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Database: UniProt
Entry: DNAA2_PARUW
LinkDB: DNAA2_PARUW
Original site: DNAA2_PARUW 
ID   DNAA2_PARUW             Reviewed;         448 AA.
AC   Q6MEG8;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 2.
DT   25-OCT-2017, entry version 82.
DE   RecName: Full=Chromosomal replication initiator protein DnaA 2 {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA2 {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=pc0307;
OS   Protochlamydia amoebophila (strain UWE25).
OC   Bacteria; Chlamydiae; Parachlamydiales; Parachlamydiaceae;
OC   Candidatus Protochlamydia.
OX   NCBI_TaxID=264201;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UWE25;
RX   PubMed=15073324; DOI=10.1126/science.1096330;
RA   Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U.,
RA   Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D.,
RA   Rattei T., Mewes H.-W., Wagner M.;
RT   "Illuminating the evolutionary history of chlamydiae.";
RL   Science 304:728-730(2004).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; BX908798; CAF23031.1; -; Genomic_DNA.
DR   RefSeq; WP_044044722.1; NC_005861.1.
DR   ProteinModelPortal; Q6MEG8; -.
DR   SMR; Q6MEG8; -.
DR   STRING; 264201.pc0307; -.
DR   EnsemblBacteria; CAF23031; CAF23031; pc0307.
DR   KEGG; pcu:pc0307; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000000529; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    448       Chromosomal replication initiator protein
FT                                DnaA 2.
FT                                /FTId=PRO_0000114227.
FT   NP_BIND     153    160       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   448 AA;  50817 MW;  E5E32F109C20F6A7 CRC64;
     MLTSETQNVW TQFLQFVKTR CSPAAFGNWL APIRVIDCST EEVTLEIPNI FVQEYLLSNY
     KKDLCAFLPV DMSGEPAIRF IIAPPQKKII PPNHFSISSS QKEEQSPNSD VKLNNNYRFE
     NFIEGPTNQF VKSAAMGVAL RPGQSYNPLF IHGGVGLGKT HILHSIGHYI KENHKKLRVQ
     CITTEAFIND LVDSLRNKSV DRMKKFYRSE IDVLLVDDIQ FLQNRLNFEE ELSYTFEALK
     NKGAQIVITS DKPPSLLKLS ERTIGKMEGG LVAHMGIPEL ETRVAILQYK AEQKGLHIPH
     KVAFFIAEHI HNNVRQLEGA INRLSAHCRL LDLNITEELV SRTLREMLQQ APREKISVEQ
     ILKSVAAVFQ VRVSDLRGST RTKDIALPRQ VAMYLAKEMI NESLIMLGAS FGKTHSTILH
     ACKNIEKKVA SDETLRRQIG MVRRNIES
//
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