ID DCAF8_XENTR Reviewed; 604 AA.
AC Q28I90;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=DDB1- and CUL4-associated factor 8;
DE AltName: Full=WD repeat-containing protein 42A;
GN Name=dcaf8; Synonyms=wdr42a; ORFNames=TEgg075a15.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tadpole;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5TAQ9}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q5TAQ9}. Note=It shuttles between the nucleus
CC and the cytoplasm. {ECO:0000250|UniProtKB:Q5TAQ9}.
CC -!- SIMILARITY: Belongs to the WD repeat DCAF8 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR760529; CAJ81403.1; -; mRNA.
DR EMBL; BC135344; AAI35345.1; -; mRNA.
DR RefSeq; NP_001016610.1; NM_001016610.1.
DR RefSeq; XP_017951752.1; XM_018096263.1.
DR AlphaFoldDB; Q28I90; -.
DR SMR; Q28I90; -.
DR STRING; 8364.ENSXETP00000025350; -.
DR PaxDb; 8364-ENSXETP00000017785; -.
DR DNASU; 549364; -.
DR GeneID; 549364; -.
DR KEGG; xtr:549364; -.
DR AGR; Xenbase:XB-GENE-989771; -.
DR CTD; 50717; -.
DR Xenbase; XB-GENE-989771; dcaf8.
DR eggNOG; KOG1334; Eukaryota.
DR InParanoid; Q28I90; -.
DR OMA; ATQCCKT; -.
DR OrthoDB; 66220at2759; -.
DR Proteomes; UP000008143; Chromosome 8.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045151; DCAF8.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15574:SF21; DDB1- AND CUL4-ASSOCIATED FACTOR 8; 1.
DR PANTHER; PTHR15574; WD REPEAT DOMAIN-CONTAINING FAMILY; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..604
FT /note="DDB1- and CUL4-associated factor 8"
FT /id="PRO_0000296961"
FT REPEAT 197..236
FT /note="WD 1"
FT REPEAT 240..281
FT /note="WD 2"
FT REPEAT 287..327
FT /note="WD 3"
FT REPEAT 335..375
FT /note="WD 4"
FT REPEAT 391..430
FT /note="WD 5"
FT REPEAT 438..478
FT /note="WD 6"
FT REPEAT 482..522
FT /note="WD 7"
FT REGION 1..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 39..50
FT /note="Nuclear export signal"
FT /evidence="ECO:0000250|UniProtKB:Q5TAQ9"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..114
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 604 AA; 67794 MW; 6F66D2CA4F00D59D CRC64;
MSFSGEMANG KTDVANSGFS SSPEDMSGAE EGKENSSGIE VEASDVSLSL TGDETGTTQA
ESRDTCSETS GEDKDSDSMD DTGHYSINDE NRGNDQSHSE DEEEEEEEEE DEEEEEAVRH
RKRAQRKRAN RDQDSSDEER ALEDWVLSEK TPLPRPRWRA LRALRQRQMG SSTRFIYDAC
GARGFVQRFR LLHGLDGHSG CVNTLHFNQR GTWLASGSDD LKVVVWDWVR RKPVLEFESG
HKSNVFQAKF LPNSGDSTLA MCARDGQVRV AELSATHCCK NTKRVAQHKG ASHKLALERD
SPCTFLSAGE DAVVFTIDLR QDRPASRLVV TKEKEKKVGL YTIYVNPANT YQFAVGGRDQ
FVRIYDQRKI NENVNNGVLK KFCPHHLVTS EAKANITCLV YSHDGSELLA SYNDEDIYLF
NSSHSDGAEY IKRYKGHRNN ATVKGVNFYG PRSEFVVSGS DCGHIFLWEK SSCQIVQFMD
GDKGGVVNCL EPHPHLPVLA TSGLDYDVKI WLPTAKEPTE LNGLKEVIKK NKRERDEDSL
HHTDLFDNHM LWFLMHHLRQ RGQRRRRRDA GLGAGDADSD DSPSSSDSSD DDEDGPDRVQ
CIPS
//
