAYDADGRPC IEAKSPLDLD RELRLPGGNI FHRELAFPYA
QEGTGRWGVE TRHANVLLCG AGAVRGGGVS GIPGHNAAMA VLGK
//
