ID D9X7U4_STRVT Unreviewed; 721 AA.
AC D9X7U4;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Formate dehydrogenase, alpha subunit {ECO:0000313|EMBL:EFL31952.1};
GN ORFNames=SSQG_02470 {ECO:0000313|EMBL:EFL31952.1};
OS Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 /
OS Tue 494).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=591159 {ECO:0000313|EMBL:EFL31952.1, ECO:0000313|Proteomes:UP000004184};
RN [1] {ECO:0000313|Proteomes:UP000004184}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494
RC {ECO:0000313|Proteomes:UP000004184};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "Annotation of Streptomyces viridochromogenes strain DSM 40736.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; GG657757; EFL31952.1; -; Genomic_DNA.
DR AlphaFoldDB; D9X7U4; -.
DR STRING; 591159.SSQG_02470; -.
DR eggNOG; COG0243; Bacteria.
DR HOGENOM; CLU_000422_13_4_11; -.
DR Proteomes; UP000004184; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR PANTHER; PTHR43105:SF15; FORMATE DEHYDROGENASE H; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000004184}.
FT DOMAIN 3..59
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
FT REGION 534..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 721 AA; 76229 MW; D393895674B9C266 CRC64;
MQTTATPTHC PYCALQCGMN LTPAPDGTVE VSERADFPVN RGALCGKGRT APAVLASNVR
LTSPLVRSGD ALVPASWDEA LDRIAAGLRR TREEYGPDGV GVFGGGGLTN EKAYTLGKFA
RVVLGTSQID YNGRFCMSSA AAAGIKAFGL DRGLPFPLED VPKTGCVILV GSNLAETMPP
SLRFLTELKE NGGTLIVIDP RRTKTAEQAD LHLAPRPGTD LALALGLLHL VIAEGRVDEE
YVQERTVGWE DARAAAMAHW PEHVERITGV SVPELRETVR LFCEPESAMV LTARGPEQQS
KGTDTVGAWI NLCLATGRAG RPLSGYGCLT GQGNGQGGRE HGQKADQLPG YRKLDDPAAR
RHVAEVWGVD PDSLPGPGRS AYELLDALGT DIRSLLLMAS NPVVSAPRAA HVEERIRSLD
FLAVCDVVLS ETAALADVVL PVTQWAEETG TTTNLEGRVL LRRRAITPPD GVRTDLEVLH
ELAARLGVEK GFPTDPEEVF EELRRASAGG AADYSGITYG RLAEEDGVFW PCPTMETEEP
TSRPFLATES ADSAPGRTKA APAEAAGGPA GSACAAGGGP GAQESAPDRP AVTTYHPATT
TDPTSHPATK LGTTSRPDAA GDPTGPGRPV HPGTPRLFLD RFATPDGRAR FVPVSHRATA
EEPDDEYPVL LTTGRVVAQY QSGAQTRRVA ELNAAAPGPF VELHPRLAAR LGGARGANRW
T
//
