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Database: UniProt
Entry: DNAA2_CHLTR
LinkDB: DNAA2_CHLTR
Original site: DNAA2_CHLTR 
ID   DNAA2_CHLTR             Reviewed;         455 AA.
AC   O84277;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-OCT-2017, entry version 104.
DE   RecName: Full=Chromosomal replication initiator protein DnaA 2;
GN   Name=dnaA2; OrderedLocusNames=CT_275;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V.,
RA   Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans:
RT   Chlamydia trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000305}.
DR   EMBL; AE001273; AAC67868.1; -; Genomic_DNA.
DR   PIR; H71534; H71534.
DR   RefSeq; NP_219780.1; NC_000117.1.
DR   RefSeq; WP_009871622.1; NC_000117.1.
DR   ProteinModelPortal; O84277; -.
DR   SMR; O84277; -.
DR   EnsemblBacteria; AAC67868; AAC67868; CT_275.
DR   GeneID; 884847; -.
DR   KEGG; ctr:CT_275; -.
DR   PATRIC; fig|272561.5.peg.294; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   InParanoid; O84277; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    455       Chromosomal replication initiator protein
FT                                DnaA 2.
FT                                /FTId=PRO_0000114163.
FT   NP_BIND     154    161       ATP. {ECO:0000255}.
SQ   SEQUENCE   455 AA;  51330 MW;  F593F8FBB50A91F1 CRC64;
     MLTCNDCSTW EQFVNYIKTR CSKTAFENWI APIQVLEESS EKIRLEIPNI FVQSYLLDNY
     KKDLCSFVPL DAEGNPALEF VVAEIKRSSP LVTPSIAKPA TEVSEENKDF QLKLNGAYRF
     DNFIEGPSNQ FVKSAALGIA ARPGRSYNPL FIHGGVGLGK THLLHAVGHY VREHHKNLRI
     HCITTEAFIN DLVHHLRVKS IDKMKNFYRS LDLLLVDDIQ FLQNRQNFEE EFCNTFETLI
     HLSKQIVVTS DKPPGQLKLS ERIIARMEWG LVAHVGVPDL ETRVAILQHK AEQKGLNIPN
     EIAFYIADHV YGNVRQLEGA INKLTAYCLL FNKPLTETTV RDTLKELFRA PSKQKVSVES
     ILKSVATVFQ VKIQDLKGSS RAKNVPLARQ VAMYLAKTLI TDSLVAIGAA FGKTHSTVLY
     ACKTIEQKIE KDALLKNQIS LCKNNIAIDS PQHFV
//
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