ID D9XYU6_9ACTN Unreviewed; 521 AA.
AC D9XYU6;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Drug resistance transporter {ECO:0000313|EMBL:EFL38924.1};
GN ORFNames=SSRG_01728 {ECO:0000313|EMBL:EFL38924.1};
OS Streptomyces griseoflavus Tu4000.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=467200 {ECO:0000313|EMBL:EFL38924.1, ECO:0000313|Proteomes:UP000002968};
RN [1] {ECO:0000313|EMBL:EFL38924.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tu4000 {ECO:0000313|EMBL:EFL38924.1};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "Annotation of Streptomyces griseoflavus strain Tu4000.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG657758; EFL38924.1; -; Genomic_DNA.
DR AlphaFoldDB; D9XYU6; -.
DR eggNOG; COG0477; Bacteria.
DR HOGENOM; CLU_000960_28_2_11; -.
DR OrthoDB; 9781469at2; -.
DR Proteomes; UP000002968; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd17321; MFS_MMR_MDR_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR42718:SF42; INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED; 1.
DR PANTHER; PTHR42718; MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC; 1.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR00173; EDTRNSPORT.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..458
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 521 AA; 53386 MW; A44C26AF7F1ACDA1 CRC64;
MRTVSGMTTN PHRAGRREWT ALSVLMLPLL LVSMDVSVLY FAIPEISADL EPSGTQQLWI
FDIYGFVLAG LLMTMGAVGD RVGRRRLLLV GAAAFGAASL LAAYAHSAET LIAARAVLGV
GGATLMPSTM ALVRTMFTDP AQRAKAIGLW SGVMTAGIAL GSVMSGVLVE HFWWGSVFLV
NLPAMALLLA LGPVLLPESK NPSPGRFDLL SVPLSMAAVL PVVYGLKELP SEGWNVRYVM
AITVGLLFAA LFVHRQRTTA SPMIPPALFR GHGFSPALVL NTVSAFGMMG SAFFTTQYLQ
SVLGKSALEA ALWSLLPSVL IGAAAPAAAL LVQRGAERAY VVTAGFVIAA CGYGLLALAG
TDSLWPVLTA CGVMASGIVI VMSLLTDLAL SSAPVEQAGS ASSLLETGTE FGGALGMAAL
GSIGTAVYRH QIPDAAPAAA RETLGGALTV AAELPGRAGD ALATAAREAF TSGMQGAAVA
GVVVLLGAGG LAAVGLRHIR IRPEAPTENA GQADALSPSG V
//
