ID   D9XV34_9ACTN            Unreviewed;       409 AA.
AC   D9XV34;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=Macrolide glycosyltransferase {ECO:0000313|EMBL:EFL38312.1};
GN   ORFNames=SSRG_01116 {ECO:0000313|EMBL:EFL38312.1};
OS   Streptomyces griseoflavus Tu4000.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=467200 {ECO:0000313|EMBL:EFL38312.1, ECO:0000313|Proteomes:UP000002968};
RN   [1] {ECO:0000313|EMBL:EFL38312.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tu4000 {ECO:0000313|EMBL:EFL38312.1};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA   Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA   Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA   Haas B., Nusbaum C., Birren B.;
RT   "Annotation of Streptomyces griseoflavus strain Tu4000.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009995}.
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DR   EMBL; GG657758; EFL38312.1; -; Genomic_DNA.
DR   AlphaFoldDB; D9XV34; -.
DR   STRING; 467200.SSRG_01116; -.
DR   eggNOG; COG1819; Bacteria.
DR   HOGENOM; CLU_000537_7_1_11; -.
DR   Proteomes; UP000002968; Unassembled WGS sequence.
DR   GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   InterPro; IPR010610; EryCIII-like_C.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   InterPro; IPR006326; UDPGT_MGT-like.
DR   NCBIfam; TIGR01426; MGT; 1.
DR   PANTHER; PTHR48050; STEROL 3-BETA-GLUCOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR48050:SF13; UDP-GLUCURONOSYLTRANSFERASE; 1.
DR   Pfam; PF06722; EryCIII-like_C; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Transferase {ECO:0000313|EMBL:EFL38312.1}.
FT   DOMAIN          285..393
FT                   /note="Erythromycin biosynthesis protein CIII-like C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06722"
SQ   SEQUENCE   409 AA;  44243 MW;  E33215A62A8FAE7F CRC64;
     MHETSRLAYG RGMTSPAHIA MFSIAAHGHV NPSLEVIREL VARGHRVTYA IPPHFAEKIA
     GTGAEPVLWN STLPGPDDDP EAWGSTLLDN MEPFLADAVQ ALPQLIEAYE GDTPDLVLHD
     ITSYPARVLA HRWGVPAVSL SPNLVAWDGY EKEVAEPMWE EPKKTERGQA YYARFRAWLE
     ENGITQHPDD FVGRPARSIV LIPRALQPHA DRVDERVHSF VGACQGDRGA EGGWHRPAGA
     EKVVLVSLGS SFTKQPAFYR ECVEAFGGLP GWHLVLQIGR RVDPAELGDL PDNVEVRSWV
     PQLAILRQAD LFVTHAGAGG SQEGLATATP MIAVPQAVDQ FGNADMLQGL GVARHVPAGE
     ADAGTLRAAA LALVDDPEVA RRLKGIQAQM AEEGGTRRAA DLIEAELQA
//