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Database: UniProt
Entry: DNAA1_CHLTR
LinkDB: DNAA1_CHLTR
Original site: DNAA1_CHLTR 
ID   DNAA1_CHLTR             Reviewed;         456 AA.
AC   O84252;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   05-JUL-2017, entry version 102.
DE   RecName: Full=Chromosomal replication initiator protein DnaA 1;
GN   Name=dnaA1; OrderedLocusNames=CT_250;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V.,
RA   Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans:
RT   Chlamydia trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
DR   EMBL; AE001273; AAC67843.1; -; Genomic_DNA.
DR   PIR; D71537; D71537.
DR   RefSeq; NP_219755.1; NC_000117.1.
DR   RefSeq; WP_009871597.1; NC_000117.1.
DR   ProteinModelPortal; O84252; -.
DR   SMR; O84252; -.
DR   EnsemblBacteria; AAC67843; AAC67843; CT_250.
DR   GeneID; 884874; -.
DR   KEGG; ctr:CT_250; -.
DR   PATRIC; fig|272561.5.peg.267; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   InParanoid; O84252; -.
DR   KO; K02313; -.
DR   OMA; DFRYLQG; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    456       Chromosomal replication initiator protein
FT                                DnaA 1.
FT                                /FTId=PRO_0000114162.
FT   NP_BIND     147    154       ATP. {ECO:0000255}.
SQ   SEQUENCE   456 AA;  51996 MW;  50C7E6FD28B47DFC CRC64;
     MRAWEEFLLL QEKEIGVDTV NKWLRSLKVL CFDACNLYLE AKDSFQVTWF EEHIRHKVKA
     SLINNNGKPI RVRVTSLDKS TPFKETQIQQ EKTAYFTMKY GDIDPNMSFA NFLVTPENDL
     PVRILQEFAK VSEQGKGFPF NPIYLFGPES SGKTHLMQAA VGGLREAGVK TLYVTSELFT
     EHLVSAIRSG EMQRFRAFYR NVEALFIEDI EVLSGKGATQ EEFFHTFNSL HTEGKLIVIS
     STFAPGDLKA MEERLISRFE WGISIPVSPL IREGLKSFLE RRTEKLNIRI EETALDFLIQ
     ALSSHVKSLL HALTTLAKRV AYKKLSHQML YQGDIEALLH DVLQAAESIR LTPSGIVRAT
     AQYYGVSPES VLGRSQSREY VLPRQVAMFL CRQKLSLSYV KIGEVFSRDH STVISSIRAI
     SQKLEEDDRE CDVSRAIQEL TKRLSSAYQS LDFIED
//
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