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Database: UniProt
Entry: DENR_DANRE
LinkDB: DENR_DANRE
Original site: DENR_DANRE 
ID   DENR_DANRE              Reviewed;         208 AA.
AC   Q6DH65;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   30-AUG-2017, entry version 67.
DE   RecName: Full=Density-regulated protein;
DE            Short=DRP;
GN   Name=denr; ORFNames=zgc:92629;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Liver;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18307296; DOI=10.1021/pr700667w;
RA   Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B.,
RA   den Hertog J., Slijper M., Heck A.J.R.;
RT   "Online automated in vivo zebrafish phosphoproteomics: from large-
RT   scale analysis down to a single embryo.";
RL   J. Proteome Res. 7:1555-1564(2008).
CC   -!- FUNCTION: May be involved in the translation of target mRNAs by
CC       scanning and recognition of the initiation codon. Involved in
CC       translation initiation; promotes recruitment of aminoacetyled
CC       initiator tRNA to P site of 40S ribosomes. Can promote release of
CC       deacylated tRNA and mRNA from recycled 40S subunits following
CC       ABCE1-mediated dissociation of post-termination ribosomal
CC       complexes into subunits (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DENR family. {ECO:0000305}.
DR   EMBL; BC076117; AAH76117.1; -; mRNA.
DR   EMBL; BC095896; AAH95896.1; -; mRNA.
DR   RefSeq; NP_001002697.1; NM_001002697.2.
DR   UniGene; Dr.11982; -.
DR   ProteinModelPortal; Q6DH65; -.
DR   SMR; Q6DH65; -.
DR   STRING; 7955.ENSDARP00000054152; -.
DR   iPTMnet; Q6DH65; -.
DR   PaxDb; Q6DH65; -.
DR   PRIDE; Q6DH65; -.
DR   Ensembl; ENSDART00000054153; ENSDARP00000054152; ENSDARG00000037229.
DR   GeneID; 436970; -.
DR   KEGG; dre:436970; -.
DR   CTD; 8562; -.
DR   ZFIN; ZDB-GENE-040718-450; denr.
DR   eggNOG; KOG3239; Eukaryota.
DR   eggNOG; COG0023; LUCA.
DR   GeneTree; ENSGT00390000014349; -.
DR   HOGENOM; HOG000237611; -.
DR   HOVERGEN; HBG005471; -.
DR   InParanoid; Q6DH65; -.
DR   OMA; SGGHDCK; -.
DR   OrthoDB; EOG091G0R9X; -.
DR   PhylomeDB; Q6DH65; -.
DR   TreeFam; TF105912; -.
DR   PRO; PR:Q6DH65; -.
DR   Proteomes; UP000000437; Chromosome 10.
DR   Bgee; ENSDARG00000037229; -.
DR   GO; GO:0070992; C:translation initiation complex; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR   GO; GO:0002192; P:IRES-dependent translational initiation of linear mRNA; IBA:GO_Central.
DR   GO; GO:0002188; P:translation reinitiation; IBA:GO_Central.
DR   Gene3D; 3.30.780.10; -; 1.
DR   InterPro; IPR005873; Drp1.
DR   InterPro; IPR001950; SUI1.
DR   InterPro; IPR005872; SUI1_arc_bac.
DR   PANTHER; PTHR12789; PTHR12789; 1.
DR   Pfam; PF01253; SUI1; 1.
DR   SUPFAM; SSF55159; SSF55159; 2.
DR   TIGRFAMs; TIGR01159; DRP1; 1.
DR   PROSITE; PS50296; SUI1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Initiation factor; Phosphoprotein;
KW   Protein biosynthesis; Reference proteome.
FT   CHAIN         1    208       Density-regulated protein.
FT                                /FTId=PRO_0000130604.
FT   DOMAIN      125    192       SUI1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00200}.
FT   MOD_RES       9      9       Phosphoserine.
FT                                {ECO:0000269|PubMed:18307296}.
SQ   SEQUENCE   208 AA;  22804 MW;  8AD1E48F5E7F9D53 CRC64;
     MATTENAESG SPENKVDRAD PDAKYPLKVL YCGVCSLPAE YCEYMPEPAK CKQWLEKNFP
     DVFAKLTLGT APKQESKGGG GGEDGGGGRG RGEAPPAGEE EEKKKQKRGG RGQIKQKKKT
     VPQKVTIAKI PRAKKKYVTR VCGLATFDIE LKEAQRFFAQ KFSCGASVTA EDEIIIQGDF
     TDDIIDVIQE KWPEVDDDSI DDLGEVKK
//
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