ID D9ZHC9_HYPPE Unreviewed; 239 AA.
AC D9ZHC9;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 03-MAY-2023, entry version 30.
DE RecName: Full=Thymidine kinase {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544};
DE EC=2.7.1.21 {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544};
GN Name=TK {ECO:0000313|EMBL:ADK92870.1};
OS Hypericum perforatum (St. John's wort).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Hypericaceae; Hypericeae; Hypericum.
OX NCBI_TaxID=65561 {ECO:0000313|EMBL:ADK92870.1};
RN [1] {ECO:0000313|EMBL:ADK92870.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20202173; DOI=10.1111/j.1365-313X.2010.04188.x;
RA Schallau A., Arzenton F., Johnston A.J., Hahnel U., Koszegi D.,
RA Blattner F.R., Altschmied L., Haberer G., Barcaccia G., Baumlein H.;
RT "Identification and genetic analysis of the APOSPORY locus in Hypericum
RT perforatum L.";
RL Plant J. 62:773-784(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.1.21;
CC Evidence={ECO:0000256|RuleBase:RU000544};
CC -!- SIMILARITY: Belongs to the thymidine kinase family.
CC {ECO:0000256|ARBA:ARBA00007587, ECO:0000256|RuleBase:RU004165}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HM061166; ADK92870.1; -; Genomic_DNA.
DR AlphaFoldDB; D9ZHC9; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001267; Thymidine_kinase.
DR InterPro; IPR020633; Thymidine_kinase_CS.
DR PANTHER; PTHR11441; THYMIDINE KINASE; 1.
DR PANTHER; PTHR11441:SF0; THYMIDINE KINASE, CYTOSOLIC; 1.
DR Pfam; PF00265; TK; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000544};
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634,
KW ECO:0000256|RuleBase:RU000544};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU000544};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000544};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000544}.
SQ SEQUENCE 239 AA; 25933 MW; 0690F5A8C139D927 CRC64;
MASSSSSAAA KILVPRRAHG EIHVIIGPMF AGKTTALLRR ITSESDGGRK VAMIKSSKDN
RYAVDSVVTH DGLKFPCWAL SDLSSFNLRL GHEAYDSIDV IGIDEAQFFD DLYDFCCTAA
DRDGKIVVVA GLDGDYLRKR FGSVLDVVPL ADTVTKLTAR CELCGKRAFF TFRKTSETRT
ELVAGADVYM PVCREHYISG QVVMDAARSV AKLPDVVVAS SPTSVLESHK VHEVAAPVM
//
