ID DHBK_SOLLC Reviewed; 594 AA.
AC O04059;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=Putative 3,4-dihydroxy-2-butanone kinase;
DE EC=2.7.1.-;
GN Name=DHBK;
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. UC82B;
RA Herz S., Eberhardt S., Bacher A.;
RT "L. esculentum mRNA for 3,4 -dihydroxy-2-butanone kinase.";
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dihydroxyacetone kinase (DAK) family.
CC {ECO:0000305}.
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DR EMBL; Y12090; CAA72805.1; -; mRNA.
DR PIR; T06369; T06369.
DR RefSeq; NP_001234326.2; NM_001247397.2.
DR AlphaFoldDB; O04059; -.
DR SMR; O04059; -.
DR STRING; 4081.O04059; -.
DR PaxDb; 4081-Solyc06g072380-2-1; -.
DR GeneID; 544126; -.
DR KEGG; sly:544126; -.
DR eggNOG; KOG2426; Eukaryota.
DR InParanoid; O04059; -.
DR OrthoDB; 6043at2759; -.
DR Proteomes; UP000004994; Unplaced.
DR ExpressionAtlas; O04059; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004371; F:glycerone kinase activity; IBA:GO_Central.
DR GO; GO:0019563; P:glycerol catabolic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.340; -; 1.
DR InterPro; IPR012734; DhaK_ATP.
DR InterPro; IPR004006; DhaK_dom.
DR InterPro; IPR004007; DhaL_dom.
DR InterPro; IPR036117; DhaL_dom_sf.
DR NCBIfam; TIGR02361; dak_ATP; 1.
DR PANTHER; PTHR28629; TRIOKINASE/FMN CYCLASE; 1.
DR PANTHER; PTHR28629:SF4; TRIOKINASE_FMN CYCLASE; 1.
DR Pfam; PF02733; Dak1; 1.
DR Pfam; PF02734; Dak2; 1.
DR SMART; SM01120; Dak2; 1.
DR SUPFAM; SSF82549; DAK1/DegV-like; 1.
DR SUPFAM; SSF101473; DhaL-like; 1.
DR PROSITE; PS51481; DHAK; 1.
DR PROSITE; PS51480; DHAL; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT CHAIN 1..594
FT /note="Putative 3,4-dihydroxy-2-butanone kinase"
FT /id="PRO_0000121531"
FT DOMAIN 11..341
FT /note="DhaK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00814"
FT DOMAIN 381..585
FT /note="DhaL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00813"
FT REGION 339..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 226
FT /note="Tele-hemiaminal-histidine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00814"
FT BINDING 62..65
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 113
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 118
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 410..413
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 455..456
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 499
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 507..508
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 570..572
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 594 AA; 61801 MW; BA19CBEA81BE24AB CRC64;
MDFQSKKLIN DPNDVVTEFI EGLIENYPGL QYLDGFPEVK VVLRADVSGA KYDKVAIISG
GGSGHEPAHA GFVGEGMLTA AICGDVFASP NVDSILAGIR AVTGPMGCLL IVKNYTGDRL
NFGLAAEQAK SEGYKVEMVI VGDDCALPPP RGIAGRRGLA GTLLVHKVAG AAAACGLPLA
DVAAEAKRAS EMVGTMGVAL SVCTSPGQVT SDRLGPGKME LGLGIHGEPG AAVADLQPVD
VVVSHVLKEI LSPETNYVPI TRGSRVVLLI NGLGATPLME LMIIAGKAVP ELQLEHGLAV
DRVYTGSFMT SLDMAGFSIS VMKADQAILD RLDAPTKAPN WPVGAEGNRP PAKIPVPLPP
SHSIKIEKTL SRPEKLSPQG HILETAIEAA ATEVVNLRDN LNEWDNKVGD GDCGSTMFRG
AVAILEDMKK YYPLNDPAET VNEIGASIGR VMGGTSGILY SIFCKAAYAK LKENAESVVT
AIHWADALEA AIAAVSKYGG ASAGYRTLLD ALIPALSALK ERLNAGDDPA DAFIISAEAA
SAGAESTKHM QAQAGRSTYV PGDILASVPD PGAMAAAAWY RAAALAVKEK YNTA
//
