ID D9XGD5_STRVT Unreviewed; 605 AA.
AC D9XGD5;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Thioredoxin reductase {ECO:0000313|EMBL:EFL37024.1};
GN ORFNames=SSQG_07542 {ECO:0000313|EMBL:EFL37024.1};
OS Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 /
OS Tue 494).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=591159 {ECO:0000313|EMBL:EFL37024.1, ECO:0000313|Proteomes:UP000004184};
RN [1] {ECO:0000313|Proteomes:UP000004184}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494
RC {ECO:0000313|Proteomes:UP000004184};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "Annotation of Streptomyces viridochromogenes strain DSM 40736.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide +
CC H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA-
CC COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000849};
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DR EMBL; GG657757; EFL37024.1; -; Genomic_DNA.
DR AlphaFoldDB; D9XGD5; -.
DR STRING; 591159.SSQG_07542; -.
DR eggNOG; COG0492; Bacteria.
DR HOGENOM; CLU_031864_5_8_11; -.
DR Proteomes; UP000004184; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR48105:SF5; BLR1248 PROTEIN; 1.
DR PANTHER; PTHR48105; THIOREDOXIN REDUCTASE 1-RELATED-RELATED; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00469; PNDRDTASEII.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 43..146
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 12..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 605 AA; 64684 MW; BB0B71D74BAA4299 CRC64;
MAVVLRPRGV RVMPGDETRP GAAQVPDETE ESVPFETADI YGAYPRLPED QIDRLAQRGR
RRAVDAGDVL IQEGERCETF YVVLSGSVAI VEGYGTPDER LLRVHGPGRF IGELGLLNGQ
VAFYTAVIRD PGEVLAVSMD QLRDLVARDS VLGDLVLRAC LGRRALLVGQ GAGFRIVGSR
YSPDTRRLRE FAARNRLPYR WIDLETDEEA EELLRRFGVG PEETPIVIWR DTTLLRNPSN
AELARLIGLP SLPAGNHHGD LLIVGSGPAG LAAAVNAASE GLGTTLVEAM ATGGQAGTSS
RIENLLGFPS GISGAELTDR AVLQADKFGA RISVPAEAAR LEPRDGHYAV GFADGSEITA
RSVVLATGAR YRRLHVPGIE RLEGTSVHYS ATVYEAQQCR TDPVAVVGGG NSAGQAVLFL
AGYAPQVYLL VRGPSLEAHM SRYLIDQVER HPRVRVLLHT EMTEALGDKV LEAVTVVDHR
TGEHRQLAVR ALFVFTGADP HTGWLSGALA LDARGFVLTG AEAQACSVPG LWQSQGRDCL
TLETSLPGVF AAGDVRSGSV KRVASAVGEG AMSIHFVHRS LNHSAAPGGS DSAPHTRPKE
SAWLA
//