ID DENR_DANRE Reviewed; 208 AA.
AC Q6DH65;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 30-AUG-2017, entry version 67.
DE RecName: Full=Density-regulated protein;
DE Short=DRP;
GN Name=denr; ORFNames=zgc:92629;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo, and Liver;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18307296; DOI=10.1021/pr700667w;
RA Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B.,
RA den Hertog J., Slijper M., Heck A.J.R.;
RT "Online automated in vivo zebrafish phosphoproteomics: from large-
RT scale analysis down to a single embryo.";
RL J. Proteome Res. 7:1555-1564(2008).
CC -!- FUNCTION: May be involved in the translation of target mRNAs by
CC scanning and recognition of the initiation codon. Involved in
CC translation initiation; promotes recruitment of aminoacetyled
CC initiator tRNA to P site of 40S ribosomes. Can promote release of
CC deacylated tRNA and mRNA from recycled 40S subunits following
CC ABCE1-mediated dissociation of post-termination ribosomal
CC complexes into subunits (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DENR family. {ECO:0000305}.
DR EMBL; BC076117; AAH76117.1; -; mRNA.
DR EMBL; BC095896; AAH95896.1; -; mRNA.
DR RefSeq; NP_001002697.1; NM_001002697.2.
DR UniGene; Dr.11982; -.
DR ProteinModelPortal; Q6DH65; -.
DR SMR; Q6DH65; -.
DR STRING; 7955.ENSDARP00000054152; -.
DR iPTMnet; Q6DH65; -.
DR PaxDb; Q6DH65; -.
DR PRIDE; Q6DH65; -.
DR Ensembl; ENSDART00000054153; ENSDARP00000054152; ENSDARG00000037229.
DR GeneID; 436970; -.
DR KEGG; dre:436970; -.
DR CTD; 8562; -.
DR ZFIN; ZDB-GENE-040718-450; denr.
DR eggNOG; KOG3239; Eukaryota.
DR eggNOG; COG0023; LUCA.
DR GeneTree; ENSGT00390000014349; -.
DR HOGENOM; HOG000237611; -.
DR HOVERGEN; HBG005471; -.
DR InParanoid; Q6DH65; -.
DR OMA; SGGHDCK; -.
DR OrthoDB; EOG091G0R9X; -.
DR PhylomeDB; Q6DH65; -.
DR TreeFam; TF105912; -.
DR PRO; PR:Q6DH65; -.
DR Proteomes; UP000000437; Chromosome 10.
DR Bgee; ENSDARG00000037229; -.
DR GO; GO:0070992; C:translation initiation complex; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR GO; GO:0002192; P:IRES-dependent translational initiation of linear mRNA; IBA:GO_Central.
DR GO; GO:0002188; P:translation reinitiation; IBA:GO_Central.
DR Gene3D; 3.30.780.10; -; 1.
DR InterPro; IPR005873; Drp1.
DR InterPro; IPR001950; SUI1.
DR InterPro; IPR005872; SUI1_arc_bac.
DR PANTHER; PTHR12789; PTHR12789; 1.
DR Pfam; PF01253; SUI1; 1.
DR SUPFAM; SSF55159; SSF55159; 2.
DR TIGRFAMs; TIGR01159; DRP1; 1.
DR PROSITE; PS50296; SUI1; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Initiation factor; Phosphoprotein;
KW Protein biosynthesis; Reference proteome.
FT CHAIN 1 208 Density-regulated protein.
FT /FTId=PRO_0000130604.
FT DOMAIN 125 192 SUI1. {ECO:0000255|PROSITE-
FT ProRule:PRU00200}.
FT MOD_RES 9 9 Phosphoserine.
FT {ECO:0000269|PubMed:18307296}.
SQ SEQUENCE 208 AA; 22804 MW; 8AD1E48F5E7F9D53 CRC64;
MATTENAESG SPENKVDRAD PDAKYPLKVL YCGVCSLPAE YCEYMPEPAK CKQWLEKNFP
DVFAKLTLGT APKQESKGGG GGEDGGGGRG RGEAPPAGEE EEKKKQKRGG RGQIKQKKKT
VPQKVTIAKI PRAKKKYVTR VCGLATFDIE LKEAQRFFAQ KFSCGASVTA EDEIIIQGDF
TDDIIDVIQE KWPEVDDDSI DDLGEVKK
//
